Counterpropagating wave acoustic particle manipulation device for the effective manufacture of composite materials

Scholz, Marc-S.; Drinkwater, Bruce W.; Llewellyn-Jones, Thomas M.; Trask, Richard S.

doi:10.1109/tuffc.2015.007116

Cited by 27 publications

(30 citation statements)

References 30 publications

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“…Scholz, et al has demonstrated 13 that the acoustic patterning of various spherical and cylindrical microparticles was generated near the bottom surface of the device due to the high force distribution. To better define the optimum parameters for acoustic trapping of live cells and to help predict their behaviour under ultrasonic conditions, deposition studies were thus carried out.…”

Section: Resultsmentioning

confidence: 99%

“…In this work the transducers were operated away from their resonance (closer to anti-resonance) such that these cavity resonances will dominate the trapping field. A thorough experimental and theoretical finite element analysis of the operation of this type of device was given by Scholz et al 13 . Their results demonstrate the existence of the standing wave field but also show that it is confined to a thin layer above the bottom plate.…”

Section: Cancer and Non-cancer Cell Viability And Metabolic Activitymentioning

confidence: 99%

“…Moreover, high intensity focused ultrasound (HIFU) is used for tumor treatment via localized hyperthermia or tissue ablation 5,[9][10][11] . Recently, ultrasonic devices have been developed for cell manipulation for on-chip patterning 12,13 where a well-defined spatial distribution is important for tissue engineering 14 and developmental biology research 15 .…”

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confidence: 99%

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Effect of acoustic standing waves on cellular viability and metabolic activity

Levario-Diaz

Bhaskar

Galan

et al. 2020

Sci Rep

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Acoustic standing wave devices offer excellent potential applications in biological sciences for drug delivery, cell manipulation and tissue engineering. However, concerns have been raised about possible destructive effects on cells due to the applied acoustic field, in addition to other produced secondary factors. Here, we report a systematic study employing a 1D resonant acoustic trapping device to evaluate the cell viability and cell metabolism for a healthy cell line (Human Dermal Fibroblasts, HDF) and a cervical cancer cell line (HeLa), as a function of time and voltages applied (4-10 V pp) under temperature-controlled conditions. We demonstrate that high cell viability can be achieved reliably when the device is operated at its minimum trapping voltage and tuned carefully to maximise the acoustic standing wave field at the cavity resonance. We found that cell viability and reductive metabolism for both cell lines are kept close to control levels at room temperature and at 34 °C after 15 minutes of acoustic exposure, while shorter acoustic exposures and small changes on temperature and voltages, had detrimental effects on cells. Our study highlights the importance of developing robust acoustic protocols where the operating mode of the acoustic device is well defined, characterized and its temperature carefully controlled, for the application of acoustic standing waves when using live cells and for potential clinical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Cancer and Non-cancer Cell Viability And Metabolic Activitymentioning

confidence: 99%

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Effect of acoustic standing waves on cellular viability and metabolic activity

Levario-Diaz

Bhaskar

Galan

et al. 2020

Sci Rep

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“…3D fluorescence confocal image stacks of the 1D micropatterned monoliths revealed that the stripe patterns originated from density differences in the hydrogel network, and extended ≈70 µm in height from the underlying substrate before becoming incoherent (Figure c,d). We attributed this to the progressive reduction in the acoustic pressure field along the vertical direction of the sample chamber and disintegration of the nontrapped coacervate microdroplets present in these low‐pressure regions into a disordered hydrogel network . In contrast, the stripe patterns produced at the base of the hydrogels were attributed to immobilization of the coacervate microdroplets at the acoustic nodal points due to their strong interaction with the surface of the sample cavity.…”

mentioning

confidence: 99%

Fabrication of Micropatterned Dipeptide Hydrogels by Acoustic Trapping of Stimulus‐Responsive Coacervate Droplets

Nichols

Kumar

Bassindale

et al. 2018

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Acoustic standing waves offer an excellent opportunity to trap and spatially manipulate colloidal objects. This noncontact technique is used for the in situ formation and patterning in aqueous solution of 1D or 2D arrays of pH-responsive coacervate microdroplets comprising poly(diallyldimethylammonium) chloride and the dipeptide N-fluorenyl-9-methoxy-carbonyl-D-alanine-D-alanine. Decreasing the pH of the preformed droplet arrays results in dipeptide nanofilament self-assembly and subsequent formation of a micropatterned supramolecular hydrogel that can be removed as a self-supporting monolith. Guest molecules such as molecular dyes, proteins, and oligonucleotides are sequestered specifically within the coacervate droplets during acoustic processing to produce micropatterned hydrogels containing spatially organized functional components. Using this strategy, the site-specific isolation of multiple enzymes to drive a catalytic cascade within the micropatterned hydrogel films is exploited.

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“…The majority of previous work in acoustic particle assembly is based on acoustic resonators, which arrange many particles along extended traps that coincide with either nodes or antinodes of the standing pressure waves . The attainable shapes depend on acoustic modes of the chamber or superpositions of those.…”

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confidence: 99%

Acoustic Fabrication via the Assembly and Fusion of Particles

et al. 2017

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Acoustic assembly promises a route toward rapid parallel fabrication of whole objects directly from solution. This study reports the contact-free and maskless assembly, and fixing of silicone particles into arbitrary 2D shapes using ultrasound fields. Ultrasound passes through an acoustic hologram to form a target image. The particles assemble from a suspension along lines of high pressure in the image due to acoustic radiation forces and are then fixed (crosslinked) in a UV-triggered reaction. For this, the particles are loaded with a photoinitiator by solvent-induced swelling. This localizes the reaction and allows the bulk suspension to be reused. The final fabricated parts are mechanically stable and self-supporting.

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Counterpropagating wave acoustic particle manipulation device for the effective manufacture of composite materials

Cited by 27 publications

References 30 publications

Effect of acoustic standing waves on cellular viability and metabolic activity

Effect of acoustic standing waves on cellular viability and metabolic activity

Fabrication of Micropatterned Dipeptide Hydrogels by Acoustic Trapping of Stimulus‐Responsive Coacervate Droplets

Acoustic Fabrication via the Assembly and Fusion of Particles

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