Counterfeit Pennies: Distinguishing Chromoblastomycosis From Phaeohyphomycotic Infections

Skupsky, Hadas; Junkins‐Hopkins, Jacqueline M.

doi:10.1097/dad.0000000000000679

Cited by 6 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chromoblastomycosis is an implantation mycosis caused by pigmented saprophytic fungi [1]. The organism enters through breaks in the skin barrier and then presents with skin lesions after a variable time frame, ranging from several weeks to months.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chromoblastomycosis Caused by Fonsecaea monophora Mimicking Lichen Planus

Oprea,

Stringer,

Mattis

et al. 2024

Cureus

View full text Add to dashboard Cite

Chromoblastomycosis is a rare fungal infection acquired by traumatic inoculation of pigmented fungi from an environmental source. The polymorphic presentation of chromoblastomycosis may mimic other dermatologic conditions, leading to delays in diagnosis. Thus, histopathology is critical in identifying the presence of fungi and confirming the diagnosis. We present a case of chromoblastomycosis caused by the organism Fonsecaea monophora mimicking a lesion of lichen planus to highlight the importance of histopathology in the diagnosis of this condition.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Chromoblastomycosis is a saprophytic fungal infection endemic to the equatorial regions of the world and is associated with occupational risk factors such as agriculture, outdoor exposure, and natural disasters [1,2]. Due to its increased prevalence in tropical and subtropical areas, few cases have been reported in North America.…”

Section: Introductionmentioning

confidence: 99%

Chromoblastomycosis Caused by Fonsecaea monophora Mimicking Lichen Planus

Oprea,

Stringer,

Mattis

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…In terms of histological evaluation, care should be taken to exclude concomitant fungal infection (Paracoccidioidomycosis) and fungal mimickers such as Phaeohyphomycosis with "copper penny" spore-like organisms, commonly seen as dermal-based pseudocyst, an abscess or ulcerated necrotic granulomas [27,28]. Anecdotal reports have also described melanoma as a mimicker [17].…”

Section: Discussionmentioning

confidence: 99%

Chromoblastomycosis successfully treated with the combination of itraconazole and 5-flucytosine

Lima-Neto

Mohammadi

2023

Cell. Mol. Biomed. Rep.

View full text Add to dashboard Cite

Chromoblastomycosis (CBM) is a fungal disease, distributed in tropical and subtropical regions, affecting mainly rural workers. It is characterized by chronic skin lesions that may vary from nodular, tumorous, verrucous or plaque type. Associated constitutional symptoms are rarely found. The histological presentation may yield a pathognomonic feature, the Medlar (sclerotic) bodies, in which a typical brown to black pigment is depicted, explaining "copper pennies" as its alias. In this article, the case of a 56-year-old woman in the countryside of Brazil is reported; whose main complaint was a chronic leg ulcer for the past 8 years. On the left leg, a large, partially ulcerated plaque lesion was found. Microbiological cultures were positive for the pathogen. Histological analysis demonstrated pseudoepitheliomatous hyperplasia, lymphohistiocytic infiltrate and sclerotic bodies ("copper pennies"). CBM's epidemiological panorama, once established uniquely by geographical distribution, is transitioning to a global health issue, influenced by immunosuppressive conditions, global warming and migration. This scenario demands CBM to be widely considered as a differential diagnosis and may represent a clinical challenge in regions whose professionals have little expertise in infectious tropical diseases.

show abstract

“…The histopathology characteristically shows a circumscribed pseudocyst or abscess with chronic granulomatous inflammation. 4 Organisms can be hyphae, yeast-like, or both. Our patient's initial biopsy exhibited PEH, which is more consistent with chromoblastomycosis.…”

Section: Discussionmentioning

confidence: 99%

“…Organisms causing chromoblastomycosis are commonly found in the soil of tropical and subtropical areas. 4 Trauma typically precedes implantation and may present as a slowly enlarging nodule. Histopathologically, PEH and granulomatous inflammation are seen, with the pathognomonic “copper pennies,” or “Medlar bodies,” representing the intermediate vegetative form between yeast and hyphae.…”

Section: Discussionmentioning

confidence: 99%

Doubly Misdiagnosed: Exophiala Masquerading as Squamous Cell Carcinoma and Chromoblastomycosis

Guerra

Guffey

Russell

2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Deep cutaneous fungal infections (DCFI) can arise in the setting of skin trauma and immunosuppression. DCFI may be secondary to chromoblastomycosis, which is typically characterized by pseudoepitheliomatous hyperplasia histologically and can be mistaken for squamous cell carcinoma. In addition, "copper penny" spore-like pigmented yeast forms on Grocott's methenamine silver stain can suggest chromoblastomycosis, but this finding is not specific. By contrast, phaeohyphomycosis characteristically exhibits circumscribed pseudocyst or abscess on histopathology, and both yeast and hyphae can be seen. Our case reports a DCFI with pseudoepitheliomatous hyperplasia and "copper penny" yeast forms, ultimately diagnosed as phaeohyphomycosis after isolating Exophiala spinifera on fungal culture.

show abstract

Counterfeit Pennies: Distinguishing Chromoblastomycosis From Phaeohyphomycotic Infections

Cited by 6 publications

References 11 publications

Chromoblastomycosis Caused by Fonsecaea monophora Mimicking Lichen Planus

Chromoblastomycosis Caused by Fonsecaea monophora Mimicking Lichen Planus

Chromoblastomycosis successfully treated with the combination of itraconazole and 5-flucytosine

Doubly Misdiagnosed: Exophiala Masquerading as Squamous Cell Carcinoma and Chromoblastomycosis

Contact Info

Product

Resources

About