Counterion-enhanced cyanine dye loading into lipid nano-droplets for single-particle tracking in zebrafish

Kilin, Vasyl; Anton, Halina; Anton, Nicolas; Steed, Emily; Vermot, Julien; Vandamme, Thierry F.; Mély, Yves; Klymchenko, Andrey S.

doi:10.1016/j.biomaterials.2014.02.053

Cited by 64 publications

(75 citation statements)

References 46 publications

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“…Klymchenko et al (2012) and (Kilin et al 2014) reported that highly lipophilic fluorescent components can be encapsulated in the lipophilic core of stable nanoemulsion droplets at high concentrations, to be used in diagnostic imaging for the visualization of vasculature.…”

Section: Emulsionsmentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

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In recent years, the use of commercial nanoparticles in different industry and health fields has increased exponentially. However, the uncontrolled application of nanoparticles might present a potential risk to the environment and health. Toxicity of these nanoparticles is usually evaluated by a fast screening assay in zebrafish (Danio rerio). The use of this vertebrate animal model has grown due to its small size, great adaptability, high fertilization rate and fast external development of transparent embryos. In this review, we describe the toxicity of different micro-and nanoparticles (carbon nanotubes, dendrimers, emulsions, liposomes, metal nanoparticles, and solid lipid nanoparticles) associated to their biophysical properties using this model. The main biophysical properties studied are size, charge and surface potential due to their impact on the environment and health effects. The review also discusses the correlation of the effects of the different nanoparticles on zebrafish. Special focus is made on morphological abnormalities, altered development and abnormal behavior. The last part of the review debates changes that should be made in future directions in order to improve the use of the zebrafish model to assess nanotoxicity.

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Section: Emulsionsmentioning

confidence: 99%

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

et al. 2017

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“…Lastly, organic dyes in organic solvent have been directly used as biological imaging agents after being encapsulated into a nano-sized droplet. 42, 43 The liquid state of the droplet prevents the ACQ effect of encapsulated dyes from occurring while the nano-sized core ensures a high loading capacity of dyes. As a result, highly fluorescent nano-sized droplets could be made.…”

Section: Design and Synthesis Of Soft Fluorescent Npsmentioning

confidence: 99%

“…In contrast, a type of nanoemulsion with a liquid core has been developed by nanoemulsification, a modified miniemulsion method. 42, 43, 80 In this method, a water-immiscible solvent is preserved as the oily core of the nano-sized droplets rather than be evaporated. This oily core functions as a reservoir for encapsulation of lipophilic dyes.…”

Section: Design and Synthesis Of Soft Fluorescent Npsmentioning

confidence: 99%

“…The extremely bright droplets (90 nm) containing ~12,000 cyanine molecules, were 100-fold brighter than quantum dots. 43 …”

Section: Design and Synthesis Of Soft Fluorescent Npsmentioning

confidence: 99%

“…The particles are stabilized by either surfactants, 43, 56 amphiphilic polymers 78 or PEG 41, 93 . By tracking the fluorescent trail of organic NPs, objects of interest can be imaged in vivo .…”

Section: Biological and Biomedical Applicationsmentioning

confidence: 99%

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Soft fluorescent nanomaterials for biological and biomedical imaging

2015

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Soft fluorescent nanomaterials have attracted recent attention as imaging agents for biological applications, because they provide the advantages of good biocompatibility, high brightness, and easy biofunctionalization. Here, we provide a survey of recent developments in fluorescent soft nano-sized biological imaging agents. Various soft fluorescent nanoparticles (NPs) (including dye-doped polymer NPs, semiconducting polymer NPs, small-molecule organic NPs, nanogels, micelles, vesicles, and biomaterial-based NPs) are summarized from the perspectives of preparation method, structure, optical property, and surface functionalization. Based on both optical and functional properties of the nano-sized imaging agents, their applications are then reviewed in terms of in vitro imaging, in vivo imaging, and cellular-process imaging, by means of specific or nonspecific targeting.

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Characterization and Safety Assessment of Oil‐in‐water Nanosized Emulsions

Rahman

Shunmugaperumal

2020

Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting

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Counterion-enhanced cyanine dye loading into lipid nano-droplets for single-particle tracking in zebrafish

Cited by 64 publications

References 46 publications

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Relation between biophysical properties of nanostructures and their toxicity on zebrafish

Soft fluorescent nanomaterials for biological and biomedical imaging

Characterization and Safety Assessment of Oil‐in‐water Nanosized Emulsions

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