Could the endocrine disruptor bisphenol-A be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions

Emfietzoglou, Rodopi; Spyrou, Nikolaos; Mantzoros, Christos S.

doi:10.1016/j.metabol.2018.11.007

Cited by 28 publications

(15 citation statements)

References 87 publications

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“…315 Unfortunately, most of the commercially available resins are based on the nonrenewable diglycidyl ether of BPA (DGEBA), which was recently identified as an endocrine disrupting molecule associated with many disease entities, including cancer, cardiovascular disease, and reproductive and neurodevelopmental disorders. 316 The active search for new bioderived and nontoxic DGEBA alternatives for this reason has led to a series of studies on furan-based epoxy resins and curing agents. It should be noted that despite the renewable nature of furanic alcohols and acids, the corresponding epoxy monomers are only partially sustainable since epichlorohydrin is a non-renewable and highly toxic substance, the use of which should be avoided in the future.…”

Section: Branched Typementioning

confidence: 99%

Recent advances in the development of green furan ring-containing polymeric materials based on renewable plant biomass

Karlinskii

Ananikov

2023

Chem. Soc. Rev.

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Section: Branched Typementioning

confidence: 99%

Recent advances in the development of green furan ring-containing polymeric materials based on renewable plant biomass

Karlinskii

Ananikov

2023

Chem. Soc. Rev.

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“…The risk factors of head and neck squamous cell carcinoma (HNSCC) have not been elucidated until today. Main etiologic factors of HNSCC include human papilloma virus (HPV), tobacco, genetic predisposition, UV radiation, alcohol consumption, occupational exposure to wood and coal dust, asbestos, formaldehyde, and nutrition poor in vegetables and fruits [14,15].…”

Section: Mycobiome and Head And Neck Cancermentioning

confidence: 99%

Mycobiome and Cancer: What Is the Evidence?

Kounatidis

Christodoulatos

Panagopoulos

et al. 2021

Cancers

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Background: To date, most researchhas focused on the bacterial composition of the human microbiota. In this review, we synopsize recent data on the human mycobiome and cancer, highlighting specific cancer types based on current available evidence, presenting interesting perspectives and limitations of studies and laboratory methodologies. Recent findings: Head and neck cancer carcinoma (HNCC), colorectal carcinoma (CRC) and pancreatic ductal adenocarcinoma (PDA) have been associated with dissimilarities in the composition of mycobiota between cancer cases and non-cancer participants. Overall, fungal dysbiosis with decreased fungal richness and diversity was common in cancer patients; however, a specific mycobiotic signature in HNSCC or CRC has not emerged. Different strains of Candida albicans have been identified among cases with HNCC, whilst Lichtheimia corymbifera, a member of the Mucoraceae family, has been shown to predominate among patients with oral tongue cancer. Virulence factors of Candida spp. include the formation of biofilm and filamentation, and the secretion of toxins and metabolites. CRC patients present a dysregulated ratio of Basidiomycota/Ascomycota. Abundance of Malassezia has been linked to the occurrence and progression of CRC and PDA, particularly in animal models of PDA. Interestingly, Schizophyllum, a component of the oral mycobiome, may exhibit anti-cancer potential. Conclusion: The human mycobiome, per se, along with its interactions with the human bacteriome and the host, may be implicated in the promotion and progression of carcinogenesis. Fungi may be used as diagnostic and prognostic/predictive tools or treatment targets for cancer in the coming years. More large-scale, prospective, multicentric and longitudinal studies with an integrative multi-omics methodology are required to examine the precise contribution of the mycobiome in the etiopathogenesis of cancer, and to delineate whether changes that occur in the mycobiome are causal or consequent of cancer.

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“…Plasticizers have been associated with hormone-sensitive cancers such as breast, prostate, endometrial, ovarian, testicular and thyroid cancers, but also with non-hormonally sensitive cancers such as cervical and lung cancers, osteosarcoma, and meningioma [21].…”

Section: Introductionmentioning

confidence: 99%

Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review

Ferrante

Cristaldi

Conti

2021

JPM

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The daily environmental exposure of humans to plasticizers may adversely affect human health, representing a global issue. The altered expression of microRNAs (miRNAs) plays an important pathogenic role in exposure to plasticizers. This systematic review summarizes recent findings showing the modified expression of miRNAs in cancer due to exposure to plasticizers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, we performed a systematic review of the literature published in the past 10 years, focusing on the relationship between plasticizer exposure and the expression of miRNAs related to cancer. Starting with 535 records, 17 articles were included. The results support the hypothesis that exposure to plasticizers causes changes in or the deregulation of a number of oncogenic miRNAs and show that the interaction of plasticizers with several redundant miRNAs, such as let-7f, let-7g, miR-125b, miR-134, miR-146a, miR-22, miR-192, miR-222, miR-26a, miR-26b, miR-27b, miR-296, miR-324, miR-335, miR-122, miR-23b, miR-200, miR-29a, and miR-21, might induce deep alterations. These genotoxic and oncogenic responses can eventually lead to abnormal cell signaling pathways and metabolic changes that participate in many overlapping cellular processes, and the evaluation of miRNA-level changes can be a useful target for the toxicological assessment of environmental pollutants, including plastic additives and plasticizers.

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Could the endocrine disruptor bisphenol-A be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions

Cited by 28 publications

References 87 publications

Recent advances in the development of green furan ring-containing polymeric materials based on renewable plant biomass

Recent advances in the development of green furan ring-containing polymeric materials based on renewable plant biomass

Mycobiome and Cancer: What Is the Evidence?

Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review

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