Courbes de croissance in utero ajustées et non ajustées adaptées à la population française. II – Comparaison à des courbes existantes et apport de l’ajustement

Ego, Anne; Prunet, C.; Blondel, Béatrice; Kaminski, Monique; Goffinet, François; Zeitlin, Jennifer

doi:10.1016/j.jgyn.2015.08.008

Cited by 34 publications

(4 citation statements)

References 30 publications

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“…Using population-based data from a large prospective cohort of children born with isolated CHD, we found that the overall prevalence of SGA was 13% and that of severe SGA 5%, both of which are higher than the expected proportions in the general population, 10 and 3%, respectively, based on the EPOPé population-based growth curves in France (7,11). We also found important differences in the probability of SGA and of severe SGA across the different types of CHD.…”

Section: Discussionmentioning

confidence: 76%

Prevalence of Growth Restriction at Birth for Newborns With Congenital Heart Defects: A Population-Based Prospective Cohort Study EPICARD

et al. 2021

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Background and Objectives: Congenital heart defects (CHD) and growth restriction at birth are two major causes of childhood and adult morbidity and mortality. The aim of this study was to assess the overall risk of growth restriction at birth, as measured by its imperfect proxy small (< 10th percentile) for gestational age (SGA), for newborns with CHD.Methods: Using data from a population-based cohort of children born with CHD, we assessed the risk of growth restriction at birth using SGA and severe SGA (3rd percentile). To compare the odds of SGA and severe SGA across five specific major CHD, we used ordinal logistic regression using isolated, minor (non-operated) ventricular septal defect (VSD) as the control group.Results: The overall proportion of SGA for “isolated” CHD (i.e., those not associated with other anomalies) was 13% (95% CI, 12–15%), which is 30% higher than what would be expected in the general population (i.e., 10%). The risk of severe SGA was 5% (95% CI, 4–6%) as compared with the expected 3% in the general population. There were substantial differences in the risk of overall SGA and more so severe SGA across the different CHD. The highest risk of SGA occurred for Tetralogy of Fallot (adjusted OR 2.7, 95% CI, 1.3–5.8) and operated VSD (adjusted OR 2.1, 95% CI, 1.1–3.8) as compared with the control group of minor (non-operated) VSD.Conclusion: The overall risks of both SGA and severe SGA were higher in isolated CHD than what would be expected in the general population with substantial differences across the subtypes of CHD. These results may provide a clue for understanding the underlying mechanisms of the relation between alterations in fetal circulation associated with different types of CHD and their effects on fetal growth.

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Section: Discussionmentioning

confidence: 76%

Prevalence of Growth Restriction at Birth for Newborns With Congenital Heart Defects: A Population-Based Prospective Cohort Study EPICARD

et al. 2021

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“…Preterm birth (yes/no) was defined as babies born before 37 weeks of gestation. Birth weight customized z -scores were calculated according to Gardosi references taking into account physiological fetal (sex and gestational age) and maternal factors (weight, height, parity, origin) [ 27 ]. Newborns were classified, according to this customized approach, into three classes: small for gestational age (SGA, ≤10th percentile), appropriate for gestational age (AGA, >10th percentile to ≤90 th percentile), and LGA (>90 th percentile).…”

Section: Methodsmentioning

confidence: 99%

Association between perinatal factors, genetic susceptibility to obesity and age at adiposity rebound in children of the EDEN mother–child cohort

