Coupled production and emission of short chain perfluoroalkyl acids from a fast developing fluorochemical industry: Evidence from yearly and seasonal monitoring in Daling River Basin, China

Wang, Pei; Lü, Yonglong; Wang, Tieyu; Zhu, Zhaoyun; Li, Qifeng; Meng, Jing; Su, Hongqiao; Johnson, Andrew C.; Sweetman, Andrew J.

doi:10.1016/j.envpol.2016.08.079

Cited by 72 publications

(17 citation statements)

References 21 publications

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“…Perfluorobutanesulfonic acid (PFBS) is an emerging toxicant of international interest, becoming increasingly concentrated in both the environment (Chen et al, 2017;Shao et al, 2016;Wang et al, 2016) and in biological samples (Glynn et al, 2012;Huang et al, 2018) due to increased manufacture and use. PFBS and its derivatives are used in the manufacture of surfactants, such as Scotchgard, metal plating, flame retardants, and fire-fighting foams (Wang et al, 2013).…”

mentioning

confidence: 99%

Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio

Sant

Venezia

Sinno

et al. 2018

Toxicological Sciences

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Since phase-out of highly persistent perfluorosulfonates in the U.S. from non-stick and stain-resistant products in the early 2000s, perfluorobutanesulfonic acid (PFBS) has replaced these compounds as a primary surfactant. Measurements of PFBS in environmental and human samples have been rising in recent years, raising concerns about potential negative health effects. We previously found that embryonic exposures to a related compound, perfluorooctanesulfonic acid (PFOS), decreased pancreas length and insulin-producing islet area in zebrafish embryos (Danio rerio). The objective of this study was to compare the effects of PFBS exposures on pancreatic organogenesis with our previous PFOS findings. Dechorionated zebrafish embryos from two different transgenic fish lines (Tg(insulin:GFP), Tg(ptf1a:GFP)) were exposed to 0 (0.01% DMSO), 16, or 32 µM PFBS daily beginning at 1 day post fertilization (dpf) until 4 and 7 dpf when they were examined using fluorescent microscopy for islet area and morphology, and exocrine pancreas length. PFBS-exposed embryos had significantly increased caudal fin deformities, delayed swim bladder inflation, and impaired yolk utilization. Incidence of fish with significantly stunted growth and truncated exocrine pancreas length was significantly increased, although these two effects occurred independently. Islet morphology revealed an increased incidence of severely hypomorphic islets (areas lower than the 1st percentile of controls) and an elevated occurrence of fragmented islets. RNA Seq data (4 dpf) also identify disruptions in regulation of lipid homeostasis. Overall, this work demonstrates that PFBS exposure can perturb embryonic development, energy homeostasis, and pancreatic organogenesis.

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confidence: 99%

Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio

Sant

Venezia

Sinno

et al. 2018

Toxicological Sciences

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“…However, besides these developments, short chain PFCAs did not receive the same scientific and public attention. Today, we know that short chain PFCAs are produced and emitted in significant amounts, e.g., for use in formulations replacing the C8 based chemistry (Wang et al, 2016 ). Thus more attention will be directed to substances such as trifluoroacetic acid (TFA), perfluoropropanoic acid (PFPrA), perfluorobutanoic acid (PFBA), and perfluorobutane sulfonic acid (PFBS).…”

Section: Mobilitymentioning

confidence: 99%

Four Chemical Trends Will Shape the Next Decade's Directions in Perfluoroalkyl and Polyfluoroalkyl Substances Research

Kotthoff

Bücking

2018

Front. Chem.

