Coumarin-containing photo-responsive nanocomposites for NIR light-triggered controlled drug release via a two-photon process

Ji, Weidong; Li, Najun; Chen, Dongyun; Qi, Xiuxiu; Sha, Wenwei; Jiao, Yang; Xu, Qingfeng; Lu, Jianmei

doi:10.1039/c3tb21206h

Cited by 113 publications

(82 citation statements)

References 42 publications

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“…Two-photon absorption (2PA) is a typical nonlinear optical property that two photons are simultaneously absorbed to promote a molecule to the excited state by doubling the excitation energy. Introducing 2PA property to self-assembly system may find a variety of biomedical usages such as photodynamic therapy and drug delivery [36,81].…”

Section: Stimuli-responsive Emission Changementioning

confidence: 99%

Optical properties of amphiphilic copolymer-based self-assemblies

Wang

Lin

Cai

et al. 2015

European Polymer Journal

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Section: Stimuli-responsive Emission Changementioning

confidence: 99%

Optical properties of amphiphilic copolymer-based self-assemblies

Wang

Lin

Cai

et al. 2015

European Polymer Journal

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“…Upon absorption of 800 nm NIR light, a two-photon process triggered photocleavage of the photoactive chromophore resulting in a drastic change in the structure of the photoresponsive polymer NP through hydrophobic/hydrophilic switching, followed by photodegradation of the NP (Figure 2b). 48 …”

Section: Miscellaneous Phototriggered Drug Release Mechanismsmentioning

confidence: 99%

“…(b) Schematic indicating synthesis of a nanocarrier comprised of HMS@C18@HAMAFA- b -[7-(didodecylamino)coumarin-4-yl] methyl methacrylate and its application for delivery and controlled release of cargos using degradation upon NIR light exposure. Reprinted from ref 48; copyright 2013, The Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic therapy, photothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time monitoring and tracking combined with a therapeutic action to different diseases sites and organs). Combinations of these approaches can lead to enhanced and synergistic therapies, employing light as a trigger or for activation. Nonlinear light absorption mechanisms such as two-photon absorption and photon upconversion have been employed in the design of light-responsive DDSs. The integration of a light stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal controlled delivery and release of therapeutic agents, targeted and controlled nanosystems, combined delivery of two or more agents, their on-demand release under specific conditions, and so forth. Overall, light-activated nanomedicines and DDSs are expected to provide more effective therapies against serious diseases such as cancers, inflammation, infections, and cardiovascular disease with reduced side effects and will open new doors toward the treatment of patients worldwide.

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“…Controlled morphologies of heterogenous system have been achieved such as hollow, core–shell, and Janus structure MSMs, which are desirable for multifunctional applications combining optical sensing and biological medicine . For the hollow structure, the mesopores and inner cavity of hollow MSMs can serve as reservoirs for guest molecules to combine biosensing and cargo delivery . Core–shell nanostructures were also designed with mesoporous organosilica shells for ratio fluorescence sensing or photothermal therapy applications .…”

Section: Construction Of Architecturesmentioning

confidence: 99%

Interfacial Assembly of Mesoporous Silica‐Based Optical Heterostructures for Sensing Applications

Gao

Zeng

Liang

et al. 2020

Adv Funct Materials

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Functionalized mesoporous silica materials (MSMs) are extensively investigated in sensing science due to their diverse structural and optical properties including tunable pore size, modifiable surface properties, and excellent accessibility to active sites. In the last few years, great efforts have been devoted to developing modification methods for MSMs for sensing applications with augmented sensitivity, super selectivity, as well as targeting capability, and multimodal capabilities. The functional group, structure, morphology, and component levels in the assembly of heterostructures of MSMs are a key for high sensing performance. As the development of mesoporous silica‐based sensing materials progresses, diverse functional units and materials are rationally implemented into the mesoporous structures. These heterostructures can maintain the excellent structural features of mesoporous silica and the optical properties of the functional units simultaneously, which shows the advantages of photostability, design flexibility, and multifunctionality. Here, an up‐to‐date overview of the fabrication strategies, the properties, and the sensing mechanisms of optical heterostructures based on MSMs is provided. A number of crucial sensing domains, including ionic, molecules, temperature, and biological species are highlighted. Finally, the prospects and potential sensing applications of mesoporous silica‐based optical heterostructures are discussed.

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Coumarin-containing photo-responsive nanocomposites for NIR light-triggered controlled drug release via a two-photon process

Cited by 113 publications

References 42 publications

Optical properties of amphiphilic copolymer-based self-assemblies

Optical properties of amphiphilic copolymer-based self-assemblies

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Interfacial Assembly of Mesoporous Silica‐Based Optical Heterostructures for Sensing Applications

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