Coumamarin: a first coumarinyl calcium complex isolated from nature

Hamed, Abdelaaty; Frese, Marcel; Sproß, Jens; Stammler, Hans Georg; Sewald, Norbert; Shaaban, Mohamed

doi:10.1038/s41429-019-0207-7

Cited by 9 publications

(4 citation statements)

References 27 publications

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“…This effect could be attributed to a higher rate of ionization and Ca 2+ chelation by these agents, thereby increasing the solubility of CaOx crystals. [27] The comparison of the results obtained by the gravimetric technique with the study [16] shows that the aqueous extract of the leaves of Z. lotus has an ability to dissolve the CaOx stone with a percentage of : Ca +2 -Jujubogenin glycosid complex, this structure is inspired by Hamed et al [30] ; +2 exhibitor in calcium 7.65%. Saponins are the glycosides of triterpenes or steroids and include the group of cardiac glycosides and steroidal alkaloids [28] and the presence of hydroxyl groups in the saponins of the leaves of Zizyphus [2] allowed us to say that the presence of a part glycoside increases the complexing capacity of Ca +2 , so the inhibitory properties of crystal formation are high, [29] as shown in Figure 3.…”

Section: Discussionmentioning

confidence: 80%

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Ahmed¹

2020

IJGP

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Introduction: A large number of medicinal plants have been used in Algeria since antiquity, which claims the efficient cure of urinary stone, one of these plants is the specie Zizyphus lotus (Family: Rhamnaceae). Leaves of this species are traditionally used for the treatment of many diseases. Nowadays, numerous clinical studies have provided reliable results on the effects of several hundred plants on several diseases such as the problem of urinary stones. The objective of this study is evaluated in vitro the activity antilithiasic of the extract saponins created fraction. Materials and Methods: Inhibition and dissolution of calcium oxalate (CaOx) were studied by the use of the techniques turbidimetric and gravimetric, using a ultraviolet-visible spectrophotometer and a precision balance. Results and Discussion: Qualitative secondary metabolites determination in the leaves of Z. lotus showed the presence of polyphenols, saponins, flavonoids, alkaloids, and tannins, and the yield of the fraction rich in saponins is equal to 1.41%. The absorbance decreased with the increase in the concentration of extract indicating that decreased the nucleation of CaOx particles with inhibition at 55.23 ± 1.23%. The weight of CaOx crystal decreased with the increase in the concentration of saponins, and the extract at 100% concentration possesses a maximum percentage of dissolution equal to 91.95 ± 0.72%. This effect could be attributed to Ca 2+ chelation by the compounds that exist in this fraction. Conclusion: This study indicates that extract can be considered as feasible natural products to improve the efficiency of CaOx inhibition and dissolution.

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Section: Discussionmentioning

confidence: 80%

Untitled

Ahmed¹

2020

IJGP

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“…[71] The initial discovery of the naturally occurring calcium complex, coumamarin (59), occurred through the isolation process of the marine-derived Aspergillus sydowii ASTI, which was collected from Tiran Island in the Red Sea, Egypt. [72] Coumamarin (59) had activity against the tested bacteria and yeasts, whereas it displayed no cytotoxicity against the human cervix carcinoma cell line (KB-3-1).. [72] A new meroterpenoid with an α,β-unsaturated ester group, asperdemin (60), and two known compounds were isolated from the marine fungus Aspergillus versicolor. The modified Mosher's method was utilized to establish the absolute stereochemistry of 60.…”

Section: Metabolites From Marine-derived Aspergillus Speciesmentioning

confidence: 99%

“…On the other hand, compounds 55 and 56 showed moderate antibacterial efficacy against four pathogenic bacteria with MIC values of 32–64 μg/mL [71] . The initial discovery of the naturally occurring calcium complex, coumamarin ( 59 ), occurred through the isolation process of the marine‐derived Aspergillus sydowii ASTI, which was collected from Tiran Island in the Red Sea, Egypt [72] . Coumamarin ( 59 ) had activity against the tested bacteria and yeasts, whereas it displayed no cytotoxicity against the human cervix carcinoma cell line (KB‐3–1).…”

Section: Natural Sourcesmentioning

confidence: 99%

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Unravelling the Secrets of α‐Pyrones from Aspergillus Fungi: A Comprehensive Review of Their Natural Sources, Biosynthesis, and Biological Activities

Asmaey

2023

Chemistry & Biodiversity

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Aspergillus, one of the most product‐rich and genetically robust genera, contains a diverse range of species with potential economic and ecological implications. Chemically, Aspergillus is one of the essential sources of polyketides, alkaloids, diphenyl ethers, diketopiperazines, and other miscellaneous compounds, displaying a variety of pharmacological activities. The α‐pyrones are unsaturated six‐membered lactones. Although α‐pyrone has a small structure, it is responsible for the structural diversity of several natural and synthetic compounds and multiple biological activities. In this review, we have summarized approximately 178 α‐pyrone containing metabolites derivatives identified/reported from terrestrial, marine, endophytic, and filamentous Aspergillus species, including their sources, biological properties, and biosynthetic pathways until mid‐2023, for the first time. This review is the first to compile and analyze the available data on α‐pyrone metabolites from Aspergillus, which could facilitate further research and innovation in this field. Additionally, it offers a valuable source of scaffolds for future bioactive drug development, as some of these metabolites have shown potent antimicrobial, anti‐inflammatory, and anticancer effects. Therefore, this review has significant implications for the advancement of natural product chemistry, pharmacology, biotechnology, and medicine.

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