Coumarins of the roots of Ferula foetidissima

Abstract

Continuing a study of species of Ferula of the subgenus Narthex (Falc.) Drude, we have investigated the coumarins of the roots of Ferula foetidissima Regel et Schmalh. collected in the type site of this plant (TadzhSSR, Zeravshan range, R. Iskanderdar'ya) in August, 1972. From an extract obtained by the treatment of the comminuted roots with carbon tetrachloride, by chromatography on a column of alumina (activity grade II) we have isolated two coumarins, with Rf 0.85 (I) and 0.54 (II) [TLC, Silufol, chloroformethanol (97 : 3) system]. The yields of these substances on the weight of the dry raw material were 0.16 and 0.20 %, respectively.On the basis of their IR and NMR spectra and the absence of depressions of the melting points of mixtures with the appropriate authentic samples, compound (I) having the composition Cz4H2804 (M + 380), mp 141-141.5"C (ethyl acetate-petroleum ether) and compound (lI), having the composition C24H3004 (M + 382), mp 137-138°C (diethyl ether-petroleum ether) were identified as conferone [1] and conferol [2], respectively.Thus, the isolation from F. foetidissima of conferone and conferol, which have been obtained previously from Ferula conocaula Korov. [1, 2] indicates the taxonomic closeness of these species of the subgenus Narthex (Falc.) Drude. LITERATURE CITED1.

Terpenoid Coumarins of the Genus Ferula

“…Isos amarkandin (89) is the stereois omer of samarcandin (86) having the opposite configuration at C-3, while nevskin (91) being the C-3 epimer of 89. 7 7 Microlobin (110) is the hydroxy derivative of the known coumarin kamolone (108) to which it is chemically related. 7 7 Microlobin (110) is the hydroxy derivative of the known coumarin kamolone (108) to which it is chemically related.…”