Covalent binding of glutathione on magnetic nanoparticles: Application for immobilizing small fragment ubiquitin-like-specific protease 1

Kuan, Wei‐Chih; Lai, Jian-Wen; Lee, Wen‐Chien

doi:10.1016/j.enzmictec.2020.109697

Cited by 10 publications

(3 citation statements)

References 32 publications

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“…500,501 Iron oxide nanoparticles are coated with GSH and are also used to promote the stability of immobilized GSH through covalent bonds such as tetraethoxysilane (TEOS). 502 Thus, magnetic nanoparticles attached to GSH can couple enzymes fused to GST through the GSH-GST interaction. In this way, the protease enzyme used with nanoparticles is bound to GSH in identifying the threedimensional structure as they improve the stability and solubility of the protein.…”

Section: Other Enzymesmentioning

confidence: 99%

Advancements in enzyme immobilization on magnetic nanomaterials: toward sustainable industrial applications

Gama Cavalcante,

Dari,

Izaias da Silva Aires

et al. 2024

RSC Adv.

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Section: Other Enzymesmentioning

confidence: 99%

Advancements in enzyme immobilization on magnetic nanomaterials: toward sustainable industrial applications

Gama Cavalcante,

Dari,

Izaias da Silva Aires

et al. 2024

RSC Adv.

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“…It has also been found that the efficacy of GO hybridized with biocompatible polymers may be increased for targeted drug delivery if it is combined with tumor-specific antibodies and drugs [32]. For example, it has been shown that in vivo and in vitro treatment with GO-polyethylene glycol completely destroy prostate cancer tumors in mice with a fewer complications than the drug used alone [33]. It seems that due to the some properties such as drug delivery and absorbing proteins by GO and its derivatieves, the binding and entry of serum hormones and injected hormones into the cells is facilitated, and as a result, the rate of proliferation and maturation of oocytes increases.…”

Section: It Seems That Mgo Induces An Increase In the Expression Of C...mentioning

confidence: 99%

The Effects of Nano Magnetic Graphene Oxide on In Vivo Maturation of Oocyte

Rahimi,

Foroutan,

Eini

2023

Nano Biomedicine and Engineering

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Graphene oxide (GO) and Fe 3 O 4 super paramagnetic material are good candidate for some applications such as drug delivery. It has been shown that combining Fe 3 O 4 with graphene oxide increases the biological efficiency of GO. The use of novel assisted reproductive technologies such as gonadotropins injection has been able to help the fertility of infertile people, but the side effects of these methods and high costs are still problems. The aim of the present study was to investigate the effect of magnetic graphene oxide (MGO) on the in vivo maturation of mouse oocytes. Thirty 6-8week old female Naval Medical Research Institute (NMRI) mice were treated with intra peritoneal (I.P) injection of MGO mixed with hormones. 12 h after I.P. injection of MGO mixed with PMSG and HCG, the number of metaphase II (MII) oocytes obtained from the left fallopian tubes was counted in each group. Also, immuno-cytochemical staining of glutathione and morphometric analysis of ovaries were studied. The results of this study showed that the simultaneous use of MGO, pregnant mare serum gonadotropin (PMSG), and human chorionic gonadotrophin (HCG) increases the number of MII oocytes and helps to increase maturation of oocytes. It could be concluded that MGO can increase the efficiency of super ovulating hormones due to increase in adsorption of serum hormones and growth factors.

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“…(A) GSH was encapsulated into Enteric eudragit L100-cysteine to prepare reduced glutathione nanoparticles (Eul-cys/GSH NPs) [30]; (B) GSH-bound magnetic nanoparticles (SPION@silica-NH 2 ). GSH was reacted with maleic anhydride to form SPION@silica-GSH nanoparticles [31]; (C) transmission electron microscope images of CuO nanoparticles and Au nanoparticles enzyme [32,33].…”

Section: Nano-drug Design Based On the Role Of Gsh In Oxidative Stressmentioning

confidence: 99%

Nano-Drug Design Based on the Physiological Properties of Glutathione

2021

Molecules

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Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.

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Covalent binding of glutathione on magnetic nanoparticles: Application for immobilizing small fragment ubiquitin-like-specific protease 1

Cited by 10 publications

References 32 publications

Advancements in enzyme immobilization on magnetic nanomaterials: toward sustainable industrial applications

Advancements in enzyme immobilization on magnetic nanomaterials: toward sustainable industrial applications

The Effects of Nano Magnetic Graphene Oxide on In Vivo Maturation of Oocyte

Nano-Drug Design Based on the Physiological Properties of Glutathione

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