Course features of the chronic gastroduodenitis with underlying food hypersensitivity in adolescents

Bogdanova, T. A.; Березенко, В.С.; Pyankova, O.V.; Gurjeva, O.V.; Golovanenko, G.M.

doi:10.15574/sp.2018.91.54

Cited by 2 publications

(2 citation statements)

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“…The distribution of endoscopic forms such as gastritis and duodenitis was almost uniform and was 94.4 % in group 1 versus 100 % in group 2 in the first case, and 44.4 against 50.0 % with inflammatory changes in the duodenum. It should be noted that among patients with IgE-independent manifestations of food hypersensitivity, in some cases there were erosive (5.5 %) and ulcerative (5.5 %) defects of the gastric and duodenal mucosa, which is comparable to data from other researches [15]. The predominance of destructive changes in the mucous membrane can be explained by the longterm course of gastrointestinal symptoms, which causes the chronicity of the inflammatory process through the links of cell-mediated mechanisms of allergy formation [16].…”

Section: Resultssupporting

confidence: 87%

1

Bubyr¹,

Kryuchko²,

Несіна³

et al. 2021

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Background. In pediatric practice, increasing attention has been recently paid to the study of allergic disorders in various parts of the gastrointestinal tract, and a number of unresolved issues regarding the timely diagnosis and treatment of eosinophilic lesions of the digestive system determines the relevance of this topic. The purpose of the research was to study the endoscopic and morphological changes of the upper gastrointestinal tract in children with gastrointestinal symptoms of food hypersensitivity. Materials and methods. The study enrolled 34 children aged from 6 to 15 years with clinical signs of disorders of the upper digestive tract against the background of food hypersensitivity reactions. Depending on the level of total IgE, study participants were divided into two groups. The first group consisted of 18 children with IgE-independent allergic reactions to food (Me (Q1-Q3) 35.0 (28.0–77.5)). The second group included 16 patients with IgE-induced allergic manifestations of food hypersensitivity (Me (Q1-Q3) 240.5 (158.0–475.8)). To achieve the aim of the research, all children underwent fibroesophagogastroduodenoscopy with subsequent sampling and morphological evaluation of biopsy specimen. Results. According to the results of endoscopic examination of patients, the structure of lesions of the upper gastrointestinal tract depending on the predominance of IgE-independent or IgE-mediated gastrointestinal symptoms of food hypersensitivity did not have statistically significant differences. Morphological characteristics had some differences in the study groups and were represented by the prevalence of eosinophilic infiltration in children with IgE-induced food hypersensitivity reactions. Conclusions. The isolated gastric lesions prevailed in the endoscopic presentation of children with gastrointestinal manifestations of food allergy, and morphological signs of chronic gastritis are characterized by changes in the surface epithelium due to pronounced polymorphonuclear inflammatory infiltration in the lamina propria with a predominance of lymphocytes, neutrophils and plasma cells. The degree of activity of the eosinophilic inflammatory process was more pronounced in the group of children with IgE-induced food hypersensitivity reactions (r = 0.652; p < 0.01).

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Section: Resultssupporting

confidence: 87%

1

Bubyr¹,

Kryuchko²,

Несіна³

et al. 2021

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“…This leads to a variety of clinical symptoms, including gastrointestinal, cutaneous, respiratory, systemic and anaphylaxis [1,2]. Because the gastrointestinal mucosa is in most cases the first to contact with various allergens, the gastrointestinal form ranks second (48-67 %) in the overall structure of clinical symptoms of FA [3][4][5], which therefore explains the interest of scientists to investigate its course and early diagnosis in greater depth. Wide variability of clinical manifestations, concomitant sensitization to household and pollen allergens, lack of unified diagnostic algorithms, difficulties in verification of allergic gastrointestinal lesions in children at primary contact with food allergens, high risk of developing anaphylactic reactions when carrying out oral provocation test as the gold standard of FA diagnosis determine prospects for further research, finding noninvasive diagnostic markers of allergy and creating standardized recommendations [6,7].…”

Section: Introductionmentioning

confidence: 99%

Difficulties in diagnosing gastrointestinal allergy in paediatric practice: a clinical case

Kryuchko

Bubyr

Пода

et al. 2023

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Since allergy pathology in the structure of general somatic diseases occupies a significant niche in both adult and child populations and is accompanied by a number of unresolved issues, it represents a major medical and social problem. The use of modern diagnostic techniques has made it possible to broaden scientists’ knowledge of the in-depth mechanisms of the pathogenesis of allergic diseases with the subsequent development and implementation of new diagnostic, therapeutic and prophylactic recommendations. However, the multidisciplinary aspects of paediatric allergy continue to be studied; among them, the problems of specific diagnosis of food allergy are of particular importance. Recently, the study of allergic lesions in the various parts of the gastrointestinal tract has received increasing attention in paediatric practice. Since in most cases the mucosa of the digestive system is the first to contact with allergens of various nature, the gastrointestinal form ranks second in the overall structure of clinical symptoms of food allergy. Gastrointestinal symptoms of food allergy are characterized by polymorphic manifestations, making timely verification of the diagnosis difficult. This leads to prolonged differential analysis and requires the exclusion of concomitant organic and functional gastrointestinal pathology, which delays early diagnosis and timely therapeutic recommendations for patients with food allergy. The relevance of the above-mentioned problem is highlighted by the following clinical case.

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Course features of the chronic gastroduodenitis with underlying food hypersensitivity in adolescents

Cited by 2 publications

References 2 publications

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Difficulties in diagnosing gastrointestinal allergy in paediatric practice: a clinical case

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