Coupled systolic-ventricular and vascular stiffening with age

Chen, Chen Huan; Nakayama, Masaru; Nevo, Erez; Fetics, Barry; Maughan, W L; Kass, David A.

doi:10.1016/s0735-1097(98)00374-x

Cited by 399 publications

(98 citation statements)

References 38 publications

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“…The interaction of ventricular and arterial properties, or coupling, is an important and largely under-appreciated determinant of cardiac performance (1)(2)(3)9). Because cardiac reserve during maximal exertion decreases with increasing age in healthy humans (5), evaluation of rest and exercise ventricular-vascular coupling in a large, healthy cohort illuminates reasons for this decline.…”

Section: Discussionmentioning

confidence: 99%

“…Rather, EF is determined by the interaction of arterial and ventricular properties (1)(2)(3). Effective arterial elastance (EaI) is a steady-state arterial parameter that characterizes the functional properties of the arterial system by incorporating peripheral vascular resistance, total lumped vascular compliance, characteristic impedance, and systolic and diastolic time intervals (1).…”

mentioning

confidence: 99%

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Age and Gender Affect Ventricular-Vascular Coupling During Aerobic Exercise

Najjar

Schulman

Gerstenblith

et al. 2004

Journal of the American College of Cardiology

162

161

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Age and Gender Affect Ventricular-Vascular Coupling During Aerobic Exercise

Najjar

Schulman

Gerstenblith

et al. 2004

Journal of the American College of Cardiology

162

161

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show abstract

“…These changes occur concomitantly with a late augmentation index (AGI) of the carotid pressure pulse. An increase in arterial stiffness increases the vascular load on the heart, resulting in adverse changes in left ventricular (LV) structure and function (4), in part, by altering coupling efficiency between the vasculature and the heart (5). Epidemiologic studies in humans have shown that elevated measures of arterial stiffness are reliable predictors of cardiovascular morbidity and mortality (6).…”

mentioning

confidence: 99%

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

Vaitkevicius

Lane

Spurgeon

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

238

131

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“…First, a smaller body height has been associated with early return of reflected waves to the central aorta in systole rather than diastole (54), which causes a decrease in pulse wave amplification, exemplified by an increase in pulse pressure (55). Further attenuation in pulse pressure amplification has also been shown in postmenopausal women (12,56).…”

Section: Discussionmentioning

confidence: 99%

Increased Cardiovascular Stiffness and Impaired Age-related Functional Status

Andersen¹,

Kritchevsky

Morgan

et al. 2014

GERONA

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Our objective was to determine if increased cardiovascular (CV) stiffness is associated with disability in middle-aged and older adults at risk for congestive heart failure. CV stiffness (brachial pulse pressure/left ventricular stroke volume indexed to body surface area) and total disability (the summed assessment of activities of daily living, mobility, and instrumental activities of daily living) were measured in 445 individuals. A subset of 109 randomly selected individuals also underwent physical function testing. Total disability was associated with CV stiffness (p = .01), driven by an association with mobility (p = .005), but not activities of daily living (p = .13) or instrumental activities of daily living (p = .61). After accounting for age, these correlations remained significant for men (p = .04), but not for women. CV stiffness was also associated with increased 400-m walk time (p = .02). In middle-aged and elderly men at risk for congestive heart failure, CV stiffness is associated with decreased mobility and physical function, and increased overall disability.Key Words: Cardiovascular stiffness-Disability-Congestive heart failure. Decision Editor: Rafael de Cabo, PhDPhysical disability reduces quality of life, increases health care costs (due to increased need for support services), and is an independent predictor of mortality (1,2). Mobility and activities of daily living are necessary for maintaining basic independent functioning in middle-aged and older individuals (3). Therapy targeted to attenuate the factors that promote disability could improve quality of life and prognosis in older individuals. Such therapy could provide a mortality benefit, as it has been shown in the elderly individual that all levels of physical activity are associated with lower risk of incident acute myocardial infarction, stroke, and cardiovascular (CV) mortality (4). Previously, it has been shown that abnormally increased cardiac and aortic stiffness is independently associated with reduced peak exercise capacity in elderly individuals with and without left ventricular (LV) systolic dysfunction and congestive heart failure (CHF) (5-10). We hypothesized that similar to exercise capacity, increased CV stiffness would be associated with increased disability in middleaged and elderly individuals at risk for their first episode of symptomatic CHF. To test this hypothesis, we noninvasively assessed CV stiffness (using CV magnetic resonance or CMR) and disability. Additionally, in a randomly selected subgroup of individuals, we formally measured physical function.

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Coupled systolic-ventricular and vascular stiffening with age

Cited by 399 publications

References 38 publications

Age and Gender Affect Ventricular-Vascular Coupling During Aerobic Exercise

Age and Gender Affect Ventricular-Vascular Coupling During Aerobic Exercise

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

Increased Cardiovascular Stiffness and Impaired Age-related Functional Status

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