Counting the water: Characterize the hydration level of aluminum adjuvants using contrast matching small-angle neutron scattering

Xu, Amy Y.; Rinee, Khaleda C.; Stemple, Carrie; Castellanos, Maria Monica; Bakshi, Kunal; Krueger, Susan; Curtis, Joseph E.

doi:10.1016/j.colsurfa.2022.129285

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“…At the microscopic scale, however, aluminum microparticles of vaccines undergo various changes upon F/T, such as dehydration and loss of hydroxyls at the particle surface, antigen desorption and particle agglomeration. 7–9 …”

Section: Introductionmentioning

confidence: 99%

Sedimentation behavior of quality and freeze-damaged aluminum-adjuvanted vaccines by w NMR

Briggs

Taraban

2023

Human Vaccines & Immunotherapeutics

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Vaccine sedimentation and resuspension are properties that vaccine makers use to characterize a suspension product during research and development as well as throughout the shelf life of the vaccine. Three vaccines with three different aluminum adjuvants and different antigens were selected and monitored over the course of sedimentation using water proton nuclear magnetic resonance ( w NMR) relaxometry. This simple method measured fully intact, single-dose vaccine vials and reported sedimentation profiles for each, which readily distinguished freeze-stressed vaccines from unstressed vaccines.

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Section: Introductionmentioning

confidence: 99%