Could Infection Effect Cognitive Function in Schizophrenia ? : One Egyptian Center Study

El-Hadidy, Mohamed Adel; Elemshaty, Wafaa; Othman, Walaa

doi:10.12816/0001365

Cited by 3 publications

(14 citation statements)

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“…Few studies have been done in the Arab countries that evaluate the cognitive impairment in patients with schizophrenia [ 23 – 25 ]. In Lebanon, some studies evaluated cognitive function in older people [ 26 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

Cross-cultural adaptation and validation of the Arabic version of the BACS scale (the brief assessment of cognition in schizophrenia) among chronic schizophrenic inpatients

et al. 2021

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Background Assessment of cognitive disorders in schizophrenia is becoming a part of clinical and research practice by using batteries that differ widely in their content. The Brief Assessment of Cognition in Schizophrenia (BACS) was developed to cover the main cognitive deficits of schizophrenia. The objective of this study was to assess concurrent validity of the Arabic version of the BACS with a standard neurocognitive battery of tests in Lebanese patients with schizophrenia and healthy controls. Methods A sample of 120 stable inpatients diagnosed with schizophrenia and 60 healthy controls received the Arabic version of the BACS in a first session, and a standard battery in a second session. Results Mean duration of completion for the BACS was 31.2 ± 5.4 min in patients with schizophrenia. All tests demonstrated significant differences between controls and patients (p < .01). Principal components analysis demonstrated that a one-factor solution best fits our dataset (64.8% of the variance). High Cronbach alpha was found (.85). The BACS composite scores were significantly correlated with the standard battery composite scores in patients (r = .73, p < .001) and healthy controls (r = .78, p < .001). Also, correlation analysis between the BACS sub-scores and the standard battery sub-scores showed significant results (p < .05). Conclusion Results showed that the Arabic version of the BACS demonstrated high ability to discriminate patients with schizophrenia from healthy controls and it is a useful tool for assessing cognition in patients with schizophrenia and could be used in clinical practice in Lebanon.

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Section: Introductionmentioning

confidence: 99%

Cross-cultural adaptation and validation of the Arabic version of the BACS scale (the brief assessment of cognition in schizophrenia) among chronic schizophrenic inpatients

et al. 2021

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“…The 13 studies 16,[27][28][29][30][31][32][41][42][43][44][45][46] included in the meta-analysis comprised 13 289 healthy participants (mean [SD] age, 46.7 [16.0] years based on 8 studies 29,31,32,[41][42][43][44]46 ies used the enzyme-linked immunosorbent assay to detect T gondii antibodies. Data eligible for meta-analysis comprised 4 cognitive domains: processing speed, working memory, short-term verbal memory, and executive functioning (eMethods 2 in the Supplement).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Additional Contributions: We thank Cynthia P. Wyman, MS, and Derin Cobia, PhD (Brigham Young University), Mohamed A. El-Hadidy, MD (Mansoura University [Egypt]), Patrick D. Gajewski, PhD (Leibniz Research Centre for Working Environment and Human Factors [Germany]), Wojciech Guenter, PhD (Nicolaus Copernicus University [Poland]), Vishwajit J. Nimgaonkar, MD, PhD (University of Pittsburgh School of Medicine), and Minna Torniainen-Holm, PhD (National Institute for Health and Welfare [Finland]). These authors shared their unpublished data or provided us with additional data on their published studies, [26][27][28][29][30][31][32] thereby contributing to a more reliable meta-analysis.…”

Section: Conflict Of Interest Disclosures: None Reportedmentioning

confidence: 99%

“…Data (summary estimates) were extracted from published articles, and 2 researchers (Lies H. and J.S.) requested additional (raw) data from the corresponding authors of selected studies [26][27][28][29][30][31][32] when the available published results were not usable for meta-analysis. Data provided were used in the meta-analysis with written permission from the authors of the following studies: Cobia et al 27 (D. Cobia, PhD, written communication, April 9, 2020), El-Hadidy et al 28…”

