Coupling CO2 Reduction and Acetyl‐CoA Formation: The Role of a CO Capturing Tunnel in Enzymatic Catalysis
Jakob Ruickoldt,
Jae‐Hun Jeoung,
Maik Alexander Rudolph
et al.
Abstract:The bifunctional CO‐dehydrogenase/acetyl‐CoA synthase (CODH/ACS) complex couples the reduction of CO2 to the condensation of CO with a methyl‐moiety and CoA to acetyl‐CoA. Catalysis occurs at two sites connected by a tunnel transporting the CO. Here, we investigated how the bifunctional complex and its tunnel support catalysis using the CODH/ACS from Carboxydothermus hydrogenoformans as a model. Although CODH/ACS adapted to form a stable bifunctional complex with a secluded substrate tunnel, catalysis and CO t… Show more
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