Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?

Chen, Feng; Qi, Wen; Jiang, Jun; Li, Hai Long; Tan, Yin Feng; Li, Yong Hui; Zeng, Nian Kai

doi:10.1016/j.jep.2015.12.031

Cited by 145 publications

(102 citation statements)

References 126 publications

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“…It should be noted that the majority of the ingredients in both Danggui and Honghua were hydrotropic, and the OB values of a third of the selected 31 active ingredients were less than 30%. Therefore, the availability of these active constituents by gut microbiota especially under the disease state may be a critical step towards the emergence of their bioactivities in vivo 75.…”

Section: Discussionmentioning

confidence: 99%

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Yue

Xin

Fan

et al. 2017

Sci Rep

115

121

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Herb pair Danggui-Honghua has been frequently used for treatment of blood stasis syndrome (BSS) in China, one of the most common clinical pathological syndromes in traditional Chinese medicine (TCM). However, its therapeutic mechanism has not been clearly elucidated. In the present study, a feasible system pharmacology model based on chemical, pharmacokinetic and pharmacological data was developed via network construction approach to clarify the mechanisms of this herb pair. Thirty-one active ingredients of Danggui-Honghua possessing favorable pharmacokinetic profiles and biological activities were selected, interacting with 42 BSS-related targets to provide potential synergistic therapeutic actions. Systematic analysis of the constructed networks revealed that these targets such as HMOX1, NOS2, NOS3, HIF1A and PTGS2 were mainly involved in TNF signaling pathway, HIF-1 signaling pathway, estrogen signaling pathway and neurotrophin signaling pathway. The contribution index of every active ingredient also indicated six compounds, including hydroxysafflor yellow A, safflor yellow A, safflor yellow B, Z-ligustilide, ferulic acid, and Z-butylidenephthalide, as the principal components of this herb pair. These results successfully explained the polypharmcological mechanisms underlying the efficiency of Danggui-Honghua for BSS treatment, and also probed into the potential novel therapeutic strategies for BSS in TCM.

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Section: Discussionmentioning

confidence: 99%

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Yue

Xin

Fan

et al. 2017

Sci Rep

115

121

View full text Add to dashboard Cite

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“…Medicinal plants selected from the so-called 'traditional herbal medicines' used historically by different medical cultures are now scientifically studied in the search for alternative products for the treatment of common infections. The existence of plant remedies with attributed 'antimicrobial' properties represents a huge chapter of herbal medicine in many places [17][18][19][20].…”

Section: The Equibioticsmentioning

confidence: 99%

Equibiotics: a new type of phyto-drug equilibrating local microbiota

Lozoya¹,

Gascn-Muro²,

Agero³

et al. 2018

Fighting Antimicrobial Resistance

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“…Metabolic pathways by the liver cytochrome P450 enzymes (CYP450) lead to the conversion of lipophilic compounds into more hydrophilic compounds, while the majority of biotransformations encoded for by the gut microbiome are reductive and hydrolytic reactions. In addition, the gut flora is responsible for demethylation, deacylation, decarboxylation, acetylation, dealkylation, dehalogenation, dehydroxylation, deamination, and oxidation/ dehydrogenation [1,[17][18][19][20]. Direct and indirect interactions can influence the activity and toxicity of xenobiotics [20].…”

Section: Introductionmentioning

confidence: 99%

“…Examples of indirect interferences are competition and/or inhibition of host enzymes by microbial metabolites, the alteration of host genes expression and reactivation of drugs by deconjugation of the phase II metabolite after enterohepatic circulation [11,21]. Varying health-promoting compounds present in the human diet such as polyphenols are characterized by a poor absorption in the small intestines, leading to extensive biotransformation of these xenobiotics by the gut microbiota [7,17].…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid as a Model Compound for Optimization of an In Vitro Gut Microbiome-Metabolism Model

Mortelé

Iturrospe

Lammens

et al. 2019

CA16112 - Luxemburg 2019

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It has been believed that the metabolism of xenobiotics occurred mainly by the cytochrome P450 enzyme system in the liver. However, recent data clearly suggest a significant role for the gut microbiota in the metabolism of xenobiotic compounds. This microbiotic biotransformation could lead to differences on activation, inactivation and possible toxicity of these compounds. In vitro models are generally used to study the colonic biotransformation as they allow easy dynamic and multiple sampling over time. However, to ensure this accurately mimics communities in vivo, the pre-analytical phase requires optimization. Chlorogenic acid, a polyphenolic compound abundantly present in the human diet, was used as a model compound to optimize a ready-to-use gut microbiome biotransformation platform. Samples of the in vitro gastrointestinal dialysis-model with colon stage were analyzed by liquid chromatography coupled to high resolution time-of-flight mass spectrometry. Complementary screening approaches were also employed to identify the biotransformation products.

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Could the gut microbiota reconcile the oral bioavailability conundrum of traditional herbs?

Cited by 145 publications

References 126 publications

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach

Equibiotics: a new type of phyto-drug equilibrating local microbiota

Chlorogenic Acid as a Model Compound for Optimization of an In Vitro Gut Microbiome-Metabolism Model

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