Council of Europe Black Sea Area Project: International Cooperation for the Development of Activities Related to Donation and Transplantation of Organs in the Region

Arredondo, Estephan; López-Fraga, Marta; Chatzixiros, Efstratios; Senemaud, Béatrice; Brezovský, P; Carella, Claudia; Ballesté, Chloë; Mehmet, A Aydin; Tomadze, Gia; Codreanu, Igor; Sarkissian, Ashot; Simeonova, M; Nikonenko, A. S.; Zota, Victor; Gómez, María Paula; Manyalich, M.; Bolotinha, Catarina; França, Ana Paula Figueiredo de Montalvão; Costa, Alessandro Nanni; Ott, M-O; Buchheit, K-H

doi:10.1016/j.transproceed.2017.12.043

Cited by 102 publications

(9 citation statements)

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“…The resulting number of unique entries identified in samples was 33. Interactions (such as co-occurrence and co-exclusion) among these were identified using CoNet app ( Faust and Raes, 2016 ) in Cytoscape ( Shannon et al, 2003 ) using the following ensemble of methods: Pearson correlation ( Pearson, 1895 ), Spearman correlation ( Sedgwick, 2014 ), mutual information ( Cover and Thomas, 2012 ), Bray-Curtis dissimilarity ( Bray and Curtis, 1957 ), and Kullback-Leibler divergence ( Kullback and Leibler, 1951 ). Statistical significance of each pair was tested using the row-shuffle randomization option and interactions that scored at the top and bottom 5% of 1000 bootstraps were reported.…”

Section: Methodsmentioning

confidence: 99%

“…Each method used for the identification of co-occurrence/co-exclusion networks has strengths and weaknesses in identifying particular patterns. CoNet ( Faust and Raes, 2016 ), uses an ensemble approach that combines results from a collection of algorithms ( Pearson, 1895 ; Kullback and Leibler, 1951 ; Bray and Curtis, 1957 ; Cover and Thomas, 2012 ; Sedgwick, 2014 ) using presence/absence and relative abundance data to identify statistically significant interactions. Interaction networks provide another methodology to examine the community structure of the microbiome of mosquitoes.…”

Section: Introductionmentioning

confidence: 99%

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Microbiome Interaction Networks and Community Structure From Laboratory-Reared and Field-Collected Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus Mosquito Vectors

et al. 2018

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Microbial interactions are an underappreciated force in shaping insect microbiome communities. Although pairwise patterns of symbiont interactions have been identified, we have a poor understanding regarding the scale and the nature of co-occurrence and co-exclusion interactions within the microbiome. To characterize these patterns in mosquitoes, we sequenced the bacterial microbiome of Aedes aegypti, Ae. albopictus, and Culex quinquefasciatus caught in the field or reared in the laboratory and used these data to generate interaction networks. For collections, we used traps that attracted host-seeking or ovipositing female mosquitoes to determine how physiological state affects the microbiome under field conditions. Interestingly, we saw few differences in species richness or microbiome community structure in mosquitoes caught in either trap. Co-occurrence and co-exclusion analysis identified 116 pairwise interactions substantially increasing the list of bacterial interactions observed in mosquitoes. Networks generated from the microbiome of Ae. aegypti often included highly interconnected hub bacteria. There were several instances where co-occurring bacteria co-excluded a third taxa, suggesting the existence of tripartite relationships. Several associations were observed in multiple species or in field and laboratory-reared mosquitoes indicating these associations are robust and not influenced by environmental or host factors. To demonstrate that microbial interactions can influence colonization of the host, we administered symbionts to Ae. aegypti larvae that either possessed or lacked their resident microbiota. We found that the presence of resident microbiota can inhibit colonization of particular bacterial taxa. Our results highlight that microbial interactions in mosquitoes are complex and influence microbiome composition.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbiome Interaction Networks and Community Structure From Laboratory-Reared and Field-Collected Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus Mosquito Vectors

et al. 2018

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“…The factors which generate a low level of organ donation and procurement in Romania are: the increased level of viral infections, the poor medical education and the faulty information-delivery process, the absence of organ procurement centers and of tissue banks and the need to obtain the consent of the family for organ donation [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Organ transplantation in Romania: challenges and perspectives

