Coupling Ultrasound with Heat-Reflux to Improve the Extraction of Quercetin, Kaempferol, Ginkgetin and Sciadopitysin from Mairei Yew Leaves

Zhao, Chunjian; Ren, Xueting; Li, Chunying; Jiang, Hongwei; Guan, Jiajing; Su, Weiran; Li, Yuzheng; Tian, Ye; Wang, Tingting; Shen, Li

doi:10.3390/app9040795

Cited by 7 publications

(4 citation statements)

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“…The HRE method is a method of extracting raw material components using volatile organic solvents such as ethanol, heating, and distilling the leaching solution [38]. The advantage of HRE is high efficiency: the reflux extraction method has a low amount of reference solvent, is relatively simple to operate, and has high efficiency [39]. The disadvantage of HRE is high solvent consumption: the reflux extraction method has a longer heating time and is prone to damage thermally unstable components, resulting in high solvent consumption [40].…”

Section: Current State Of the Extraction Technology For Flavonoidsmentioning

confidence: 99%

Application of deep eutectic solvents on extraction of flavonoids

Hao,

Pei,

Huang

et al. 2024

J of Separation Science

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Deep eutectic solvents (DESs), as a new type of eco‐friendly solvent, have attracted increasing attention on the extraction and separation of flavonoid compounds from various samples, owing to their excellent properties such as biodegradability and ease of handling with very low toxicity. This article provides a status review of the applications of DESs in the extraction of flavonoids, including the introduction of flavonoid compounds, the properties and superiority of DESs, and extraction methods (ultrasonic‐assisted extraction, heating reflux extraction, matrix solid‐phase dispersion, and solid‐phase extraction). Finally, prospects and challenges in the application of DESs on extraction and separation are extensively elucidated and critically reviewed.

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Section: Current State Of the Extraction Technology For Flavonoidsmentioning

confidence: 99%

Application of deep eutectic solvents on extraction of flavonoids

Hao,

Pei,

Huang

et al. 2024

J of Separation Science

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“…Đồng thời, kĩ thuật chiết nóng có nhược điểm là hiệu suất thấp và thời gian kéo dài. Hiện nay, chiết xuất hỗ trợ siêu âm là phương pháp góp phần khắc phục những hạn chế của phương pháp chiết nóng truyền thống [3,4].…”

Section: ________unclassified

“…-Thiết lập điều kiện chiết [2,3,6]: Dung môi methanol/H2O (tỉ lệ thể tích 50:20); dung môi bổ sung axit (methanol/H2O/HCl, 50:20:8); tỉ lệ bột nguyên liệu và dung môi là 1:50, g/ml; điều kiện chiết không siêu âm (KSA) ở 90 o C; chiết siêu âm (SA) ở 70 o C trong bể có tần số 37Hz. Thời gian khảo sát, lựa chọn 15, 30, 60, 90 và 120 phút.…”

Section: Chiết Xuất Quercetin Từ Thực Vậtunclassified

“…Tuy nhiên sự ổn định của quercetin trong các hệ dung môi này chưa được đánh giá. Nghiên cứu của chúng tôi phát triển điều kiện chiết xuất của Nishimuro kết hợp với Zhao và cộng sự, để thiết lập và đánh giá sự ổn định của quercetin theo hệ methanol/H2O (50:20) hoặc methanol/H2O/HCl (tỉ lệ 50:20:8), chiết trong điều kiện không siêu âm (KSA) hoặc siêu âm (SA) [2,3].…”

Section: Thiết Lập đIều Kiện Thủy Phân Có Hỗ Trợ Siêu âM để Thu Nhận unclassified

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Study of Ultrasound-assisted Acid Hydrolysis to Obtain Quercetin and their Antioxidant Activities from some Plants

