Coumarins as cholinesterase inhibitors: A review

Souza, de; Mn, Rennã; Jd, Figueroa-Villar

doi:10.1016/j.cbi.2016.05.001

Cited by 137 publications

(88 citation statements)

References 73 publications

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“…The inhibition of this enzyme could be a possible approach to delay neurodegenerative disease progression, but the use of this kind of therapeutic agents may cause several side effects. For all these reasons, several natural products which can be used as AChE inhibitors, but with fewer side effects, have replaced some of these drugs [28]. In order to verify their ability to inhibit AChE and, thus, to improve these neurodegenerative disorders, Calabrian and Chinese Goji extracts were tested.…”

Section: Discussionmentioning

confidence: 99%

Calabrian Goji vs. Chinese Goji: A Comparative Study on Biological Properties

Ruffo

Parisi

Amone

et al. 2017

Foods

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Lycium barbarum (Goji) fruits are mainly cultivated in northwestern China and are well known for their beneficial and healthy effects. In this work, the biological and functional properties of Calabrian Goji extract, obtained from Goji berries cultivated in the Sibari Plain (in the Italian region of Calabria), were demonstrated. In order to evaluate the use of this extract as a food supplement for cognitive and mental disorders, the quantification of Carotenoids as Zeaxanthin equivalents was made. The antioxidant activity was investigated by evaluating the scavenging properties against 2,2′-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals and by performing the ORAC (Oxygen Radical Absorbance Capacity) assay. The inhibition of lipid peroxidation was quantified by bleaching test and the ability to inhibit acetylcholinesterase enzyme and to scavenge nitric oxide radical was also evaluated. All the results were compared to those obtained from a Chinese Goji extract used as a reference. Based on the reported data, Calabrian Goji might be used as a food supplement with a possible application in cognitive disorders, mental impairments and other neurodegenerative diseases, due to its biological properties and the high levels of Carotenoids.

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Section: Discussionmentioning

confidence: 99%

Calabrian Goji vs. Chinese Goji: A Comparative Study on Biological Properties

Ruffo

Parisi

Amone

et al. 2017

Foods

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“…Phenylpropanoids, including lignins and coumarins, commonly exist in natural plants, and these compounds often have some interesting activities such as antiviral, antibacterial, anti-inflammatory and antitumor activities (de Souza et al, 2016;Hassan et al, 2016;Figueiredo et al, 2017).…”

Section: Phenylpropanoidsmentioning

confidence: 99%

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Peng

Liu

et al. 2019

Revista Brasileira de Farmacognosia

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a b s t r a c tToona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discussed in the corresponding parts of this paper, and perspectives for possible future studies of this plant are discussed. The main constituents of T. sinensis are terpenoids, phenylpropanoids and flavonoids, etc., and its pharmacological activities include anti-tumor effects, antioxidant activities, anti-diabetic effects and anti-inflammatory effects. Although a series of phytochemical and pharmacological researches of this plant have been conducted, the active constituents and action mechanism of these activities should be also further explored. Furthermore, the present review also indicates that T. sinensis has potentials to develop into drugs for treating various diseases with high efficacy and low toxicity, particularly in cancer, diabetes and inflammatory disorders. In conclusion, the paper provides a full-scale profile of the traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis, and also provides potential therapeutic uses and drug development prospects of this plant.

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“…On the other hand, coumarins are known to possess a selective inhibition towards BChE as verified by many researchers . Consistently, the genus Haplophyllum has been reported to contain a number of furano‐ and prenylated coumarins, i. e ., columbianetin, angelicin, umbelliprenin, 7‐isopentenyloxycoumarin, osthenol, ptilostol, ptilostin, etc .…”

Section: Resultsmentioning

confidence: 71%

Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts

Karahisar

Tuğay

Orhan

et al. 2019

Chemistry & Biodiversity

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In the current study, the ethanol extracts of flower, stem, and root parts of two endemic Turkish species, e. g., Haplophyllum sahinii O. Tugay & D. Ulukuş and H. vulcanicum Boiss. & Heldr., were screened against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) associated with Alzheimer's disease as well as tyrosinase (TYR) linked to Parkinson's disease using ELISA microplate assay at 200 μg/mL. Among the extracts, the highest inhibition was caused by the stem extract of H. sahinii against BChE (IC50=64.93±1.38 μg/mL). Consistently, all of the extracts were found to exert a selective inhibition towards BChE to some extent. It was only the root extract of H. vulcanicum that could inhibit AChE at low level (IC50=203.18±5.33 μg/mL). None of the extracts displayed an inhibition over 50 % against TYR. Metabolite profiling of the extracts was achieved by a highly hyphenated liquid chromatographic mass spectrometric technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS), which revealed the presence of furoquinoline (β‐fagarine, γ‐fagarine) and amide (tubasenicine, tubacetine) alkaloids; furano‐ (rutamarin), pyrano‐ (xanthyletine), and geranyloxy coumarins; phenylpropanoid (secoisolariciresinol), arylnaphthalene (mono‐O‐acetyldiphyllin apioside), and dibenzylbutyrolactone (kusunokinin, haplomyrfolin) lignans. Several important differences were observed between the extracts analyzed. β‐Fagarine was the major alkaloid in H. vulcanicum, whereas γ‐fagarine was present only in the roots of both Haplophyllum species; moreover, secoisolariciresinol and secoisolariciresinol dimethyl ether were the main lignans in the stems and flowers. This is the first study identifying ChE and TYR inhibitory effect and metabolic profiles of H. vulcanicum and H. sahinii.

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Coumarins as cholinesterase inhibitors: A review

Cited by 137 publications

References 73 publications

Calabrian Goji vs. Chinese Goji: A Comparative Study on Biological Properties

Calabrian Goji vs. Chinese Goji: A Comparative Study on Biological Properties

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts

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