Counterselection on sex chromosomes in the <i>Mus musculus</i> European hybrid zone

Dod, Barbara; Jermiin, Lars S.; Boursot, Pierre; Chapman, Verne H.; Nielsen, Jörn; Bonhomme, François

doi:10.1046/j.1420-9101.1993.6040529.x

Cited by 153 publications

(165 citation statements)

References 22 publications

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“…Furthermore, a balance between gene flow and selection against hybrids often leads to the formation of narrow hybrid zones, reducing recombination and therefore allowing divergence between populations either side of the zone to continue (parapatric speciation; Kondrashov, 2003). Clines of sex-linked loci are often narrower than those of autosomal loci, for example in the house mouse (Tucker et al, 1992;Dod et al, 1993Dod et al, , 2005Raufaste et al, 2005;Macholán et al, 2007), indicating either that selection against hybrids is more efficient on the X/Z chromosome or that it is more likely to contain genes selected against in hybrids. Either way, recombination in parapatry is lower for X/Z-linked loci than autosomal loci, increasing their potential for divergence.…”

Section: Evolution Of Genetic Incompatibilitymentioning

confidence: 99%

Speciation through evolution of sex-linked genes

2008

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Identification of genes involved in reproductive isolation opens novel ways to investigate links between stages of the speciation process. Are the genes coding for ecological adaptations and sexual isolation the same that eventually lead to hybrid sterility and inviability? We review the role of sex-linked genes at different stages of speciation based on four main differences between sex chromosomes and autosomes; (1) relative speed of evolution, (2) non-random accumulation of genes, (3) exposure of incompatible recessive genes in hybrids and (4) recombination rate. At early stages of population divergence ecological differences appear mainly determined by autosomal genes, but fastevolving sex-linked genes are likely to play an important role for the evolution of sexual isolation by coding for traits with sex-specific fitness effects (for example, primary and secondary sexual traits). Empirical evidence supports this expectation but mainly in female-heterogametic taxa. By contrast, there is clear evidence for both strong X-and Z-linkage of hybrid sterility and inviability at later stages of speciation. Hence genes coding for sexual isolation traits are more likely to eventually cause hybrid sterility when they are sex-linked. We conclude that the link between sexual isolation and evolution of hybrid sterility is more intuitive in male-heterogametic taxa because recessive sexually antagonistic genes are expected to quickly accumulate on the X-chromosome. However, the broader range of sexual traits that are expected to accumulate on the Z-chromosome may facilitate adaptive speciation in female-heterogametic species by allowing male signals and female preferences to remain in linkage disequilibrium despite periods of gene flow.

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Section: Evolution Of Genetic Incompatibilitymentioning

confidence: 99%

Speciation through evolution of sex-linked genes

2008

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“…For example, loci contributing to reproductive isolation in animals are disproportionately found on particular chromosomes (e.g., chromosome 17 in mice; Yeom et al 1992) and in this context, the X chromosome plays an important role (Coyne and Orr 1989). Moreover, X-linked markers show reduced introgression across a number of mouse hybrid zones (Tucker et al 1992;Dod et al 1993;Payseur et al 2004;Payseur and Nachman 2005). In the S. araneus group, the sex chromosome system in males is unusual (i.e., XY1Y2), and only the smallest arm e can be considered as the real X chromosome (Zima et al 1998).…”

Section: Variation Across Locimentioning

confidence: 99%

Restricted Gene Flow at Specific Parts of the Shrew Genome in Chromosomal Hybrid Zones

et al. 2006

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Abstract. The species and races of the shrews of the Sorex araneus group exhibit a broad range of chromosomal polymorphisms. European taxa of this group are parapatric and form contact or hybrid zones that span an extraordinary variety of situations, ranging from absolute genetic isolation to almost free gene flow. This variety seems to depend for a large part on the chromosome composition of populations, which are primarily differentiated by various Robertsonian fusions of a subset of acrocentric chromosomes. Previous studies suggested that chromosomal rearrangements play a causative role in the speciation process. In such models, gene flow should be more restricted for markers on chromosomes involved in rearrangements than on chromosomes common in both parent species. In the present study, we address the possibility of such differential gene flow in the context of two genetically very similar but karyotypically different hybrid zones between species of the S. araneus group using microsatellite loci mapped to the chromosome arm level. Interspecific genetic structure across rearranged chromosomes was in general larger than across common chromosomes. However, the difference between the two classes of chromosomes was only significant in the hybrid zone where the complexity of hybrids is expected to be larger. These differences did not distinguish populations within species. Therefore, the rearranged chromosomes appear to affect the reproductive barrier between karyotypic species, although the strength of this effect depends on the complexity of the hybrids produced.

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“…The subspecies meet in a well-studied zone of secondary contact that stretches across central Europe Sage et al 1993), where diagnostic allele frequencies shift rapidly over short geographic distances Sage et al 1993). Individual loci often exhibit marked reductions in gene flow (Vanlerberghe et al 1986;Dod et al 1993;Munclinger et al 2002;Payseur et al 2004;Dod et al 2005;Payseur and Nachman 2005;Raufaste et al 2005;Macholán et al 2007Macholán et al , 2008Teeter et al 2008Teeter et al , 2010, as expected for genomic regions involved in reproductive isolation (Payseur 2010). Hybrids sampled from this zone show signs of reduced fitness, including increased parasite loads (Sage et al 1986;Moulia et al 1991Moulia et al , 1993.…”

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confidence: 98%

Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

et al. 2011

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Reproductive isolation between species is often caused by deleterious interactions among loci in hybrids. Finding the genes involved in these incompatibilities provides insight into the mechanisms of speciation. With recently diverged subspecies, house mice provide a powerful system for understanding the genetics of reproductive isolation early in the speciation process. Although previous studies have yielded important clues about the genetics of hybrid male sterility in house mice, they have been restricted to F 1 sterility or incompatibilities involving the X chromosome. To provide a more complete characterization of this key reproductive barrier, we conducted an F 2 intercross between wild-derived inbred strains from two subspecies of house mice, Mus musculus musculus and Mus musculus domesticus. We identified a suite of autosomal and X-linked QTL that underlie measures of hybrid male sterility, including testis weight, sperm density, and sperm morphology. In many cases, the autosomal loci were unique to a specific sterility trait and exhibited an effect only when homozygous, underscoring the importance of examining reproductive barriers beyond the F 1 generation. We also found novel two-locus incompatibilities between the M. m. musculus X chromosome and M. m. domesticus autosomal alleles. Our results reveal a complex genetic architecture for hybrid male sterility and suggest a prominent role for reproductive barriers in advanced generations in maintaining subspecies integrity in house mice.

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Counterselection on sex chromosomes in the Mus musculus European hybrid zone

Cited by 153 publications

References 22 publications

Speciation through evolution of sex-linked genes

Speciation through evolution of sex-linked genes

Restricted Gene Flow at Specific Parts of the Shrew Genome in Chromosomal Hybrid Zones

Genetic Dissection of a Key Reproductive Barrier Between Nascent Species of House Mice

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