Hoang¹,

Phuong²,

Hanh³

et al. 2019

NST

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In this study, acidic hydrolysis to release the aglycone quercetin from plant extracts under ultrasound-assisted conditions was investigated. Based on the stability of quercetin, the suitable conditions were as follows: methanol/H2O (50:20, v/v) was added to the powder plants (ratio 50:1, ml/g), these mixtures were placed in ultrasonic bath of 37 kHz/550W; kept at 70°C within 30 min and then filtered. The filtrate was acidified with HCl (70:8, ml/ml). Lastly, the ultrasonication was carried out for hydrolysis for 1 hour (the second ultrasound) to obtain quercetin. We have obtained quercetin containing hydrolyzed extract from 10 plants to determine quercetin concentrations (using the HPLC optimized conditions) and evaluate the antioxidant activity (the capability to scavenge the DPPH radical). In 10 samples of plants that were obtained, both quercetin concentrations and antioxidant activity in the plant extract of the flower buds of Sophora japonica L have the highest value, then to the plant extract of Nelumbo nucifera Gaertn. In the Sophora flower-bud and the lotus leaf, quercetin content is calculated on dry material (mg/100g), 15423.04 and 5190.82 respectively; the average percentage inhibition of DPPH 100 µM (%) 55.26% and 32.23%., respectively. Keywords: Quercetin, HPLC, acid hydrolysis, ultrasound-assisted, antioxidant activity. References [1] S.G. Dmitrienko, V.A. Kudrinskaya, V.V. Apyari, Methods of extraction, preconcentration, and determination of quercetin, Journal of Analytical Chemistry 67 (4) (2012) 299-311. https://doi.org/ 101134/S106193481204003X.[2] H. Nishimuro, H. Ohnishi, M. Sato, M. Ohnishi-Kameyama, I. Matsunaga, S. Naito, K. Ippoushi, H. Oike, T. Nagata, H. Akasaka, S. Saitoh, K. Shimamoto, M. Konori, Estimated daily intake and seasonal food sources of quercetin in Japan, Nutrients 7 (4) (2015) 2345-2355. https://doi.org/ 10.3390/nu7042345.[3] C. Zhao, X. Ren, C. Li, H. Jiang, J. Guan, W. Su, Y. Li, Y. Tian, T. Wang, S. Li, Coupling ultrasound with heat-reflux to improve the extraction of quercetin, kaempferol, ginkgetin and sciadopitysin from Mairei Yew leaves, Applied Sciences 9 (4) (2019) 795-810. https://doi.org/10.3390/app9040795.[4] J. Azmir, M.S.I. Zaidul, M.M. Rahman, K.M. Sharif, A. Mohamed., F. Sahena, A.H.M. Jahurul, K. Ghafoor, N.A.N. Norulain, K.A.M. Omar, Techniques for extraction of bioactive compounds from plant materials : A review, Journal of Food Engineering 117 (4) (2013) 426-434. https://doi. org/10.1016/j.jfoodeng.2013.01.014.[5] L.H. Hoang, D.T.H. Anh, D.T. Hue, T.T.K. Oanh, N.Q. Huy, Determination of Quercetin Aglycone in Flos Sophorae japonicae Extract by High Performance Liquid Chromatography, VNU Journal of Science: Natural Sciences and Technology 33 (1S) (2017) 214-223 (in Vietnamese). https://doi.org/10.25073/2588-1140/ vnunst.4534. [6] A.M. Nuutila, K. Kammiovirta, M. Oksman-Caldentay, Comparison of methods for the hydrolysis of flavonoids and phenolic acids from onion and spinach for HPLC analysis, Food Chemistry 76 (4) (2002) 519-525. https://doi.org/ 10.1016/S0308-8146(01)00305-3.[7] L. Qiao, Y. Sun, R. Chen, Y. Fu, W. Zhang, X. Li, J. Chen, Y. Shen, X. Ye, Sonochemical effects on 14 flavonoids common in citrus : Relation to stability, Plos One 9 (2) (2014) e87766. https://doi. org/10.1371/journal.pone.0087766.[8] W. Brand-Williams, M.E. Cuvelier, C. Berset, Use of a free radical method to evaluate antioxidant activity, LWT - Food Science and Technology 28 (1995) 25-30. https://doi.org/10.1016/S0023-6438 (95)80008-5. [9] M. Biesaga, Influence of extraction methods on stability of flavonoids, Journal of Chromatography A 1218 (2011) 2505-2512. https://doi.org/10.1016/ j.chroma.2011.02.059.[10] L. Paniwnyk, E. Beaufoy, J.P. Lorimer, T.J. Manson, The extraction of rutin from flower buds of Sophora japonica, Ultrasonics Sonochemistry 8 (3) (2001) 299-301. https://doi.org/10.1016/S1350 -4177(00)00075-4.[11] X. He, Y. Bai, Z. Zhao, X. Wang, J. Fang, L. Huang, M. Zeng, Q. Zhang, Y. Zhang, Z. Zheng, Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L.: A review, Journal of Ethnopharmacology 187 (2016) 160-182. https://doi.org/10.1016/j.jep.2016.04.014.[12] I.Y. Bae, B.Y. Kwak, H.G. Lee, Synergistic antiradical action of natural antioxidants and herbal mixture for preventing dioxin toxicity, Food Science and Biotechnology 21 (2) (2012) 491-496. https://doi.org/10.1007/s10068-012-0062-9.

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