Coupling microchip pressure regulators with chipHPLC as a step toward fully portable analysis system

Svensson, Karolina; Weise, Chris; Westphal, Hannes; Södergren, Simon; Belder, Detlev; Hjort, Klas

doi:10.1016/j.snb.2023.133732

Cited by 8 publications

(5 citation statements)

References 67 publications

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“…To further reduce solvent usage, we integrated a chipHPLC-setup as a modular alternative to the commercially used C18-column (Fig. 4A; the simplified setup is based on a recent joint publication 88 ). Initially, the chipHPLC-setup was integrated, the injection principle visualised, and the duty cycle was automated similarly (detailed description in the ESI† in section S3).…”

Section: Resultsmentioning

confidence: 99%

“…A modified analytical section was later employed to enable chip-based separations as a fast but low-consumption alternative to the commercially used C18-column (the general chipHPLC-setup was based on a recent joint publication 88 ). For that purpose, the fluidic connections of the setup were modified according to Fig.…”

Section: Methodsmentioning

confidence: 99%

“…We integrated online analysis to enable continuous, long-term monitoring by coupling the system with LC/MS and implementing automated injections. Additionally, we propose miniaturising the analytical method using chipHPLC, leveraging our previous expertise in this area, [85][86][87][88] to significantly reduce solvent consumption in the analytical section and accelerate the separation time (Fig. 1).…”

Section: Reaction Chemistry and Engineering Papermentioning

confidence: 99%

“…ChipHPLC integration to the instrumental setup A modified analytical section was later employed to enable chip-based separations as a fast but low-consumption alternative to the commercially used C18-column (the general chipHPLC-setup was based on a recent joint publication 88 ). For that purpose, the fluidic connections of the setup were modified according to Fig.…”

Section: Reaction Chemistry and Engineering Papermentioning

confidence: 99%

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Development of an automated platform for monitoring microfluidic reactors through multi-reactor integration and online (chip-)LC/MS-detection

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Reaction Chemistry and Engineering Papermentioning

confidence: 99%

Section: Reaction Chemistry and Engineering Papermentioning

confidence: 99%

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Development of an automated platform for monitoring microfluidic reactors through multi-reactor integration and online (chip-)LC/MS-detection

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et al. 2024

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“…The developed system incorporates an HPLC and a spectrally wide absorption detector, which can identify all 24 PAHs on the priority pollutant list of the United States Environmental Protection Agency [141]. In addition, an alternative chipHLPC device using fluorescence and electrospray mass spectrometry (ESI-MS) was used to obtain a rapid and on-site separation of four PAHs [142]. Another microfluidic chromatography detection system was used to measure the concentrations of saccharin sodium (SAC) and acesulfame potassium (Ace-K) in 16 commercial food samples, providing rapid detection of artificial sweeteners in food [143].…”

Section: Portable Chromatography Solutions and Chromatography-on-chipmentioning

confidence: 99%

What Are We Eating? Surveying the Presence of Toxic Molecules in the Food Supply Chain Using Chromatographic Approaches

Casado,

Berenguer,

Câmara

et al. 2024

Molecules

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Consumers in developed and Western European countries are becoming more aware of the impact of food on their health, and they demand clear, transparent, and reliable information from the food industry about the products they consume. They recognise that food safety risks are often due to the unexpected presence of contaminants throughout the food supply chain. Among these, mycotoxins produced by food-infecting fungi, endogenous toxins from certain plants and organisms, pesticides, and other drugs used excessively during farming and food production, which lead to their contamination and accumulation in foodstuffs, are the main causes of concern. In this context, the goals of this review are to provide a comprehensive overview of the presence of toxic molecules reported in foodstuffs since 2020 through the Rapid Alert System for Food and Feed (RASFF) portal and use chromatography to address this challenge. Overall, natural toxins, environmental pollutants, and food-processing contaminants are the most frequently reported toxic molecules, and liquid chromatography and gas chromatography are the most reliable approaches for their control. However, faster, simpler, and more powerful analytical procedures are necessary to cope with the growing pressures on the food chain supply.

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Mass spectrometry coupling of chip-based supercritical fluid chromatography enabled by make-up flow-assisted backpressure regulation

Weise,

Fischer,

Belder

2024

Anal Bioanal Chem

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This work introduces a novel microfluidic backpressure pressure control developed for chip-based supercritical fluid chromatography (chipSFC). The presented on-chip pressure control mechanism involves the post-column addition of a viscous make-up stream, which enables pressure regulation within the range of 73 to 130 bar range. In contrast to approaches using mechanical backpressure regulators, this chip-based make-up-assisted pressure regulation offers a wear-free alternative that functions entirely through fluidic means and contributes minimally to extra column volume. It prevents phase separation of the supercritical mobile phase and, therefore, expands the analytical scope of chipSFC to detection systems with an ambient pressure interface. This was demonstrated by a proof-of-principle experiment, where a model mixture was separated within 30 s and detected using atmospheric pressure ionisation mass spectrometry. Graphical abstract

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Coupling microchip pressure regulators with chipHPLC as a step toward fully portable analysis system

Cited by 8 publications

References 67 publications

Development of an automated platform for monitoring microfluidic reactors through multi-reactor integration and online (chip-)LC/MS-detection

Development of an automated platform for monitoring microfluidic reactors through multi-reactor integration and online (chip-)LC/MS-detection

What Are We Eating? Surveying the Presence of Toxic Molecules in the Food Supply Chain Using Chromatographic Approaches

Mass spectrometry coupling of chip-based supercritical fluid chromatography enabled by make-up flow-assisted backpressure regulation

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