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Per- and polyfluoroalkyl substances (PFAS) represent a versatile group of ubiquitously occurring chemicals of increasing regulatory concern. The past years lead to an ever expanding portfolio of detected anthropogenic PFAS in numerous products encountered in daily life. Yet no clear picture of the full range of individual substance that comprise PFAS is available and this challenges analytical and engineering sciences. Authorities struggle to cope with uncertainties in managing risk of harm posed by PFAS. This is a result of an incomplete understanding of the range of compounds that they comprise in differing products. There are analytical uncertainties identifying PFAS and estimating the concentrations of the total PFAS load individual molecules remain unknown. There are four major trends from the chemical perspective that will shape PFAS research for the next decade. Mobility: A wide and dynamic distribution of short chain PFAS due to their high polarity, persistency and volatility.Substitution of regulated substances: The ban or restrictions of individual molecules will lead to a replacement with substitutes of similar concern.Increase in structural diversity of existing PFAS molecules: Introduction of e.g., hydrogens and chlorine atoms instead of fluorine, as well as branching and cross-linking lead to a high versatility of unknown target molecules.Unknown “Dark Matter”: The amount, identity, formation pathways, and transformation dynamics of polymers and PFAS precursors are largely unknown.These directions require optimized analytical setups, especially multi-methods, and semi-specific tools to determine PFAS-sum parameters in any relevant matrix.

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“…However, the regulations on PFOS, PFOA and related compounds result in a sharp increase in demand for other PFAAs in the market. This shift in production and application could be imaged by the contamination profiles and trends of PFAAs in the environment [34,35]. For instance, PFHxS, rather than PFOS or PFOA, was predominant in the surface water in Taihu Lake in recent years [36].…”

Section: Introductionmentioning

confidence: 99%

Occurrence, Removal and Bioaccumulation of Perfluoroalkyl Substances in Lake Chaohu, China

Pan

Zhang³

et al. 2019

IJERPH

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The perfluoroalkyl substances (PFAAs) have received growing attention in recent years as emerging contaminants in the aquatic environment. The occurrence, removal and bioaccumulation of fourteen PFAAs (C4–C14 carboxylate; C4, C6, C8 sulfonates) were investigated in Lake Chaohu, China. The concentrations of the selected PFAAs in inflowing river, lake water and sewage treatment plant (STP) samples were analyzed by ultra performance liquid chromatograph (UPLC–MS/MS). The results showed that perfluorohexanesulfonic acid (PFHxS), perfluorobutane sulfonate (PFBS), perfluorobutyric acid (PFBA) and perfluoropentanoic acid (PFPeA), instead of perfluorooctanoic acid (PFOA), were predominant PFAAs in the inflowing river and lake water with maximum concentrations in the ranges of 52.2–1866 and 27–236 ng L−1, respectively. The highest concentrations of total PFAAs were detected in the western rivers. The effluents from seven STPs were likely important sources of PFAAs in surface water, and the amount of the daily fluxes in the effluent were 132 g for short-chain PFAAs and 109 g for long-chain PFAAs. PFAAs were widely detected in Chinese icefish (Neosalanx tangkahkeii taihuensis) collected from Lake Chaohu, with maximal concentrations ranging from 1.79 ng g−1 to 50.9 ng g−1. The logarithmic bioaccumulation factors of perfluorodecanoic acid (PFDA, 3.5), perfluorooctane sulfonate (PFOS, 3.35) and perfluorononanoic acid (PFNA, 3.31) indicated the bioaccumulation of these long-chain PFAAs. This study is useful for enhancing our understanding of the pollution profiles of PFAAs and their environmental health risk in the freshwater lake.

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Coupled production and emission of short chain perfluoroalkyl acids from a fast developing fluorochemical industry: Evidence from yearly and seasonal monitoring in Daling River Basin, China

Cited by 72 publications

References 21 publications

Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio

Perfluorobutanesulfonic Acid Disrupts Pancreatic Organogenesis and Regulation of Lipid Metabolism in the Zebrafish, Danio rerio

Four Chemical Trends Will Shape the Next Decade's Directions in Perfluoroalkyl and Polyfluoroalkyl Substances Research

Occurrence, Removal and Bioaccumulation of Perfluoroalkyl Substances in Lake Chaohu, China

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