Coumarin-rich Grifola frondosa ethanol extract alleviate lipid metabolism disorders and modulates intestinal flora compositions of high-fat diet rats

Wang, Chang'e; Zeng, Feng; Liu, Yilin; Pan, Yong; Xu, Jiaxin; Ge, Xiaodong; Zheng, Heping; Pang, Jie; Liu, Bin; Huang, Ying

doi:10.1016/j.jff.2021.104649

Cited by 16 publications

(6 citation statements)

References 67 publications

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“…Medicinal uses: Many studies confirmed a broad spectrum of biological activities of G. frondosa , including anti-aging [ 164 ], antiallergic [ 160 ], antidepressant [ 157 ], antidiabetic [ 156 , 233 ], anti-inflammatory [ 160 ], antimicrobial [ 159 , 165 ], antioxidant [ 164 , 166 ], antitumor [ 159 , 160 , 163 , 225 , 234 ], antiviral [ 235 ], hepatoprotective [ 166 ], hypoglycemic [ 161 ], hypolipidemic [ 236 ], immunomodulatory and immunostimulatory [ 158 , 237 ], nephroprotective [ 161 ], and neuroprotective [ 16 , 158 , 160 , 163 ].…”

Section: Resultsmentioning

confidence: 99%

Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices

Gafforov,

Rašeta,

Rapior

et al. 2023

JoF

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Interest in edible and medicinal macrofungi is millennial in terms of their uses in health and food products in Central Asia, while interest in inedible and medicinal macrofungi has grown in popularity in recent years. Edible and inedible medicinal basidiomycetes were collected during field surveys from different regions of Uzbekistan. The morphological characters and similarity assessment of rDNA-Internal Transcribed Spacer sequence data were used to measure diversity and habitat associations. A number of 17 species of medicinal macrofungi of ethnomycological and medicinal interest was found associated with 23 species of trees and shrubs belonging to 11 families and 14 genera. Polyporaceae and Hymenochaetaceae were represented by the highest number of species followed by Ganodermataceae, Fomitopsidaceae, Auriculariaceae, Cerrenaceae, Grifolaceae, Phanerochaetaceae, Laetiporaceae, Schizophyllaceae, and Stereaceae. The highest number of medicinal basidiomycete species was reported in the following host genera: Acer, Betula, Celtis, Crataegus, Juglans, Juniperus, Lonicera, Malus, Morus, Platanus, Populus, Prunus, Quercus, and Salix. An updated list of edible and inedible medicinal mushrooms identified in Uzbekistan, their morphological characteristics, and phylogenetic placement are given for the first time. Information is provided on their uses in traditional and modern medicine. Their bioactive compounds and extracts can be applied as medicines, as well as food and cosmetic ingredients.

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Section: Resultsmentioning

confidence: 99%

Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices

Gafforov,

Rašeta,

Rapior

et al. 2023

JoF

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“…In our previous studies, we found that Grifola frondosa extracts are also rich in flavonoids and polyphenols. These compositions are the fermentation substrates for probiotics, and they are the source of the antioxidant activity of Grifola frondosa [ 27 ]. Lactobacillus and Pediococcus acidilactici can use carbohydrates as an energy source to produce organic acids such as lactic acid [ 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Alistipes and Odoribacter were common beneficial intestinal bacteria in our previous studies. Wang et al and Pan et al found that the relative abundance of Alistipes positively correlated with SOD and GSH, and it was negatively correlated with TC, TG, AST, and ALT [ 27 , 29 ]. Odoribacter is short-chain fatty-acids-producing bacteria, and it is thought to promote blood lipid metabolism [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

“…Chen et al found that Grifola frondosa polysaccharides could inhibit liver lipid peroxidation in rats [ 26 ]. In our previous studies, we have found that 95% and 55% Grifola frondosa ethanol extract and Grifola frondosa heteropolysaccharide could improve glucose and lipid metabolism disorders by attenuating tissue inflammation, reducing the occurrence of liver lesions, and regulating the intestinal microbiota [ 27 , 28 , 29 ]. Therefore, Grifola frondosa has anti-inflammation and hepatoprotective abilities and improves the structure of the intestinal microbiota, so it shows potential for improving ALD.…”

Section: Introductionmentioning

confidence: 99%

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Probiotics-Fermented Grifola frondosa Total Active Components: Better Antioxidation and Microflora Regulation for Alleviating Alcoholic Liver Damage in Mice

