Course and Causes of Suspected Dementia in Young Adults: A Longitudinal Study

Panegyres, Peter K.; Frencham, Kate

doi:10.1177/1533317506295887

Cited by 61 publications

(89 citation statements)

References 33 publications

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“…Only 3 patients (1.4%) had AD. The high frequency of behavioral and psychiatric symptoms early in the course of disease is quite distinct from the clinical features of later-onset dementia and echoes the findings in young-onset CJD [3,4] and in well-characterized EOD cohorts [8,14,21] .…”

Section: Associated Seizure Disordersupporting

confidence: 65%

Cognitive and Noncognitive Neurological Features of Young-Onset Dementia

Kelley

Boeve

Josephs

2009

Dement Geriatr Cogn Disord

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Background: The rarity of young-onset dementia (YOD), the broad differential diagnosis and unusual clinical presentations present unique challenges to correctly recognize the condition and establish an accurate diagnosis. Limited data exist regarding clinical features associated with dementia prior to the age of 45. Methods: We retrospectively assessed cognitive and noncognitive neurological characteristics of 235 patients who presented for evaluation of YOD to investigate the clinical characteristics of YOD compared to later-onset dementias and to identify clinical features associated with specific etiologies that may aid in the evaluation of YOD. Results: Multiple cognitive domains were affected in most patients, and no significant differences in affected domains existed between groups. Early psychiatric and behavioral features occurred at very high frequencies. Nearly 80% of this YOD cohort had additional noncognitive symptoms or signs as a feature of their disease. Chorea was strongly associated with Huntington disease. Parkinsonism was not seen in patients having an autoimmune/inflammatory etiology. Conclusions: The rarity of YOD and the high frequency of early psychiatric features led to frequent misdiagnosis early in the clinical course. The high frequency of noncognitive symptoms and signs may aid clinicians in distinguishing patients requiring a more extensive evaluation for YOD.

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Section: Associated Seizure Disordersupporting

confidence: 65%

Cognitive and Noncognitive Neurological Features of Young-Onset Dementia

Kelley

Boeve

Josephs

2009

Dement Geriatr Cogn Disord

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“…This complicates the challenge in obtaining a diagnosis, adding to the stress already heaped upon the individuals and family unit. Moreover, whilst the syndrome of dementia in younger people is diverse (Harvey, Skelton-Robinson & Rossor, 2003;Panegyres & Frencham, 2007), an additional pressure involved in this cohort, particularly for younger-onset Alzheimer's disease (Newens et al, 1993), is the rapid progress through the stages of the condition (Cox & Keady, 1999). Even upon receipt of the diagnosis of dementia, for younger people, the diagnostic label does little to instill the possibility of a sense of hope and continuity in everyday roles.…”

Section: Discussionmentioning

confidence: 99%

Selfhood in younger onset dementia: Transitions and testimonies

Harris

Keady

2009

Aging & Mental Health

153

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Younger people with dementia and their carers are an overlooked population for research, policy and practice attention. In this study, data were collected from both the United States and the UK in order to explore the meaning and construction of selfhood and identity. The US data collection included in-depth interviews with 23 people diagnosed with younger-onset dementia, while the UK data collection comprised 15 face-to-face interviews with younger carers of younger people with dementia; all carers were/had been caring for a younger person with dementia diagnosed through the DSM-IV-R criteria. A grounded theory analysis of the data resulted in the emergence of five themes to explain the interview data, these were: (1) identity as a worker; (2) identity of abandoned individual; (3) sexual identity; (4) family identity; and (5) identity as an individual engaged in living. Additional research is necessary to further develop the attributes and application of these identity profiles.

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“…A change of personality and behaviour are also commonly associated with alcohol-related brain damage (Moriyama et al 2006). As the wider literature reveals, alcohol-related brain damage undermines a person's ability to lead an independent life (Ganguli et al 2005, Moriyama et al 2006, Panegyres and Frencham 2007 and may be common in people who are homeless (Gilchrist and Morrison 2005).…”

Section: Alcohol-related Brain Damage: Context and Consequencesmentioning

confidence: 99%

Alcohol-related brain damage: Narrative storylines and risk constructions

Keady

Clarke

Wilkinson

et al. 2009

Health, Risk & Society

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To date, the voice and experience of people with alcohol-related brain damage has been silent in the literature. Using narrative research methodology and a focus on risk and quality of life, this paper outlines the analysis of interviews with six people with alcohol-related brain damage who were resident on a specialist care unit for the condition. Of the six participants, four were interviewed twice in line with the study protocol and separate interviews were conducted with a key worker on the unit, a social worker and a relative of one of the female participants. Analysis of the interviews revealed three dominant, narrative storylines: Five Minute Memory; Fractured Lives; and Believing in Recovery. Risk was constructed and experienced in a variety of ways under each of these narrative storylines, but each participant was particularly vulnerable to the assimilation of alcohol-related brain damage as a component and projection of self and identity. In addition, the process of 'prompting' emerged as a way that care staff constructed and discharged their rehabilitative function on the care unit and worked to minimise risk factors. A more co-ordinated, robust and transparent funding, policy, education and service structure for people with alcohol-related brain damage is called for.

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Course and Causes of Suspected Dementia in Young Adults: A Longitudinal Study

Cited by 61 publications

References 33 publications

Cognitive and Noncognitive Neurological Features of Young-Onset Dementia

Cognitive and Noncognitive Neurological Features of Young-Onset Dementia

Selfhood in younger onset dementia: Transitions and testimonies

Alcohol-related brain damage: Narrative storylines and risk constructions

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