Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways

Rostom, Batoul; Karaky, Racha; Kassab, Issam; Veitía, Maité Sylla-Iyarreta

doi:10.1016/j.ejphar.2022.174867

Cited by 35 publications

(25 citation statements)

References 189 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its derivatives have found broad applications such as fluorescent probes [1][2][3][4], food additives [5][6][7], in polymer chemistry [8][9][10][11], and so on. Numerous representatives have displayed variable bioactivity profiles [12][13][14][15][16][17][18], including anticancer [19][20][21][22][23][24], anti inflammatory [25][26][27], anti-tuberculosis [28,29], antimicrobial [30], and many others. Several drugs with coumarin skeleton are available on the market, such as immunosuppressant scoparone, anti-inflammatory drug 8-methoxypsoralen, vasodilator carbochromen, anticoagulants warfarin and phenprocoumon, antifungal agent osthole, anti-HIV preparatus calanolide, anticancer drug flavopiridol, antibiotics novobiocin and clorobiocin, and so on; some are shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

4-Methyl-7-((2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethyl)thio)-coumarin

Kurteva

Rusew

Shivachev

2022

Molbank

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

4-Methyl-7-((2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethyl)thio)-coumarin

Kurteva

Rusew

Shivachev

2022

Molbank

View full text Add to dashboard Cite

show abstract

“…Coumarins and their derivatives have been found to be effective against myriad clinically important molecular targets, exerting their pharmacological actions such as anti-neoplastic, antibacterial, anti-fungal, and anti-inflammatory activities to name a few. − Recently, the cytotoxicity profiles and the DNA binding activities of the (DHFC) derivatives have been discovered, which may indicate their potential candidature for future clinical usages. However, the efficiency of a drug depends on their selective localization to the target tissue/organ in therapeutic concentration, which will maximize their molecular action as well as will minimize the chance for off-target binding and related side effects …”

Section: Resultsmentioning

confidence: 99%

Effective Synthesis and Biological Evaluation of Functionalized 2,3-Dihydrofuro[3,2-c]coumarins via an Imidazole-Catalyzed Green Multicomponent Approach

et al. 2022

View full text Add to dashboard Cite

For the first time, an eco-friendly and efficient onepot green multicomponent approach has been described to synthesize functionalized trans-2, 3-dihydrofuro[3,2-c]coumarins (DHFCs). In this synthesis, imidazole and water were used as the catalyst and solvent, respectively, under mild conditions. Applications of the developed catalytic process in a water medium revealed the outstanding activity, productivity, and broad functional group tolerance, affording a series of newly designed DHFC and derivatives in excellent yields (72−98%). Moreover, the human serum albumin (HSA) binding ability of the synthesized DHFC derivatives has been uncovered through the detailed in silico and in vitro-based structure-activity analysis. The ability to bind HSA, the most abundant serum protein, in the low micromolar ranges unequivocally reflects the suitable absorption, distribution, metabolism, and elimination profile of the synthesized compounds, which may further be envisaged for their therapeutic usage endeavors.

show abstract

“…Coumarins bear a 2H-chromen-2-one (2H-1-benzopyran-2-one or benzo-alpha-pyrone) ring. 384 Bergamottin, a natural product found in bergamot, exhibits a structure similar to that of furanocoumarin. Zhou et al have reported its inhibitory activity against SARS-CoV-2 both in vitro and in vivo.…”

Section: Structures Of Small Molecule Drugs For Covid-19 Therapymentioning

confidence: 99%

Small molecules in the treatment of COVID-19

Lei

Chen

Jin

et al. 2022

Sig Transduct Target Ther

View full text Add to dashboard Cite

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to societies and economies. Until now, effective therapeutics against COVID-19 are in high demand. Along with our improved understanding of the structure, function, and pathogenic process of SARS-CoV-2, many small molecules with potential anti-COVID-19 effects have been developed. So far, several antiviral strategies were explored. Besides directly inhibition of viral proteins such as RdRp and Mpro, interference of host enzymes including ACE2 and proteases, and blocking relevant immunoregulatory pathways represented by JAK/STAT, BTK, NF-κB, and NLRP3 pathways, are regarded feasible in drug development. The development of small molecules to treat COVID-19 has been achieved by several strategies, including computer-aided lead compound design and screening, natural product discovery, drug repurposing, and combination therapy. Several small molecules representative by remdesivir and paxlovid have been proved or authorized emergency use in many countries. And many candidates have entered clinical-trial stage. Nevertheless, due to the epidemiological features and variability issues of SARS-CoV-2, it is necessary to continue exploring novel strategies against COVID-19. This review discusses the current findings in the development of small molecules for COVID-19 treatment. Moreover, their detailed mechanism of action, chemical structures, and preclinical and clinical efficacies are discussed.

show abstract

Coumarins derivatives and inflammation: Review of their effects on the inflammatory signaling pathways

Cited by 35 publications

References 189 publications

4-Methyl-7-((2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethyl)thio)-coumarin

4-Methyl-7-((2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethyl)thio)-coumarin

Effective Synthesis and Biological Evaluation of Functionalized 2,3-Dihydrofuro[3,2-c]coumarins via an Imidazole-Catalyzed Green Multicomponent Approach

Small molecules in the treatment of COVID-19

Contact Info

Product

Resources

About