et al. 2021

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Background Early adiposity rebound (AR) has been associated with increased risk of overweight or obesity in adulthood. However, little is known about early predictors of age at AR. We aimed to study the role of perinatal factors and genetic susceptibility to obesity in the kinetics of AR. Methods Body mass index (BMI) curves were modelled by using mixed-effects cubic models, and age at AR was estimated for 1415 children of the EDEN mother–child cohort study. A combined obesity risk-allele score was calculated from genotypes for 27 variants identified by genome-wide association studies of adult BMI. Perinatal factors of interest were maternal age at delivery, parental education, parental BMI, gestational weight gain, maternal smoking during pregnancy, and newborn characteristics (sex, prematurity, and birth weight). We used a hierarchical level approach with multivariable linear regression model to investigate the association between these factors, obesity risk-allele score, and age at AR. Results A higher genetic susceptibility to obesity score was associated with an earlier age at AR. At the most distal level of the hierarchical model, maternal and paternal educational levels were positively associated with age at AR. Children born to parents with higher BMI were more likely to exhibit earlier age at AR. In addition, higher gestational weight gain was related to earlier age at AR. For children born small for gestational age, the average age at AR was 88 [±39] days lower than for children born appropriate for gestational age and 91 [±56] days lower than for children born large for gestational age. Conclusion The timing of AR seems to be an early childhood manifestation of the genetic susceptibility to adult obesity. We further identified low birth weight and gestational weight gain as novel predictors of early AR, highlighting the role of the intrauterine environment in the kinetics of adiposity.

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“…Birth weight, birth length, head circumference, and gestational age at birth were treated as continuous variables. Sex and gestational age-specific z scores customized for maternal weight, height, and parity were computed using a method adapted for the French 2010 national perinatal survey, from that proposed by Gardosi 27 . Percentiles were then derived and used to define fetal growth categories: small for gestational age (SGA, <10 th percentile), appropriate for gestational age (AGA, 10 th to 90 th percentile), and large for gestational age (LGA, >90 th percentile).…”

Section: Pregnancy and Fetal Outcomesmentioning

confidence: 99%

Pregnancy outcomes in women with preexisting thyroid diseases: a French cohort study

Lecorguillé

Léger

Forhan

et al. 2020

J Dev Orig Health Dis

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Women with thyroid diseases at the beginning of pregnancy may have suboptimal thyroid hormone levels because of potential difficulties in compensating for the physiological thyroid hormone changes occurring in pregnancy. Our objective was to study the association between preexisting thyroid diseases, pregnancy complications, and neonatal anthropometry. In total, 16,395 women from the ELFE French longitudinal birth cohort were included, and 273 declared pre-pregnancy thyroid diseases. Associations were investigated with multivariable regression models, with adjustment for relevant potential confounders. Body mass index (BMI) was additionally adjusted for in a second stage. As compared with other women, women with pre-pregnancy thyroid diseases were more frequently obese (19.6% vs. 9.8%) and had greater odds of gestational diabetes development (odds ratio [OR] = 1.58 [95% confidence interval [CI] 1.08, 2.30]) or had undergone treatment for infertility (OR = 1.57 [95% CI 1.07, 2.31]). After adjustment for BMI, the association with gestational diabetes was no longer significant (OR = 1.27 [95% CI 0.86, 1.88]). After excluding women with another medical history, those with pre-pregnancy thyroid diseases had increased odds of premature rupture of membranes (OR = 1.51 [95% CI 1.01, 2.25]). Children born from mothers with hypothyroidism before conception due to a disease or as a potential side effect of treatment had a smaller head circumference at birth than other children (β = −0.23 [95% CI −0.44, −0.01] cm). In conclusion, pre-pregnancy thyroid diseases were associated with risk of infertility treatment, gestational diabetes, and premature rupture of membranes. The association between history of hypothyroidism and moderate adverse effects on fetal head circumference growth needs replication.

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Courbes de croissance in utero ajustées et non ajustées adaptées à la population française. II – Comparaison à des courbes existantes et apport de l’ajustement

Cited by 34 publications

References 30 publications

Prevalence of Growth Restriction at Birth for Newborns With Congenital Heart Defects: A Population-Based Prospective Cohort Study EPICARD

Prevalence of Growth Restriction at Birth for Newborns With Congenital Heart Defects: A Population-Based Prospective Cohort Study EPICARD

Association between perinatal factors, genetic susceptibility to obesity and age at adiposity rebound in children of the EDEN mother–child cohort

Pregnancy outcomes in women with preexisting thyroid diseases: a French cohort study

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