Counting Acetylcholine Receptors in the Electroplax

Karlin, Arthur; Prives, Joav; Deal, Walter J.; Winnik, Mitchell A.

doi:10.1002/9780470719763.ch12

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Search For Specific Ligands: Affinity Labeling1

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Cited by 14 publications

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“…Several new affinity ligands were designed on this basis together with Silman. Attempts to use radiolabeled MPTA to count nAChR sites in the electroplaque appeared encouraging [32], but as stated by Karlin himself, and as in the case of TDF the "specificity was not complete" (p. 260) to efficiently pursue the identification of the receptor. Yet, years later, MPTA successfully led to the identification of the first amino acid from the acetylcholine binding site [33].…”

Section: Search For Specific Ligands: Affinity Labelingmentioning

confidence: 99%