2017
DOI: 10.1038/srep45287
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Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications

Abstract: S009-131, a coumarin-chalcone hybrid, had been shown to possess anti-proliferative and anti-tumour effect by triggering apoptosis. In this report, we investigated role of DNA damage signalling pathway in S009-131 induced cancer cell death. Here we show that S009-131 causes DNA damage by potential binding to the minor groove which led to the phosphorylation and activation of ATM and DNA-PK, but not ATR, at earlier time points in order to initiate repair process. S009-131 induced DNA damage response triggered ac… Show more

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Cited by 25 publications
(17 citation statements)
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“…Absorption spectroscopy is one of the most useful and effective techniques in DNA-drug interaction studies. This technique allows recognizing the existence of interactions between DNA and molecules, as well as specifying the mode of interaction by utilizing the perturbations in the spectral observation 19,42,43 . Binding of different compounds to DNA may create a strong stacking interaction between the compounds and the base pairs of the DNA, and may cause the absorbance spectrum show some degrees of hypo-or hyperchromism 43 binding to the CT-DNA 34 .…”
Section: Absorption Spectroscopic Studies Of the Interaction Between mentioning
confidence: 99%
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“…Absorption spectroscopy is one of the most useful and effective techniques in DNA-drug interaction studies. This technique allows recognizing the existence of interactions between DNA and molecules, as well as specifying the mode of interaction by utilizing the perturbations in the spectral observation 19,42,43 . Binding of different compounds to DNA may create a strong stacking interaction between the compounds and the base pairs of the DNA, and may cause the absorbance spectrum show some degrees of hypo-or hyperchromism 43 binding to the CT-DNA 34 .…”
Section: Absorption Spectroscopic Studies Of the Interaction Between mentioning
confidence: 99%
“…Upon DNA damage, p53 elicit a multifaceted response in the cell and it decides various important cellular processes like DNA repair, cell cycle arrest and apoptosis, thereby maintaining the genomic integrity of the cells 18,19 . Unlike, other cellular transcription factors, p 53 is known to be mutated in almost all types of cancer.…”
Section: Introductionmentioning
confidence: 99%
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“…Immunofluorescence assay was performed as described previously 31 . The RAW264.7 was seeded in 6-well plates at a density of 2 × 10 5 cells/well.…”
Section: Immunofluorescence Assaymentioning
confidence: 99%
“…Coumarin is also named 2 H ‐chromen‐2‐one, which is a bicyclic oxygen‐containing heterocycle. It is reported that coumarin exists in numerous natural products , such as tanizin , anisucoumaramide , and defucogilvocarcin , and possesses good biological activities, for example, antitumor , anti‐ Escherichia coli , anticoagulation , and antifungal activities . Acenocoumarol is a noteworthy anticoagulant drug that functions as a vitamin K antagonist .…”
Section: Introductionmentioning
confidence: 99%