Bacusca

Tinică

Enache

et al. 2023

Medicine and Pharmacy Reports

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Introduction. The interest in the field of organ transplantation and the first attempts at making experimental transplant interventions in Romania date from the very beginning of the 20th century. Nevertheless, the evolution of the donating activity and of organ transplantation in Romania has been confronted with a certain inconsistency and a lack of resources necessary to the development of the system. Method. The aim of this study is to analyze the dynamics of the transplantation activity in Romania between 2000 and 2020. The study was accomplished through the analysis of available data corresponding to the above-mentioned period, which were published in the database of the National Transplant Agency, Eurostat and the Global Observatory on Donation and Transplantation. The data were processed using the MedCalc Statistical Software, version 14.8.1 (MedCalc Software bvba, Ostend, Belgium; http://www.medcalc.org; 2014). Results. The activity of donation and organ transplantation in Romania has been maintained at a low level, with a rate of 3.44 donators pmp and a transplantation rate of 12.55 pmp, as reported for the year 2020. Romania remains at a transplantation rate of under 6.6 pmp, despite the considerable increase in the number of patients on the waiting lists, a fact which describes the picture of a relatively weak system, incapable of providing surgical interventions to cover the minimum needs that emerge within a calendar year. Conclusions. Our study points to the fact that the transplantation system in Romania is confronted with a major deadlock. Romania holds the last-but-one place in the ranking of countries in the European Union on transplant activity. The major impediment is the donation rate, which continues to be way below the European average, in a society where the awareness of the necessity to donate is very low, bureaucracy is cumbersome and there is a high degree of mistrust in the medical system, where the equipment is lacking and the infrastructure is incapable of providing services adapted to the modern standards.

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“…With a donation rate of 3.44 donors per million inhabitants, Romania is ranked 42 nd out of 82 states providing Global Observatory on Donation and Transplantation data on donation and transplantation activity in 2020 [ 6 ]. Despite significant improvements in Romania’s healthcare system since joining the European Union (EU), including some in the transplantation system, the actual donor number has paradoxically fallen since 2014, contrary to the European trend [ 4 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Organ Procurement, Donation, and Transplant Awareness in an Urban Eastern European Region: A General Population Survey

Bacusca¹,

Burlacu²,

Tinică³

et al. 2022

Ann Transplant

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Background Despite significant improvements in Romania’s transplantation system, actual donor numbers have paradoxically fallen, contrary to the European trend. With a donation rate of 3.44 donors per million inhabitants, Romania ranks near the bottom of European countries. This study aimed to identify several predictors of a positive attitude toward organ donation in the Romanian population that could aid in reshaping public policies to improve donation and transplantation rates. Material/Methods The study included a representative Iasi population. Data were collected by means of a questionnaire focused on revealing attitudes toward organ donation, importance of consent, willingness to donate a family member’s organs, and role of medical staff in the donation decision. A perception score was calculated as a methodological approach to validate attitudes toward organ donation. Results Of all respondents, 55% agreed to donate their organs if declared brain-dead, while 20% opposed this idea; 72.7% considered consent necessary; 70% believed that consent must belong to the family when it comes to brain-dead organ donors; and 44.5% supported the idea of financial compensation. Higher monthly income was correlated with a positive attitude toward organ donation. Conclusions Even though the study population had a positive attitude toward organ donation, the willingness to donate was lower than in other European countries and did not translate into actual donations. The necessity of informed consent, lack of knowledge on the topic, bureaucratic aspects, and openness to financial compensation could explain the current situation of the Romanian transplantation system.

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Council of Europe Black Sea Area Project: International Cooperation for the Development of Activities Related to Donation and Transplantation of Organs in the Region

Cited by 102 publications

References 4 publications

Microbiome Interaction Networks and Community Structure From Laboratory-Reared and Field-Collected Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus Mosquito Vectors

Microbiome Interaction Networks and Community Structure From Laboratory-Reared and Field-Collected Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus Mosquito Vectors

Organ transplantation in Romania: challenges and perspectives

Organ Procurement, Donation, and Transplant Awareness in an Urban Eastern European Region: A General Population Survey

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