Could neutrophil/lymphocyte ratio be an indicator of coronary artery disease, coronary artery ectasia and coronary slow flow?

Abstract

ObjectiveTo determine whether neutrophil/lymphocyte ratio (NLR) differed between patients with isolated coronary artery disease (CAD), isolated coronary artery ectasia (CAE), coronary slow flow and normal coronary anatomy.MethodsPatients who underwent coronary angiography were consecutively enrolled into one of four groups: CAD, coronary slow flow, CAE and normal coronary anatomy.ResultsThe CAD (n = 40), coronary slow flow (n = 40), and CAE (n = 40) groups had similar NLRs (2.51 ± 0.7, 2.40 ± 0.8, 2.6 ± 0.6, respectively) that were significantly higher than patients with normal coronary anatomy (n = 40; NLR, 1.73 ± 0.7). Receiver operating characteristics demonstrated that with NLR > 2.12, specificity in predicting isolated CAD was 85% and sensitivity was 75%, with NLR > 2.22 specificity in predicting isolated CAE was 86% and sensitivity was 75%. With NLR > 1.92, specificity in predicting coronary slow flow was 89% and sensitivity was 75%. Multivariate logistic regression analyses identified NLR as an independent predictor of isolated CAE (β = −0.499, 95% CI −0.502, −0.178; P < 0.001), CAD (β = −0.426, 95% CI −1.321, −0.408; P < 0.001), and coronary slow flow (β = −0.430, 95% CI −0.811, −0.240; P = 0.001 Table 2).ConclusionsNLR was higher in patients with CAD, coronary slow flow and CAE versus normal coronary anatomy. NLR may be an indicator of CAD, CAE and coronary slow flow.

Anti-inflammatory effects of rosuvastatin treatment in coronary artery ectasia patients in different age groups

“…The NLR may be an indicator of CAD, CAE and coronary slow ow. This nding suggests that a more severe in ammatory process could be involved in the development of CAE [26][27][28]. A more signi cant level of chronic in ammation might be linked with the pathogenesis of CAE, which is associated with not only in ammatory markers but also in ammatory cells in patients with CAE [29].…”

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

“…Among 17 studies of 8,988 subjects, 4 studies [ 14 , 16 , 20 , 23 ] reported ORs of high versus low NLR, 8 studies [ 10 – 12 , 17 , 19 , 21 , 22 , 26 ] reported mean differences of NLR between CAD and non-CAD patients, and 5 studies [ 13 , 15 , 18 , 24 , 25 ] reported both.…”

“…Thirteen studies reported mean difference in NLR between CAD and non-CAD patients (see Table 3 ). Most study designs (9/13 studies) were cross-sectional; three were case-control [ 11 , 17 , 22 ] and one [ 18 ] was cohort. USMD was 0.87 (95% CI: 0.52, 1.22).…”

Anti-inflammatory effects of rosuvastatin treatment on coronary artery ectasia patients of different age groups

“…The NLR may be an indicator of CAD, CAE, and coronary slow flow. This finding suggests that a more severe inflammatory process could be involved in CAE development [ 33 – 35 ]. In our study, we also studied the NLR between the NC and total CAE groups; the NLR was higher in the total CAE group than in the NC group, indicating the tendency of severe inflammation in CAE, although the result was not statistically significant ( P = 0.1025).…”