Course and Prognosis in Rheumatoid Arthritis

Duthie, J. J. R.; Brown, Patricia E.; Knox, J. D. E.; Thompson, M.

doi:10.1136/ard.16.4.411

Cited by 106 publications

(32 citation statements)

References 4 publications

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“…The composition of the group is shown in Table I. The progress of this group since discharge from the hospital has already been reported in detail by Duthie, Brown, Knox, and Thompson (1957). Haemoglobin levels were measured colorimetrically by the alkali-haematin method of Clegg and King (1942), with 100% haemoglobin equal to 14.8 g./100 ml.…”

Section: Methodsmentioning

confidence: 99%

Importance of Aspirin as a Cause of Anaemia and Peptic Ulcer in Rheumatoid Arthritis

Baragar¹,

Duthie²

1960

BMJ

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Section: Methodsmentioning

confidence: 99%

Importance of Aspirin as a Cause of Anaemia and Peptic Ulcer in Rheumatoid Arthritis

Baragar¹,

Duthie²

1960

BMJ

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“…Such IgM RF has been found in the serum up to four years before the start of the disease [49]. Seropositive rheumatoid arthritis is generally a more severe disease than seronegative rheumatoid arthritis [50]. An association between seropositivity and certain HLA types has also been demon-strated [51].…”

Section: Possible Pathogenic Role Q[' Rf-immune Complex Jormation In mentioning

confidence: 97%

Possible role of microbial IgG Fc-binding proteins in rheumatoid arthritis

Christensen

Schröder

1990

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IgG Fc binding substances (receptors) are widespread among pathogenic microorganisms. The receptors from Staphylococcus aureus, streptococci of group A, C and G as well as Herpes-infected cells bind to the interface between the CH2 and CH3 domains i.e. to His 435, Tyr 436 and possibly also His 433 and/or 310. Most rheumatoid factors (RF) from patients with rheumatoid arthritis show a similar binding pattern. Hence, it has been shown that antibodies to microbial IgG Fc receptors (S. aureus and group A streptococci type M15) and RF are idiotypic-anti-idiotypic antibody "partners" i.e. that RF are the "internal images" of microbial IgG Fc binding proteins. Group A streptococci possessing IgG Fc receptors elicit higher titres of RF when injected in rabbits as compared to group A streptococci without IgG Fc receptors. The streptococcal IgG Fc receptors exhibit a diversity of preferences for subclasses of human IgG, some of them showing allotype preferences. Such allotypes are also recognized by certain RF. IgG RF are able to self-associate thereby forming immune complexes which can activate the complement cascade as well as stimulate release of prostaglandins and (probably) interleukin-1. Since these factors have been assigned an important pathogenic role in rheumatoid arthritis, self-aggregating IgG RF, proposed to be induced by microbial IgG Fc receptors might be an important pathogenic factor in rheumatoid arthritis because rheumatoid arthritis is the only known condition where synthesis of RF takes place in the synovia.

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“…An alternative explanation may be that cases with and without rheumatoid fector represent two different disease groups. As Dixon (1960) has pointed out, sero-negative rheumatoid arthritis is a somewhat heterogeneous entity, and Duthie, Brown, Knox, and Thompson (1957) have shown that the prognosis in this group is better than in the sero-positive cases. Every effort was made to ensure accurate diagnosis, but it is possible that the sero-negative cases include a few examples of such 27 ANNALS OF THE RHEUMATIC DISEASES conditions as psoriatic arthropathy without skin lesions (Baker, Golding, and Thompson, 1963) and Reiter's syndrome, in which the urethritis has been long forgotten or not admitted.…”

Section: Electrophoresis Of Syno Vial Fluid Proteins Synovial Biopsiementioning

confidence: 98%