He¹,

Zhu

Jiang

et al. 2023

IJMS

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Alcoholic liver damage is caused by long-term drinking, and it further develops into alcoholic liver diseases. In this study, we prepared a probiotic fermentation product of Grifola frondosa total active components (PFGF) by fermentation with Lactobacillus acidophilus, Lactobacillus rhamnosus, and Pediococcus acidilactici. After fermentation, the total sugar and protein content in the PFGF significantly decreased, while the lactic acid level and antioxidant activity of the PFGF increased. Afterward, we investigated the alleviating effect of PFGF on alcoholic liver injury in alcohol-fed mice. The results showed that the PFGF intervention reduced the necrosis of the liver cells, attenuated the inflammation of the liver and intestines, restored the liver function, increased the antioxidant factors of the liver, and maintained the cecum tissue barrier. Additionally, the results of the 16S rRNA sequencing analysis indicated that the PFGF intervention increased the relative abundance of beneficial bacteria, such as Lactobacillus, Ruminococcaceae, Parabacteroids, Parasutterella, and Alistipes, to attenuate intestinal inflammation. These results demonstrate that PFGF can potentially alleviate alcoholic liver damage by restoring the intestinal barrier and regulating the intestinal microflora.

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“…Wang et al reported that β-glucan in GFP could significantly inhibit the cytopathic effect (CPE) induced by herpes simplex virus type I ( 9 ). In addition, GFP had been shown to have hypoglycemic ( 10 ), anti-hyperlipidemia ( 11 ), and anti-radiation effects ( 12 ), as well as protecting the gastric mucosa and liver ( 13 ). Therefore, GFP has often been referred to as a biological response modifier (BRM) ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Structural properties and anti-inflammatory activity of purified polysaccharides from Hen-of-the-woods mushrooms (Grifola frondosa)

Liu

Chen²,

Liu³

et al. 2023

Front. Nutr.

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Grifola frondosa is an edible medicinal mushroom that has been proven to have a variety of health benefits. The main active ingredients of this mushroom are polysaccharides. In this study, ultrasonic-assisted extraction was used to obtain crude Grifola frondosa polysaccharides (GFPs). Then, purified GFP was obtained after purification. The optimum extraction conditions were an extraction time of 71 min, an extraction temperature of 90°C in a solid-to-liquid ratio of 1:37 g/mL, and an ultrasonic power of 500 W. GFP was purified using DEAE-52 and Sephadex G-100. The structural characterization of GFP was performed using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ion chromatography (IC), and ultraviolet (UV) visible photometry. The morphology of GFP was analyzed by scanning electron microscopy (SEM), thermogravimetric differential scanning calorimetry (TG-DSC), and Congo red testing. In addition, the administration of GFP in oxazolone (OXZ)-induced ulcerative colitis (UC) in mice was found to prevent weight loss. Different doses of GFP (80, 160, and 320 mg/kg body weight) were used, and sulfapyridine (SASP) was used as a positive control (370 mg/kg body weight) for the treatment of OXZ-induced UC. After treatment, the mice were killed, and blood and colon tissue samples were collected. GFP was found to prevent decreases in colon length and the levels of leukocytes, platelets, and neutrophils in UC mice. Moreover, GFP also decreased the expression of pro-inflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-1 β], increased IL-10, and reduced colon injury in UC mice. The results showed that Under these conditions, the predicted polysaccharide yield was 21.72%, and the actual extraction rate was 21.13%. The polysaccharide composition (molar ratio) was composed of fucose (0.025), glucosamine hydrochloride (0.004), galactose (0.063), glucose (0.869), and mannose (0.038). GFP was also found to have a typical absorption peak, and the GFP extracted using the ultrasound-assisted extraction protocol was mainly β-glucan. These results indicate that ultrasound-assisted extraction of GFP could reduce OXZ-induced intestinal inflammation as a promising candidate for the treatment of UC, with the potential for development as a food supplement to improve intestinal diseases.

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Coumarin-rich Grifola frondosa ethanol extract alleviate lipid metabolism disorders and modulates intestinal flora compositions of high-fat diet rats

Cited by 16 publications

References 67 publications

Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices

Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices

Probiotics-Fermented Grifola frondosa Total Active Components: Better Antioxidation and Microflora Regulation for Alleviating Alcoholic Liver Damage in Mice

Structural properties and anti-inflammatory activity of purified polysaccharides from Hen-of-the-woods mushrooms (Grifola frondosa)

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