Could molecular effects of Caulerpa racemosa metabolites modulate the impact on fish populations of Diplodus sargus?

Gorbi, Stefania; Giuliani, Maria; Pittura, Lucia; d’Errico, Giuseppe; Terlizzi, Antonio; Felline, Serena; Grauso, Laura; Mollo, Ernesto; Cutignano, Adele; Regoli, Francesco

doi:10.1016/j.marenvres.2014.01.010

Cited by 41 publications

(49 citation statements)

References 49 publications

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“…Recently, several studies on the growing problem of non-indigenous species have proven that the knowledge of marine bioactive compounds may indicate the capacity of non-indigenous species to invade new systems [1,2,3,4,5,6,7,8,9]. In a recent review, Mollo et al [10] showed that the commercial use of the natural products obtainable from marine bioinvaders might also be considered as an effective option for reducing their impact on marine ecosystems.…”

Section: Introductionmentioning

confidence: 99%

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

et al. 2016

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Recently, there is a growing interest towards the development of strategies for invasive seaweed control and exploitation as source of secondary metabolites. Here, we investigated the potential of exploitation in biotechnology and recycling options in eradication programs of the lipidic extract of the Mediterranean invasive seaweed Caulerpa cylindracea (Chlorophyta). The chemical characterization was carried out by means of multinuclear and multidimensional NMR spectroscopy. The fatty acid profile of C. cylindracea assessed the presence of several types of molecules known for antioxidant activity such as carotenoids, chlorophylls, pheophytins, and sterols. The NMR spectroscopy showed also the characteristic signals of saturated, unsaturated, and free fatty acids as well as other metabolites including the biopolymer polyhydroxybutyrate. The lipidic extract exerted an antioxidant activity corresponding to 552.14 ± 69.13 mmol Trolox equivalent/g (ORAC) and to 70.3 ± 2.67 mmol Trolox equivalent/g (TEAC). The extract showed an antibacterial activity against several Vibrio species, suggesting its potential use in the control of diseases in mariculture. Our results show that C. cylindracea, representing a critical hazard in coastal areas, could be transformed into a gain supporting specific management actions to reduce the effects of human pressures.

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Section: Introductionmentioning

confidence: 99%

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

et al. 2016

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“…the efficiency of its vegetative multiplication by cutting and propagules, the production of secondary metabolites) factors (Occhipinti- Ambrogi & al. 2011a, b;Gorbi & al. 2014).…”

Section: Discussionmentioning

confidence: 99%

An updated overview of invasive Caulerpa taxa in Sicily and circum- Sicilian Islands, strategic zones within the NW Mediterranean Sea

2017

Fl. Medit.

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“…The presence of caulerpin in fish tissues has been considered evidence of C. cylindracea consumption and then used as a marker of trophic exposure to the alien seaweed. Furthermore, the caulerpin levels have been correlated to some cellular and physiological alterations which included: (i) slight modulation of antioxidant defenses (glutathione reductase and glutathione levels); (ii) increased enzymatic activities of cytochrome P450, acetylcholinesterase and acyl CoA oxidase activities; (iii) changes of hepatosomatic and gonadosomatic indices [ 8 , 16 ]. However, the possible causal relationship between the different algal metabolites and the above observed alterations have not yet been fully clarified, and will require cross-disciplinary investigations ranging from natural product chemistry to chemical ecology, from pharmacology to eco-toxicology.…”

Section: Introductionmentioning

confidence: 99%

“…This approach led us to search for any correlation between changes in the metabolic profiles of D. sargus and its trophic exposure to C. racemosa evidenced by the accumulation of caulerpin in the fish tissues exposed to C. cylindracea . Therefore, caulerpin accumulation levels in fish liver, measured in our previous work focusing on biomarker analyses [ 8 , 16 ], have been here, instead, related to changes in the metabolic profiles of the plasma collected from the same fish sample using 1 H NMR spectroscopy and multivariate analysis both unsupervised (Principal Component Analysis, PCA) and supervised (Orthogonal Partial Least Square, PLS, and Orthogonal Partial Least Square Discriminant Analysis, OPLS-DA). Given that the plasma samples were collected in two periods, June and October 2012, along three areas of the Southern Apulian coast (SE, Italy), Brindisi (BR), Porto Cesareo (PC) and Torre Guaceto (TG), differently characterized in terms of C. cylindracea abundance, the metabolic profiles were also analyzed to evaluate possible variations related to the seasonal fluctuations of C. cylindracea.…”

Section: Introductionmentioning

confidence: 99%

1H NMR Spectroscopy and MVA Analysis of Diplodus sargus Eating the Exotic Pest Caulerpa cylindracea

et al. 2015

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The green alga Caulerpa cylindracea is a non-autochthonous and invasive species that is severely affecting the native communities in the Mediterranean Sea. Recent researches show that the native edible fish Diplodus sargus actively feeds on this alga and cellular and physiological alterations have been related to the novel alimentary habits. The complex effects of such a trophic exposure to the invasive pest are still poorly understood. Here we report on the metabolic profiles of plasma from D. sargus individuals exposed to C. cylindracea along the southern Italian coast, using 1H NMR spectroscopy and multivariate analysis (Principal Component Analysis, PCA, Orthogonal Partial Least Square, PLS, and Orthogonal Partial Least Square Discriminant Analysis, OPLS-DA). Fish were sampled in two seasonal periods from three different locations, each characterized by a different degree of algal abundance. The levels of the algal bisindole alkaloid caulerpin, which is accumulated in the fish tissues, was used as an indicator of the trophic exposure to the seaweed and related to the plasma metabolic profiles. The profiles appeared clearly influenced by the sampling period beside the content of caulerpin, while the analyses also supported a moderate alteration of lipid and choline metabolism related to the Caulerpa-based diet.

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Could molecular effects of Caulerpa racemosa metabolites modulate the impact on fish populations of Diplodus sargus?

Cited by 41 publications

References 49 publications

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

An updated overview of invasive Caulerpa taxa in Sicily and circum- Sicilian Islands, strategic zones within the NW Mediterranean Sea

1H NMR Spectroscopy and MVA Analysis of Diplodus sargus Eating the Exotic Pest Caulerpa cylindracea

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