Covalent attachment of chitosan to graphene <i>via</i> click chemistry for superior antibacterial activity

Huang, Jing; Yin, Zhenyao; Wu, Jinggao

doi:10.1039/d0ma00082e

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…[160] Another type of antibacterial nanocomposite could be obtained by using chitosan equipped with an aryldiazonium group to modify graphene sheets. The resulting assembly showed efficient antimicrobial activity, particularly against S. dysentiriae, [161] opening the door to a host of new possibilities to fight against microbes. Table 1 summarizes the various diazonium salt functionalized nanomaterials described in this review, and their potential applications.…”

Section: Antibacterial Properties Of Nps Functionalized By Diazonium Saltsmentioning

confidence: 99%

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Luo

Onidas

et al. 2021

Advances in Colloid and Interface Science

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Nanoparticles (NPs) can be prepared by simple reactions and methods from a number of materials. Their small size opens up a number of applications in different fields, among which biomedicine, including: i) drug delivery, ii) biosensors, iii) bioimaging, iv) antibacterial activity. To be able to perform such tasks, NPs must be modified with a variety of functional molecules, such as drugs, targeting groups, chemical tags or antibacterial agents, and must also be prevented from aggregation. The attachment must be stable to resist during the transportation to the targeted location. Diazonium salts, which have been widely used for coupling applications and surface modification, fulfil such criteria. Moreover, they are simple to prepare and can be easily substituted with a large number of organic groups. This review describes the use of these compounds in nanomedicine with a focus on the construction of nanohybrids derived from metal, oxide and carbon-based NPs as well as viruses.

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Section: Antibacterial Properties Of Nps Functionalized By Diazonium Saltsmentioning

confidence: 99%

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Luo

Onidas

et al. 2021

Advances in Colloid and Interface Science

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“…An alternative method allowing for the functionalization of graphene with a polysaccharide was recently (2020) described by Huang et al [ 50 ]. In this approach, chitosan ( 1 ) after N-propargylation ( 14 ) was reacted to para -nitrobenzyl azide ( 15 ) by employing CuAAC click chemistry ( Figure 7 ).…”

Section: Covalent Conjugation Of (Poly)saccharides To Graphenementioning

confidence: 99%

“…The reactivity of aryldiazonium salts towards graphene [ 51 , 52 , 53 ] is well-known and it enables the final fixation of the pre-clicked polysaccharide scaffold. In terms of properties, it was found that the graphene-based final material exhibited an improved antimicrobial activity when compared to chitosan itself [ 50 ].…”

Section: Covalent Conjugation Of (Poly)saccharides To Graphenementioning

confidence: 99%

Click Chemistry Enabling Covalent and Non-Covalent Modifications of Graphene with (Poly)saccharides

Papadakis

2020

Polymers

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Graphene is a material with outstanding properties and numerous potential applications in a wide range of research and technology areas, spanning from electronics, energy materials, sensors, and actuators to life-science and many more. However, the insolubility and poor dispersibility of graphene are two major problems hampering its use in certain applications. Tethering mono-, di-, or even poly-saccharides on graphene through click-chemistry is gaining more and more attention as a key modification approach leading to new graphene-based materials (GBM) with improved hydrophilicity and substantial dispersibility in polar solvents, e.g., water. The attachment of (poly)saccharides on graphene further renders the final GBMs biocompatible and could open new routes to novel biomedical and environmental applications. In this review, recent modifications of graphene and other carbon rich materials (CRMs) through click chemistry are reviewed.

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“…Graphene materials are widely regarded as among the most promising options for high-performance devices due to their exceptional electrical conductivity, thermal conductivity, and mechanical stability. − Various GO-based composite films, papers, foams, and sponges have demonstrated excellent performance in the context of wearable pressure sensors. However, limited by GO’s inherent poor dispersion, poor processability, and monofunctionality, endowing GO-based pressure sensors with high sensitivity to small and large deformations to meet the growing demand for high sensitivity versatility and wide range testing requirements remains a great challenge. − Consequently, the chemical modification of graphene to enhance its dispersion, processability, and multifunctionality has emerged as an appealing approach to broaden its practical applicability.…”

Section: Introductionmentioning

confidence: 99%

Facile Graphene Oxide Modification Method via Hydroxyl-yne Click Reaction for Ultrasensitive and Ultrawide Monitoring Pressure Sensors

Hu,

Lu,

Zheng

et al. 2024

ACS Appl. Mater. Interfaces

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Enhancing the durability and functionality of existing materials through sustainable pathways and appropriate structural design represents a time-and costeffective strategy for the development of advanced wearable devices. Herein, a facile graphene oxide (GO) modification method via the hydroxyl-yne click reaction is present for the first time. By the click coupling between propiolate esters and hydroxyl groups on GO under mild conditions, various functional molecules are successfully grafted onto the GO. The modified GO is characterized by FTIR, XRD, TGA, XPS, and contact angle, proving significantly improved dispersibility in various solvents. Besides the high efficiency, high selectivity, and mild reaction conditions, this method is highly practical and accessible, avoiding the need for prefunctionalizations, metals, or toxic reagents. Subsequently, a rGO-PDMS sponge-based piezoresistive sensor developed by modified GO-P2 as the sensitive material exhibits impressive performance: high sensitivity (335 kPa −1 , 0.8−150 kPa), wide linear range (>500 kPa), low detection limit (0.8 kPa), and long-lasting durability (>5000 cycles). Various practical applications have been demonstrated, including body joint movement recognition and real-time monitoring of subtle movements. These results prove the practicality of the methodology and make the rGO-PDMS sponge-based pressure sensor a real candidate for a wide array of wearable applications.

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Covalent attachment of chitosan to graphene via click chemistry for superior antibacterial activity

Abstract: Chemically converted graphene sheets are functionalized by treatment with aryl diazonium salts via click chemistry.

Cited by 8 publications

References 32 publications

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Surface functionalization of nanomaterials by aryl diazonium salts for biomedical sciences

Click Chemistry Enabling Covalent and Non-Covalent Modifications of Graphene with (Poly)saccharides

Facile Graphene Oxide Modification Method via Hydroxyl-yne Click Reaction for Ultrasensitive and Ultrawide Monitoring Pressure Sensors

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