Could Red Cell Distribution Width be a Marker in Hashimoto’s Thyroiditis?

Abstract

We suggest that elevated RDW values in patients without iron deficiency anemia may require further evaluation for HT, especially in female population.

Anemia in thyroid diseases

“…In a study by Bremner et al, 17 thyroxine concentrations negatively correlated with RDW. In addition, a similar association was observed by Aktas et al, 33 who analyzed hematological parameters in patients with Hashimoto thyroiditis (HT) in comparison with a healthy control group. They observed that patients with HT presented higher RDW values as compared with controls.…”

“…Moreover, it was proved to be a predictor of mortality in several conditions. 33 In a study by Dorgalaleh et al, 21 both hyperthyroidism and hypothyroidism were associated with significantly lower mean corpuscular volume (MCV), mean cell hemoglobin, mean corpuscular hemoglobin concentration, and hemoglobin and hematocrit levels, but higher RDW, as compared with euthyroid controls. In a study by Bremner et al, 17 thyroxine concentrations negatively correlated with RDW.…”

Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients

“…In addition, NLR and PLR are relatively stable as compared with individual white blood cells parameters, which are easily influenced by dehydration/overhydration, diluted blood specimens and blood specimen handling. In addition, not only NLR, PLR but also red cell distribution width have been assessed in autoimmune disease [3,18]. These might be useful in clinical practice.…”

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

“…The findings of the present study supported the above study and confirmed a possible and critical relationship between inflammation and RDW. Literature studies have shown that RDW increases in inflammatory bowel disease, Hashimoto's thyroiditis, thyroid cancer, dermatomyositis, and polymyositis, indicating that RDW reflects the inflammatory state of the human body. Although recent studies have clearly demonstrated that RDW is a reliable biomarker for cardiovascular morbidity and mortality, the underlying mechanism between inflammation and elevated RDW levels remains unclear.…”