Country-wide HIV incidence study complementing HIV surveillance in Germany

Bätzing-Feigenbaum, Jörg; Loschen, Stephan; Gohlke-Micknis, Silvia; Zimmermann, Ruth; Herrmann, Antoinette; Wambo, G. O. Kamga; Kücherer, Claudia; Hamouda, Osamah

doi:10.2807/ese.13.36.18971-en

Cited by 16 publications

References 13 publications

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Longitudinal trends of recent HIV-1 infections in Slovenia (1986-2012) determined using an incidence algorithm

et al. 2015

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Resolving dilemma whether the rise in the number of HIV diagnoses represents an actual increase in HIV transmissions or is a result of improved HIV surveillance is crucial before implementing national HIV prevention strategies. Annual proportions of recent infections (RI) among newly diagnosed persons infected with HIV-1 in Slovenia during 27 years (1986-2012) were determined using an algorithm consisting of routine baseline CD4 and HIV viral load measurements and the Aware BED EIA HIV-1 Incidence Test (BED test). The study included the highest coverage of persons diagnosed with HIV during the entire duration of an HIV epidemic in a given country/region (71%). Out of 416 patients, 170 (40.9%) had a baseline CD4 cell count less than 200 cells/mm(3) and/or HIV-1 viral load less than 400 copies/ml and were characterized as having a long-standing infection (LSI). The remaining 246 patients were additionally tested using the BED test. Overall, 23% (97/416) of the patients were labeled RI. The characteristics significantly associated with RI were as follows: younger age, acute retroviral syndrome, CDC class A and other than C, no AIDS defining illnesses, HIV test performed in the past, a higher viral load, and a higher CD4 cell count. An interesting trend in the proportion of RI was observed, with a peak in 2005 (47% of RI) and the lowest point in 2008 (12%) in parallel with a rise in the numbers of new HIV diagnoses. This study could help promote the idea of introducing periodic HIV incidence monitoring using a simple and affordable algorithm.

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Longitudinal trends of recent HIV-1 infections in Slovenia (1986-2012) determined using an incidence algorithm

et al. 2015

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Infektionskrankheiten

Schwegler

Fritze²,

Fritze

et al. 2012

Die Ärztliche Begutachtung

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Virale Infektionen zählen immer noch weltweit, besonders in den Entwicklungsländern, zu den häufigsten Todesursachen. Durch internationale systematische Impfkampagnen der WHO ist die Welt Pocken-frei geworden. Die Inzidenz der Infektionen, die durch eine Immunprophylaxe verhindert werden können, wurde drastisch gesenkt (Poliomyelitis, Tollwut). In den 1980er Jahren trat eine neue Tierseuche beim Rind auf, die bovine spongyforme Enzephalopathie (BSE), die mit der neuen Variante der Creutzfeldt-Jakob-Krankheit (vCJK) in Zusammenhang steht (Nahrungskette). Im selben Zeitraum begann die explosionsartige weltweite Verbreitung eines neuen Retrovirus, des HIV. Trotz intensiver Aufklärungskampagnen und neuen therapeutischen Möglichkeiten (HAART, hoch aktive antiretrovirale Therapie) ist es bis zur Jahrtausendwende nicht gelungen, die weitere Ausbreitung der HIV-Infektion zu verhindern. Seit 2007 ist eine allmähliche Eindämmung der Infektion zu erkennen, die Neuinfektionen sind weltweit rückläufig. Durch den breiteren Einsatz der HAART sind Lebensqualität und Lebenserwartung enorm gestiegen, die Sterberate der AIDS-Infizierten ist seit 2005 um mehr als 50 % zurückgegangen.

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High Percentage of Recent HIV Infection Leading to Onward Transmission in Odessa, Ukraine Associated with Young Adults

Simmons

Semenenko²,

Tolpina³

et al. 2013

AIDS Behav

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The proportion of new HIV diagnoses between May and December 2009 across Odessa recently-infected was estimated using the BED-CEIA assay. Logistic regression models were used to explore factors associated with testing as recent. Of 1,313 newly-diagnosed individuals, 321 (24 %) were classified as recent. Recent infection was less likely among older adults [odds ratio (OR) = 0.70 per 10-year increase, 95 % CI 0.60-0.82]. Compared to men residing in Odessa city, women in rural Odessa and non-resident men were more likely to be recently-infected (OR 1.85, 1.26-2.71 and 2.83, 1.15-6.97, respectively). Reason for test was not associated with recent infection. In sensitivity analysis, after excluding individuals tested due to clinical indications, the proportion recently-infected and the association with age remained virtually unchanged. Our findings suggest a high risk of onward transmission, particularly in younger age groups. These findings highlight the need for tailored prevention strategies and ongoing RITA testing to monitor and evaluate effectiveness of prevention programmes.

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Country-wide HIV incidence study complementing HIV surveillance in Germany

Cited by 16 publications

References 13 publications

Longitudinal trends of recent HIV-1 infections in Slovenia (1986-2012) determined using an incidence algorithm

Longitudinal trends of recent HIV-1 infections in Slovenia (1986-2012) determined using an incidence algorithm

Infektionskrankheiten

High Percentage of Recent HIV Infection Leading to Onward Transmission in Odessa, Ukraine Associated with Young Adults

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