Coumarins of Ferulago turcomanica

Serkerov, S. V.; Kagramanov, A. A.; Abbasov, R. M.

doi:10.1007/bf00570197

Cited by 7 publications

(3 citation statements)

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“…The comparison of our results with the literature showed that prantschimgin and oxypeucedanin are presented in other species of the genus. Oxypeucedanin was previously reported from Ferulago bernardi, Ferulago brachyloba, Ferulago capillaris, Ferulago granatensis, Ferulago meoides and Ferulago turcomaniaca (Anderianova et al 1975;Depascual et al 1979;Jiménez et al 2000;Buckingham 2005;Khalighi-Sigaroodi et al 2006 F. bernardi (Serkerov et al 1976;Depascual et al 1979;Doganca et al 1992;Jiménez et al 2000;Khalighi-Sigaroodi et al 2006). Thus, these compounds could be regarded as characteristic compounds and chemotaxonomic markers in the Ferulago genus.…”

Section: Resultsmentioning

confidence: 88%

The investigation on phytochemicals from Ferulago angulata (Schlecht) Boiss, indigenous to central parts of Iran

Razavi

Ravansalar

Mirinejad³

2015

Natural Product Research

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Ferulago angulata (Schlecht) Boiss (Apiaceae) is a perennial herb distributed in the central parts of Iran. In this work, the essential oil of Ferulago angulata aerial parts collected from the central parts of Iran was obtained by using hydrodistillation analysed by GC and GC-MS. Air-dried and powdered plant roots were extracted with n-hexane, dichloromethane and methanol, respectively, using a Soxhlet apparatus. The n-hexane extract was subjected to preparative thin-layer chromatography using chloroform-acetone (95:5) as solvent system to yield two linear furanocoumarins, prantschimgin and oxypeucedanin. The structure of theisolated compounds was elucidated by using spectroscopic data such as (1)H NMR, (13)C NMR, UV and IR. The results of GC-MS analyses showed that γ-terpinolene (11.97%), α-pinene (10.00%), sabinene (6.89%), linalool (5.56%) and cis-ocimene (4.41%) were the main components among 51 constituents characterised in the oil. The oil exhibits considerable phytotoxic activity.

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Section: Resultsmentioning

confidence: 88%

The investigation on phytochemicals from Ferulago angulata (Schlecht) Boiss, indigenous to central parts of Iran

Razavi

Ravansalar

Mirinejad³

2015

Natural Product Research

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“…The chemical investigation of some Ferulago species have shown coumarins, sesquiterpenes and aromatic compounds [5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Volatile Constituents of the Aerial parts ofFerulago subvelutinaRech. f.,Ferulago stellataBoiss., Leaves and Flowers ofPrangos ferulacea(L.) Lindle. and Leaves ofFerula ovina(Boiss.) Boiss. Four Umbelliferae Herbs from Iran

Masoudi

Eghbali

Abadi

2016

Journal of Essential Oil Bearing Plants

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“…(Ognyanov & Bocheva, 1969), Ferulago turcomanica Schisch. (Andrianova et al, 1975;Serkerov et al, 1976), Ferulago sylvatica Rchb. (Sklyar et al, 1982), Ferulago granatensis Boiss.…”

Section: Introductionunclassified

Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation ofFerulago carduchorumin rats

Golfakhrabadi¹,

Abdollahi²,

Ardakani³

et al. 2014

Pharmaceutical Biology

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Context: Ferulago carduchorum Boiss. & Hausskn. (Apiaceae) is known as Chavil in Persian which grows in west of Iran. Local people add Chavil to dairy and oil ghee as a natural preservative to extend the expiration date. Objective: The goal of this survey is the safety evaluation of the total extract of F. carduchorum in rats by determining both oral acute and subchronic toxicities; furthermore, the anticoagulant activity of isolated coumarins was evaluated. Materials and methods: The aerial parts of F. carduchorum were extracted by the percolation method. The anticoagulant activity of isolated coumarins was evaluated and the total extract was used to investigate acute and subchronic toxicity in rats. In the subchronic toxicity model, doses of 250, 500, and 1000 mg/kg of the extract were administered to treated groups for 30 consecutive days by gavage. Results: According to the results of acute toxicity, the LD 50 of Chavil extract was more than 2000 mg/kg. The subchronic study showed no significant difference (p40.05) between the groups treated with extract and control groups in hematological (erythrocyte, total and differential leukocyte, hematocrit, hemoglobin, platelet count) and biochemical parameter (glucose, albumin, cholesterol, triglycerides, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) evaluations. The isolated coumarins (suberosin and suberenol) prolonged the prothrombin time (PT) at doses of 3 and 6 mg/kg compared with control (p50.05). The longest PT was for suberosin at 6 mg/kg (17.4 s). Conclusion: In conclusion, oral administration of the Chavil extract did not cause either acute or subchronic toxicities although the coumarins showed anticoagulant effect in rats.

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Coumarins of Ferulago turcomanica

Abstract: F r o m the roots of Ferulago t u r c o m a n i c a. S c h i s c h k. c o l l e c t e d i n t h e T u r k m e n SSR, by chromatography on a column of alumina, we have isolated five crystalline substances of coumarin nature.

Cited by 7 publications

References 0 publications

The investigation on phytochemicals from Ferulago angulata (Schlecht) Boiss, indigenous to central parts of Iran

The investigation on phytochemicals from Ferulago angulata (Schlecht) Boiss, indigenous to central parts of Iran

Volatile Constituents of the Aerial parts ofFerulago subvelutinaRech. f.,Ferulago stellataBoiss., Leaves and Flowers ofPrangos ferulacea(L.) Lindle. and Leaves ofFerula ovina(Boiss.) Boiss. Four Umbelliferae Herbs from Iran

Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation ofFerulago carduchorumin rats

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