Coumarin functionalized dimeric mesogens for promising anticoagulant activity: Tuning of liquid crystalline property

A novel approach to construct a calix[4]arene-appended rhodamine B-based supramolecular system for nematic mesophase and nematode cell imaging

“…Within this mesophase, the molecules display long-range orientational order but do not possess long-range positional order. 55 The two side-substituted calixarene scaffolds exhibited a nematic phase, indicating the absence of any molecular arrangement characteristic of the smectic phase, such as a lamellar or layer-type structure. Moreover, the DSC analysis confirmed the presence of mesogenic properties in all four calixarene derivatives.…”

Anti-Alzheimer potential of coumarin derivatives: A review

“…Newly reported carbazole-coumarin hybrids (Fig. 6) evaluated their acetylcholinesterase inhibitor activity [15][16]. One carbazole-coumarin hybrid 17 a (R1=CH3, n=5) showed good acetylcholinesterase (AChE) inhibitory activity (IC50value of 6.72 µM) and another compound 17 b (n=4) that exhibits highly selective (over butyrylcholinesterase (BuChE) inhibitory activity (IC50= 0.50µM).These carbazole-coumarin hybrids found very promising Anti-Alzheimer activities as a selective and they have dual binding site inhibitor of AChE [38][39].…”

“…Coumarin is family of G-protein-coupled receptors (GPCRs) which is specially most important in treatment of neurological and psychiatric disorders like Parkinson's [9] and Alzheimer's disease [10], epilepsy [11], and schizophrenia [12]. Inflammatory [13], antithrombotic [14], anticancer [15], anticoagulant [16] activities, and cyclooxygenase [17], lipoxygenase [18], cholinesterase (ChE) and monoamine oxidase (MAO) inhibitor activity, CNS stimulant [19], vasodilator, and cytotoxic [20] effects. There are various derivatives of coumarins and chromenes, which were evaluated for their biological activities.…”