Course and Prognosis of Prostatectomy

Plorde, James J.; Kennedy, Roger P.; Bourne, Hal H.; Ansell, Julian S.; Petersdorf, Robert G.

doi:10.1056/nejm196502112720601

Cited by 71 publications

(1 citation statement)

References 9 publications

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“…3 Secondly, many fevers occur when no bacteremia can be detected, despite intense culturing. 34 - 7 Thirdly, appropriate antimicrobials have failed to ameliorate febrile morbidity in many studies. 8 1 1 These observations have caused other investigators to speculate that the majority of the fevers remain unexplained, and are more likely due to nonseptic factors, such as the absorption of tissue proteins.…”

Section: Discussionmentioning

confidence: 99%

Endotoxin Contamination of Foley Catheters Associated With Fevers Following Transurethral Resection of the Prostate

Gephart

1984

Infect. Control

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In 1980 an investigation was conducted due to an apparent cluster of fevers following transurethral resections of the prostate (TURP), where the presence of prostatitis or urinary tract infections (UTIs) could not account for most cases, and the usage of antimicrobials did not prevent them. When unused, prepackaged, sterilized samples from 13 lots of triple lumen catheters were analyzed, four were found to contain high levels of endotoxin (ET), with a range of 49,150-≥ 6.25 ng/catheter. Additionally, these lots were highly pyrogenic to rabbits. The maximum incidence of febrile patients (42%) correlated with usage of catheters from the lot where ET levels were the highest. The febrile rate for a second urologist, who used single lumen catheters, was less (12/33 v 0/12). Further consideration should be given to sterile operative equipment which may still be pyrogenic.

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Section: Discussionmentioning

confidence: 99%