Coumarin derivatives as coronary vasodilators

Bariana, D. S.

doi:10.1021/jm00297a048

Cited by 14 publications

(3 citation statements)

References 1 publication

(3 reference statements)

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“…The anticoagulant activity of warfarin and its analogues has been known for decades [1]. Other coumarin derivatives have been found to act as vasodilators [2]. More recently, dihydrofurocoumarin analogues have been found to have several other beneficial physiological properties.…”

Section: Introductionmentioning

confidence: 99%

Enantioseparation of dihydrofurocoumarin derivatives by various separation modes of capillary electrophoresis

et al. 2003

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Chiral dihydrofurocoumarin compounds are currently the focus of industrial and pharmacological research. These derivatives have been shown to possess many physiological properties that could be medically beneficial. This work proposes four different chiral separation methods using capillary electrophoresis and micellar capillary electrophoresis (MCE). Several different cyclodextrin chiral selectors were examined to evaluate their effectiveness in the enantioseparation of dihydrofurocoumarins. In addition, the effects of the chiral selector concentration, the presence of an organic modifier, run buffer pH, and in two cases, the ratio between the chiral selector and an additional charged pseudophase were investigated. Overall, the best separations for this class of chiral compounds were achieved using sulfated beta-cyclodextrins at low pH in the reversed polarity mode.

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Section: Introductionmentioning

confidence: 99%

Enantioseparation of dihydrofurocoumarin derivatives by various separation modes of capillary electrophoresis

et al. 2003

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“…Hence this reaction used the coumarin skeleton 228, a natural product first isolated in 1830 from tonka beans. 108 Its derivatives exhibit broad biological activities, ranging from anti-inflammatory agents 109 and coronary vasodilators, 110 to tautomerase inhibitors 111 and selective FXIIa inhibitors. 112…”

Section: Scheme 30mentioning

confidence: 99%

Mannich–Michael versus formal aza-Diels–Alder approaches to piperidine derivatives

2011

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A review into the aza-Diels-Alder reaction, mainly concentrating on literature examples that form piperidin-4-ones from the reaction of imines and electron rich dienes or enones, either through a Lewis acidic/Brønsted acid approach or through the use of an organocatalyst. This review questions whether the mechanism of the aza-Diels-Alder reaction is step wise as opposed to concerted when using oxygenated dienes.

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“…On the other hand, coumarins have a wide spectrum of biological activities and uses [7][8][9][10][11][12][13][14]. Moreover, coumarins constitute an important class of organic fluorescent dyes.…”

Section: Introductionmentioning

confidence: 99%

ChemInform Abstract: Synthesis of Potentially Photoactivatable Coumarin Derivatives via a 1,3‐Dipolar Cycloaddition.

Chenot¹,

Rodríguez-Domínguez²,

Hannewald³

et al. 2009

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Coumarin derivatives as coronary vasodilators

Cited by 14 publications

References 1 publication

Enantioseparation of dihydrofurocoumarin derivatives by various separation modes of capillary electrophoresis

Enantioseparation of dihydrofurocoumarin derivatives by various separation modes of capillary electrophoresis

Mannich–Michael versus formal aza-Diels–Alder approaches to piperidine derivatives

ChemInform Abstract: Synthesis of Potentially Photoactivatable Coumarin Derivatives via a 1,3‐Dipolar Cycloaddition.

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