Coumestrol and its metabolite in mares' plasma after ingestion of phytoestrogen-rich plants: Potent endocrine disruptors inducing infertility

Ferreira‐Dias, Graça; Botelho, M.; Zagrajczuk, A.; Rebordão, Maria Rosa; Galvão, António; Pinto‐Bravo, Pedro; Piotrowska-Tomala, K.K.; Szóstek, A.Z.; Wiczkowski, Wiesław; Piskuła, Mariusz K.; Fradinho, Maria João; Skarzynski, Dariusz J.

doi:10.1016/j.theriogenology.2013.06.002

Cited by 22 publications

(28 citation statements)

References 37 publications

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“…In three controlled experiments conducted in Portugal and Poland, groups of mares were grazed on or fed coumestrol-containing diets. Coumestrol and 'methoxy-coumestrol' (possibly 4'-methoxy-coumestrol [151]) increased after ingestion of oestrogenic plant material [29,151]. In Experiment I, coumestans in a legume-grass pasture declined during winter but were always present in the plasma of the grazing mares (Table 4) .…”

Section: Horsesmentioning

confidence: 88%

“…Some New Zealand studies with lucerne found coumestrol was the more dominant compound [26][27][28]. In their analysis of 5 coumestan-containing pastures and 7 coumestan-containing fodders/concentrates (lucerne -and some annual medics and clover, unnamed), Ferriera-Dias et al (2013) [29] consistently found a much greater ratio of methoxy-coumestrol:coumestrol (mean for pasture 24.3, range 3.8-44.1; mean for fodder 3.6, range 2.9-6.8).…”

Section: Phytoestrogenic Compoundsmentioning

confidence: 99%

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Fertility of Herbivores Consuming Phytoestrogen-containing Medicago and Trifolium Species

Reed¹

2016

Agriculture

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Despite their unrivalled value in livestock systems, certain temperate, pasture, legume species and varieties may contain phytoestrogens which can lower flock/herd fertility. Such compounds, whose chemical structure and biological activity resembles that of estradiol-17α, include the isoflavones that have caused devastating effects (some of them permanent) on the fertility of many Australian sheep flocks. While the persistence of old 'oestrogenic' ecotypes of subterranean clover (Trifolium subterraneum) in pasture remains a risk, genetic improvement has been most effective in lowering isoflavone production in Trifolium species; infertility due to 'clover disease' has been greatly reduced. Coumestans, which can be produced in Medicago species responding to stress, remain a potential risk in cultivars susceptible to, for example, foliar diseases. In the field, coumestrol is often not detected in healthy vegetative Medicago species. Wide variation in its concentration is influenced by environmental factors and stage of growth. Biotic stress is the most studied environmental factor and, in lucerne/alfalfa (Medicago sativa), it is the major determinant of oestrogenicity. Concentrations up to 90 mg coumestrol/kg (all concentrations expressed as DM) have been recorded for lucerne damaged by aphids and up to 600 mg/kg for lucerne stressed by foliar disease(s). Other significant coumestans, e.g., 4'-methoxy-coumestrol, are usually present at the same time. Concentrations exceeding 2000 mg coumestrol/kg have been recorded in diseased, annual species of Medicago. Oestrogenicity of some Medicago species is also influenced by maturity and senescence. Studies in Israel, North America, Europe, New Zealand and Australia have confirmed that coumestans in lucerne, represent an acute or sub-acute loss of reproductive efficiency in herbivores, e.g., sheep, cattle, and possibly horses. When sufficiently exposed peri-conception, coumestrol, sometimes present in lucerne, be it as pasture, hay, silage, pellets, meal, and sprouts, is associated with what can be an insidious, asymptomatic, infertility syndrome. Most livestock research with oestrogenic lucerne has been conducted with sheep. Ewes may be at risk when the coumestrol concentration in their diet exceeds 25 mg/kg. In studies where lambing was compared for lucerne and a phytoestrogen-free treatment, the mean decrease in lambs born/ewe was 13%; ewes on lucerne, exhibited a lower frequency of multiple births.

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Section: Horsesmentioning

confidence: 88%

Section: Phytoestrogenic Compoundsmentioning

confidence: 99%

Fertility of Herbivores Consuming Phytoestrogen-containing Medicago and Trifolium Species

Reed¹

2016

Agriculture

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“…The main component of the essential oil is anethole. They may compete with 17-β estradiol and influence the estrous cycle (Ferreira-Dias 2013). Besides efficacious digestion, the estrogenic agents of SA can also contribute to better milk secretion (Albert-Puleo 1980) and can be used as a galactagogue (Tipu et al 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Phytoestrogens can weakly bind to estrogen receptors, thereby acting as estrogen. They may compete with 17-β estradiol and influence the estrous cycle (Ferreira-Dias 2013). With daidzein (a kind of phytoestrogen) administration, prolactin (PRL) levels of sow serum were strikingly enhanced;…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary star anise (Illicium verum Hook f) supplementation during gestation and lactation on the performance of lactating multiparous sows and nursing piglets

Wang

Yang

et al. 2014

Animal Science Journal

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Thirty-two sows were allocated to four treatments to evaluate the effect of dietary star anise (SA) supplementation during gestation and lactation on the lactational performance of sows. At 85 days of gestation, sows were randomly allotted to one of two diets supplemented with 0.5% SA or basal diet. After farrowing, sows were further allotted to one of two lactation diets supplemented with 0.5% SA or basal diet. On a weekly basis, body weight (BW) of sows and piglets was measured. Blood and milk samples were obtained from the sows and piglets. Number of days from weaning to estrus, milk yield and feed intake were also recorded. Weight gain of piglets from sows fed the SA-supplemented diet during lactation was greater between days 7 and 14, days 14 and 21 and the overall experimental period compared with control groups. Supplementation of SA during lactation improved weaning weight of piglets, milk yield and average daily feed intake (ADFI) of sows. The SA diet increased concentrations of insulin-like growth factor-1 (IGF-1) in ordinary milk and prolactin (PRL) in serum of sows. In conclusion, this study has indicated the beneficial effects of dietary SA addition in improving the lactation performance of sows.

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“…In addition to the traditional toxins (i.e., mycotoxin, plants) known to cause reproductive disorders (infertility or abortion), steroid disruptors have been a great concern for both animal and human health (88, 89). …”

Section: Reproductive Medicinementioning

confidence: 99%

Grand Challenge Animal Reproduction-Theriogenology: From the Bench to Application to Animal Production and Reproductive Medicine

Tibary

2017

Front. Vet. Sci.

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Coumestrol and its metabolite in mares' plasma after ingestion of phytoestrogen-rich plants: Potent endocrine disruptors inducing infertility

Cited by 22 publications

References 37 publications

Fertility of Herbivores Consuming Phytoestrogen-containing Medicago and Trifolium Species

Fertility of Herbivores Consuming Phytoestrogen-containing Medicago and Trifolium Species

Effects of dietary star anise (Illicium verum Hook f) supplementation during gestation and lactation on the performance of lactating multiparous sows and nursing piglets

Grand Challenge Animal Reproduction-Theriogenology: From the Bench to Application to Animal Production and Reproductive Medicine

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