Coumarins of the roots ofPhlojodicarpus sibiricus

Antonova, O. K.; Shemeryankin, B. V.

doi:10.1007/bf00574388

Cited by 3 publications

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“…Finally, 35 coumarins were detected in the roots and herb of P. sibiricus , and only seven of them were previously discovered in this plant species. These were umbelliferone ( 1 ) [8], khellactone ( 3 ), khellactone 4′- O -methyl ester ( 4 ), hyuganin D ( 12 ) [9], visnadin ( 13 ) [6], dihydrosamidin ( 15 ) [7] and suksdorfin ( 16 ) [9]. Twenty-eight coumarins (compounds 2 , 5 – 11 , 14 , 17 – 32 , 39 – 41 ) were newly discovered components of P. sibiricus .…”

Section: Resultsmentioning

confidence: 99%

“…The scientific interest in species of Phlojodicarpus is due to the presence of coumarins, marker components of the Apiaceae family [5]. Three Phlojodicarpus species (excluding P. popovii ) were chemically investigated as sources of coumarins; among them, 31 compounds of the simple group, furocoumarins and pyranocoumarins, were isolated [6,7,8,9,10,11,12,13,14,15] (Table S1). Insufficient attention has been given however to the other groups of phytocomponents.…”

Section: Introductionmentioning

confidence: 99%

“…The known literature data on the chemical composition of the roots of P. sibiricus refers only to plants growing in the Far East, and mentions visnadine [6], dihydrosamidine [7], umbelliferone and scopoletin [8]. Suksdorfin, khellactone 4′- O -methyl ester and khellactone 3′- O -acetyl-4′- O -(2-methylbutyroyl) ester [9] were discovered among the components of the P. sibiricus herb from the Zabaykal’sky Krai; plants from Mongolia were found to accumulate phlojodicarpin, isophlojodicarpin [10], umbelliferone 7- O -(6′-apiofuranosyl)-glucopyranoside (6′-apiosylskimmin), 8-(2′,3′-dihydroxy-3′-methylbutyl)oxycoumarin 7- O -glucopyranoside and diosmetin 7- O -glucopyranoside [11].…”

Section: Introductionmentioning

confidence: 99%

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Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

et al. 2019

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With obesity, the consumption of phenolic-enriched food additives as a part of traditional nutrition avoids the negative implications of eating high-calorie products. This study investigated the new herbal food additive, Phlojodicarpus sibiricus roots and herb, ubiquitously used in Siberia as a spice. Chromatographic techniques such as HPLC-DAD-ESI-QQQ-MS/MS and microcolumn HPLC-UV were the basic instruments for component profiling and quantification, and antiobesity potential was investigated using a differentiated 3T3-L1 adipocytes assay. We found that the roots and herb of P. sibiricus were high-coumarin-containing additives inhibiting triacylglycerol accumulation in 3T3-L1 preadipocytes. Forty-one phenolics were detected in P. sibiricus extracts, and 35 were coumarins, including 27 khellactone derivatives present as esters and glucosides. Total coumarin content varied from 36.16 mg/g of herb to 98.24 mg/g of roots, and from 0.32 mg/mL to 52.91 mg/mL in P. sibiricus preparations. Moreover, Siberian populations of P. sibiricus were characterised by a different HPLC-based coumarin profile. The most pronounced inhibiting effect on triacylglycerol accumulation in 3T3-L1 preadipocytes was shown for dihydrosamidin (khellactone 3′-O-isovaleroyl-4′-O-acetyl ester), which was more active than other khellactone esters and glucosides. The results demonstrated that if used as a food additive Phlojodicarpus sibiricus could be a source of bioactive coumarins of the khellactone group with high antiobesity potential.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

et al. 2019

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“…Koso-Pol., a rare and valuable medicinal plant found in Russia and Mongolia [ 17 ]. According to various authors, P. sibiricus contains umbelliferon [ 18 ], khellactone, 4′- O -methyl ether of khellactone, hyuganin D, suxdorphin [ 19 ], visnadine [ 20 ], and dihydrosamidine [ 21 ]. Olennikov and coauthors, using high-performance liquid chromatography with a diode array detector and a triple quadrupole detector with ionizing electrospray, determined the composition of coumarins, flavonoids, and phenylpropanoids in the roots of P. sibiricus .…”

Section: Introductionmentioning

confidence: 99%

The Different Composition of Coumarins and Antibacterial Activity of Phlojodicarpus sibiricus and Phlojodicarpus villosus Root Extracts

Khandy,

Grigorchuk,

Sofronova

et al. 2024

Plants

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Phlojodicarpus sibiricus, a valuable endangered medicinal plant, is a source of angular pyranocoumarins used in pharmacology. Due to limited resource availability, other pyranocoumarin sources are needed. In the present research, the chemical composition of a closely related species, Phlojodicarpus villosus, was studied, along with P. sibiricus. High-performance liquid chromatography and mass-spectrometric analyses, followed by antibacterial activity studies of root extracts from both species, were performed. P. sibiricus and P. villosus differed significantly in coumarin composition. Pyranocoumarins predominated in P. sibiricus, while furanocoumarins predominated in P. villosus. Osthenol, the precursor of angular pyrano- and furanocoumarins, was detected in both P. sibiricus and P. villosus. Angular forms of coumarins were detected in both species according to the mass-spectrometric behavior of the reference. Thus, P. villosus cannot be an additional source of pyranocoumarins because their content in the plant is critically low. At the same time, the plant contained large amounts of hydroxycoumarins and furanocoumarins. The extracts exhibited moderate antibacterial activity against five standard strains. The P. villosus extract additionally suppressed the growth of the Gram-negative bacterium E. coli. Thus, both Phlojodicarpus species are promising for further investigation in the field of pharmaceuticals as producers of different coumarins.

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Growth and Biosynthetic Characteristics of Phlojodicarpus sibiricus Cell Suspension Cultures

Ханды

Кочкин

Tomilova

et al. 2021

Russ J Plant Physiol

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Coumarins of the roots ofPhlojodicarpus sibiricus

Cited by 3 publications

References 0 publications

Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae): HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin

The Different Composition of Coumarins and Antibacterial Activity of Phlojodicarpus sibiricus and Phlojodicarpus villosus Root Extracts

Growth and Biosynthetic Characteristics of Phlojodicarpus sibiricus Cell Suspension Cultures

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