Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans

Niknazar, Mohammad; Krishnan, Giri P.; Bazhenov, Maxim; Mednick, Sara C.

doi:10.1371/journal.pone.0144720

Cited by 132 publications

(147 citation statements)

References 35 publications

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“…Recent work has begun to integrate formerly independent lines of research on sleep SO and spindle activity, suggesting that their interplay might be critical for sleep‐related memory consolidation (Helfrich et al., ; Molle & Born, ; Niknazar, Krishnan, Bazhenov, & Mednick, ). Our work supports this notion by replicating the distinct temporal interaction of SO and spindle activity in the cortical up‐state and its correlation with declarative memory consolidation in young adults.…”

Section: Discussionmentioning

confidence: 99%

Phase‐amplitude coupling of sleep slow oscillatory and spindle activity correlates with overnight memory consolidation

Mikutta

Feige

Maier

et al. 2019

Journal of Sleep Research

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Initially independent lines of research suggest that sleep‐specific brain activity patterns, observed as electroencephalographic slow oscillatory and sleep spindle activity, promote memory consolidation and underlying synaptic refinements. Here, we further tested the emerging concept that specifically the coordinated interplay of slow oscillations and spindle activity (phase‐amplitude coupling) support memory consolidation. Particularly, we associated indices of the interplay between slow oscillatory (0.16–1.25 Hz) and spindle activity (12–16 Hz) during non‐rapid eye movement sleep (strength [modulation index] and phase degree of coupling) in 20 healthy adults with parameters of overnight declarative (word‐list task) and procedural (mirror‐tracing task) memory consolidation. The pattern of results supports the notion that the interplay between oscillations facilitates memory consolidation. The coincidence of the spindle amplitude maximum with the up‐state of the slow oscillation (phase degree) was significantly associated with declarative memory consolidation (r = .65, p = .013), whereas the overall strength of coupling (modulation index) correlated with procedural memory consolidation (r = .45, p = .04). Future studies are needed to test for potential causal effects of the observed association between neural oscillations during sleep and memory consolidation, and to elucidate ways of modulating these processes, for instance through non‐invasive brain‐stimulation techniques.

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Section: Discussionmentioning

confidence: 99%

Phase‐amplitude coupling of sleep slow oscillatory and spindle activity correlates with overnight memory consolidation

Mikutta

Feige

Maier

et al. 2019

Journal of Sleep Research

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“…While we found network states dominated by either spindles or slow oscillations, under certain conditions (such as only moderate reduction of the ACh level) we also observed mixed states combining these two major rhythms. Such mixed states may occur in vivo under normal conditions (Aeschbach and Borbely, 1993; Muller et al, 2006); our recent behavior study suggests that the strengths of the phase amplitude coupling between the spindle and the slow oscillation during NREM sleep correlates with memory consolidation (Niknazar et al, 2015). We speculate that the mixed states may become prevalent in some pathological conditions such as in Alzheimer’s disease where sleep is altered and changes to the neuromodulatory system are reported (Wulff et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Cellular and neurochemical basis of sleep stages in the thalamocortical network

Krishnan

Chauvette

Shamie

et al. 2016

eLife

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130

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The link between the combined action of neuromodulators in the brain and global brain states remains a mystery. In this study, using biophysically realistic models of the thalamocortical network, we identified the critical intrinsic and synaptic mechanisms, associated with the putative action of acetylcholine (ACh), GABA and monoamines, which lead to transitions between primary brain vigilance states (waking, non-rapid eye movement sleep [NREM] and REM sleep) within an ultradian cycle. Using ECoG recordings from humans and LFP recordings from cats and mice, we found that during NREM sleep the power of spindle and delta oscillations is negatively correlated in humans and positively correlated in animal recordings. We explained this discrepancy by the differences in the relative level of ACh. Overall, our study revealed the critical intrinsic and synaptic mechanisms through which different neuromodulators acting in combination result in characteristic brain EEG rhythms and transitions between sleep stages.DOI: http://dx.doi.org/10.7554/eLife.18607.001

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“…We focused on Stage 2 sleep because sleep spindles are most prominent during this stage, also, prior studies have shown that sleep coordination between spindles and SOs during Stage 2 (as compared to slow wave sleep) may have a specific memory benefit (Niknazar et al, 2015).…”

Section: Electrophysiological Datamentioning

confidence: 99%

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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Memory formation can be influenced by sleep and sex hormones in both men and women, and by the menstrual cycle in women. Though many studies have shown that sleep benefits the consolidation of memories, it is not clear whether this effect differs between men and women in general or according to menstrual phase in women. The present study investigated the effect of sex and menstrual cycle on memory consolidation of face-name associations (FNA) following a daytime nap. Recognition memory was tested using a face-name paired associates task with a polysomnographic nap between morning and evening testing. Seventeen healthy women (age: 20.75 (1.98) years) were studied at two time points of their menstrual cycles, defined from self-report and separated by 2 weeks (perimenses: -5 days to + 6 days from the start of menses, and non-perimenses: outside of the perimenses phase) and compared with eighteen healthy men (age: 22.01 (2.91) years). Regardless of menstrual phase, women had better pre-nap performance than men. Further, menstrual phase affected post-nap memory consolidation, with women showing greater forgetting in their perimenses phase compared with their nonperimenses phase, and men. Interestingly, post-nap performance correlated with electrophysiological events during sleep (slow oscillations, spindles, and temporal coupling between the two), however, these correlations differed according to menstrual phase and sex.Men's performance improvement was associated with the temporal coupling of spindles and slow oscillations (i.e., spindle/SO coincidence) as well as spindles. Women, however, showed an association with slow oscillations during non-perimenses, whereas when they were in their perimenses phase of their cycle, women appeared to show an association only with sleep spindle events for consolidation. These findings add to the growing literature demonstrating sex and menstrual phase effects on memory formation during sleep. THE EFFECT OF SEX AND MENSTRUAL CYCLE ON MEMORY 3

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Coupling of Thalamocortical Sleep Oscillations Are Important for Memory Consolidation in Humans

Cited by 132 publications

References 35 publications

Phase‐amplitude coupling of sleep slow oscillatory and spindle activity correlates with overnight memory consolidation

Phase‐amplitude coupling of sleep slow oscillatory and spindle activity correlates with overnight memory consolidation

Cellular and neurochemical basis of sleep stages in the thalamocortical network

The effect of sex and menstrual phase on memory formation during a nap

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