Could mucin 16 and colony-stimulating factor 2-receptor beta possible graft versus host disease biomarkers? Medical hypotheses

Souza, Milena Monteiro de; Paula, Fabiana Martins de; Hsieh, Ricardo; Macedo, Maria Cristina Martins de Almeida; Corral, Marcelo Andreetta; Nunes, Thaís Borguezan; Paula, Fernanda de; Lourenço, Sílvia Vanessa

doi:10.1016/j.mehy.2017.01.017

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…Differently expressed proteins in UWS of adults with mucosal GVHD compared with patients without GVHD or healthy controls included IL-1 receptor antagonist, cystatin-B, lactoperoxidase, and lactotransferrin (Table 2) [27,28]. Mucin 16 and colony-stimulating factor 2 receptor b were also differentially expressed between adults with cGVHD (oral symptoms not specified) and healthy controls ( Table 2) [44]. Moreover, 3 proteins S100A7, S100A8, and S100A9 short were differentially expressed between allogeneic patients with GVHD and those without GVHD and healthy individuals in a study including children age 14 years [45].…”

Section: Saliva Compositionmentioning

confidence: 99%

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Leeuwen

Potting

Huysmans

et al. 2019

Biology of Blood and Marrow Transplantation

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A B S T R A C T Severe oral problems, including oral mucositis (OM) and xerostomia, often occur after conditioning therapy for hematopoietic stem cell transplantation (HSCT). Saliva plays a major role in protecting the oral mucosa and teeth. Alterations in salivary flow rate or salivary components resulting in decreased salivary defence mechanisms may affect oral/mucosal health and may influence the severity of OM. A systematic review was conducted to assess the current scientific knowledge on changes in salivary function and composition before and after HSCT. All English or Dutch articles examining salivary flow rate or salivary components before and after HSCT were included after title/abstract selection by 2 independent reviewers (weighted k = .91). After quality assessment and exclusion of all research groups with both children age <14 years and adults, 33 articles were included for data analysis. Overall, the salivary flow rate was decreased at several days and months after HSCT. Although several salivary components were studied, most components were examined in only 1 or 2 studies with different patient populations or at different time points after HSCT. At 7 days after HSCT, albumin and proinflammatory cytokines were increased, whereas secretory IgA and components of the salivary antioxidant system were decreased. Secretory IgA levels were still reduced at 1 month after HSCT but returned to pre-HSCT values at 6 months after HSCT. Lactoferrin, secretory leukocyte protease inhibitor, and b 2 -microglobulin levels were increased at 6 months after HSCT. Our findings show that changes in saliva reflect an inflammatory response occurring immediately after HSCT, followed by evidence of increased salivary antimicrobial defense mechanisms by 6 months after HSCT.

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Section: Saliva Compositionmentioning

confidence: 99%

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Leeuwen

Potting

Huysmans

et al. 2019

Biology of Blood and Marrow Transplantation

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“…Consequently, it offers an alternative and accessible resource for biomarker discovery. To date, the few published proteomic studies screening saliva for oral cGVHD biomarkers have used pooled patient samples (Bassim et al, 2012;Chiusolo et al, 2013;Devic et al, 2014;Souza et al, 2017) with variable methods and outcomes.…”

Section: Introductionmentioning

confidence: 99%

Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease

et al. 2022

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Chronic graft-versus-host disease (cGVHD) targets include the oral mucosa and salivary glands after allogeneic hematopoietic stem cell transplant (HSCT). Without incisional biopsy, no diagnostic test exists to confirm oral cGVHD. Consequently, therapy is often withheld until severe manifestations develop. This proteomic study examined saliva and human salivary gland for a biomarker profile at first onset of oral cGVHD prior to initiation of topical steroid therapy. Whole saliva collected at onset of biopsy-proven oral GVHD was assessed using liquid chromatography-coupled tandem mass spectrometry with identification of 569 proteins, of which 77 significantly changed in abundance. ZG16B, a secretory lectin protein, was reduced 2-fold in oral cGVHD saliva (p <0.05), and significantly decreased in salivary gland secretory cells affected by cGVHD. Single-cell RNAseq analysis of healthy MSG localized ZG16B expression to two discrete acinar cell populations. Reduced ZG16B expression may indicate specific cGVHD activity and possibly general salivary gland dysfunction.

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“…We acknowledge that salivary gland damage might be due to the conditioning regimes, unspecific trauma, and a response of overall cGVHD, which is difficult to determine but it highlights the need for large cohort defined clinicopathological studies. Thus, it is crucial to identify early diagnostic criteria for sg-cGVHD and saliva biomarkers could potentially serve this purpose in the future [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Grading of minor salivary gland immuno-histopathology post-allogenic hematopoietic cell transplantation

Tollemar¹,

Arvidsson²,

Häbel³

et al. 2023

Heliyon

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Could mucin 16 and colony-stimulating factor 2-receptor beta possible graft versus host disease biomarkers? Medical hypotheses

Cited by 7 publications

References 17 publications

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease

Grading of minor salivary gland immuno-histopathology post-allogenic hematopoietic cell transplantation

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