Coupling of capillary gas chromatograph and Fourier transform mass spectrometer

Ledford, Edward B.; White, Robert L.; Ghaderi, Sahba.; Wilkins, Charles L.; Gross, Michael L.

doi:10.1021/ac50064a056

Cited by 53 publications

(28 citation statements)

References 11 publications

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“…While prior studies have described the coupling of chromatographic separations with electron impact sources (e.g., GC-EI-TOF-MS, 38 GC-EI-QLT-Orbitrap, 39 and GC-EI-FT-ICR MS 40,41 ), more recently, the GC and LC coupling to API-FT-ICR MS has shown advantages for the detection of molecular components and the separation of isomeric components (e.g., GC-APCI-FT-ICR MS, 15,42 and HPLC-ESI/APCI/APPI/APLI-FT-ICR MS 43,44 ).…”

Section: Introductionmentioning

confidence: 99%

Increasing Polyaromatic Hydrocarbon (PAH) Molecular Coverage during Fossil Oil Analysis by Combining Gas Chromatography and Atmospheric-Pressure Laser Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS)

et al. 2016

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Thousands of chemically distinct compounds are encountered in fossil oil samples that require rapid screening and accurate identification. In the present paper, we show for the first time, the advantages of gas chromatography (GC) separation in combination with atmospheric-pressure laser ionization (APLI) and ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for the screening of polyaromatic hydrocarbons (PAHs) in fossil oils. In particular, reference standards of organics in shale oil, petroleum crude oil, and heavy sweet crude oil were characterized by GC-APLI-FT-ICR MS and APLI-FT-ICR MS. Results showed that, while APLI increases the ionization efficiency of PAHs, when compared to other ionization sources, the complexity of the fossil oils reduces the probability of ionizing lower-concentration compounds during direct infusion. When gas chromatography precedes APLI-FT-ICR MS, an increase (more than 2-fold) in the ionization efficiency and an increase in the signal-to-noise ratio of lower-concentration fractions are observed, giving better molecular coverage in the m/z 100–450 range. That is, the use of GC prior to APLI-FT-ICR MS resulted in higher molecular coverage, higher sensitivity, and the ability to separate and characterize molecular isomers, while maintaining the ultrahigh resolution and mass accuracy of the FT-ICR MS separation.

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Section: Introductionmentioning

confidence: 99%

Increasing Polyaromatic Hydrocarbon (PAH) Molecular Coverage during Fossil Oil Analysis by Combining Gas Chromatography and Atmospheric-Pressure Laser Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS)

et al. 2016

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“…The first successful coupling of an FTMS and a capillary column gas chromatograph was achieved in 1980 (35) and elaborated and then linked with Fourier transform infrared in 1982 (36,37). It has been proposed that FTMS is well suited for high-resolution multiple ion monitoring (35). The obstacle for high resolution in the GC-MS mode is the high pressure in the trap, which results from admitting GC eluent and carrier gas.…”

Section: Sample Introduction and Ionizationmentioning

confidence: 99%

Fourier Transform Mass Spectrometry

Gross

Rempel

1984

Science

Self Cite

182

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Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.

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“…The FT-ICR mass spectrometer was custom-built for analytical method development [27] and consisted of a 1.2-tesla Varian electromagnet, a 4.76-cm cell, and either a Nicolet 2000 (Madison, WI) or a MIDAS ( M odular I CR D ata A cquisition S ystem, National High Magnetic Field Lab, Florida State University) data system. The MIDAS system consisted of a FT-ICR cell controller, an electron-gun controller, and a PC running MIDAS software, version 3.18.…”

Section: Methodsmentioning

confidence: 99%

Radical cation/radical reactions: A Fourier transform ion cyclotron resonance study of allyl radical reacting with aromatic radical cations

Russell

Rohrs

Read

et al. 2009

International Journal of Mass Spectrometry

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A method for the study of reactions of open-shell neutrals (radicals) and radical cations is described. Pyrolysis (25-1500 °C) of thermally labile compounds, such as, 1,5-hexadiene via a Chen nozzle yields a seeded beam of reactive species in helium. The pyrolysis products are then analyzed by electron ionization (EI) or reacted with stored ions. Electron ionization of the pyrolysis products of 1,5-hexadiene shows that both the allyl radical and allene are generated. Reactions of benzene radical cations and the pyrolysis products of 1,5-hexadiene result in carboncarbon bond formation. Those reactions of allyl radical with the benzene radical cation yield the C 7 H 7 + ion of m/z 91, permitting an unusual entry into arenium ions.

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Coupling of capillary gas chromatograph and Fourier transform mass spectrometer

Cited by 53 publications

References 11 publications

Increasing Polyaromatic Hydrocarbon (PAH) Molecular Coverage during Fossil Oil Analysis by Combining Gas Chromatography and Atmospheric-Pressure Laser Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS)

Increasing Polyaromatic Hydrocarbon (PAH) Molecular Coverage during Fossil Oil Analysis by Combining Gas Chromatography and Atmospheric-Pressure Laser Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS)

Fourier Transform Mass Spectrometry

Radical cation/radical reactions: A Fourier transform ion cyclotron resonance study of allyl radical reacting with aromatic radical cations

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