Section: Data Extractionmentioning

confidence: 99%

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Association of Toxoplasma gondii Seropositivity With Cognitive Function in Healthy People

et al. 2021

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IMPORTANCEThe parasite Toxoplasma gondii has been associated with behavioral alterations and psychiatric disorders. Studies investigating neurocognition in people with T gondii infection have reported varying results. To systematically analyze these findings, a meta-analysis evaluating cognitive function in healthy people with and without T gondii seropositivity is needed. OBJECTIVE To assess whether and to what extent T gondii seropositivity is associated with cognitive function in otherwise healthy people. DATA SOURCES A systematic search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. A systematic search of PubMed, MEDLINE, Web of Science, PsycInfo, and Embase was performed to identify studies from database inception to June 7, 2019, that analyzed cognitive function among healthy participants with available data on T gondii seropositivity. Search terms included toxoplasmosis, neurotoxoplasmosis, Toxoplasma gondii, cognition disorder, neuropsychological, and psychomotor performance.STUDY SELECTION Studies that performed cognitive assessment and analyzed T gondii seroprevalence among otherwise healthy participants were included.DATA EXTRACTION AND SYNTHESIS Two researchers independently extracted data from published articles; if needed, authors were contacted to provide additional data. Quantitative syntheses were performed in predefined cognitive domains when 4 independent data sets per domain were available. Study quality, heterogeneity, and publication bias were assessed. MAIN OUTCOMES AND MEASURES Performance on neuropsychological tests measuring cognitive function. RESULTSThe systematic search yielded 1954 records. After removal of 533 duplicates, an additional 1363 records were excluded based on a review of titles and abstracts. A total of 58 full-text articles were assessed for eligibility (including reference list screening); 45 articles were excluded because they lacked important data or did not meet study inclusion or reference list criteria. The remaining 13 studies comprising 13 289 healthy participants (mean [SD] age, 46.7 [16.0] years; 6586 men [49.6%]) with and without T gondii seropositivity were included in the meta-analysis. Participants without T gondii seropositivity had favorable functioning in 4 cognitive domains: processing speed (standardized mean difference [SMD], 0.12; 95% CI, 0.05-0.19; P = .001), working memory (SMD, 0.16; 95% CI, 0.06-0.26; P = .002), short-term verbal memory (SMD, 0.18; 95% CI, 0.09-0.27; P < .001), and executive functioning (SMD, 0.15; 95% CI, 0.01-0.28; P = .03). A meta-regression analysis found a significant association between older age and executive functioning (Q = 6.17; P = .01). Little suggestion of publication bias was detected.CONCLUSIONS AND RELEVANCE The study's findings suggested that T gondii seropositivity was associated with mild cognitive impairment in several cognitive domains. Although effect sizes were small, given the ubiquitous prevalence of this infection globally, th...

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“…Few studies have been done in the Arab countries that evaluate the cognitive impairment in patients with schizophrenia [19][20][21]. In Lebanon, some studies evaluated cognitive function in older people [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Cross-cultural Adaptation and Validation of the Lebanese Arabic version of the BACS scale (the Brief Assessment of Cognition in Schizophrenia) among stable schizophrenic inpatients

Haddad

Salameh

Hallit

et al. 2021

Preprint

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IntroductionAssessment of cognitive disorders in schizophrenia is becoming a part of clinical and research practice by using batteries that differ widely in their content. The Brief Assessment of Cognition in Schizophrenia (BACS) was developed to cover the main cognitive deficits of schizophrenia. The objective of this study was to assess concurrent validity of the Arabic version of the BACS with a standard neurocognitive battery of tests in Lebanese patients with schizophrenia and healthy controls.MethodsA sample of 120 stable inpatients diagnosed with schizophrenia and 60 healthy controls received the Arabic version of the BACS in a first session, and a standard battery in a second session. ResultsMean duration of completion for the BACS was 31.2 ± 5.4 min in patients with schizophrenia. All tests demonstrated significant differences between controls and patients (p < .01). Principal components analysis demonstrated that a one-factor solution best fits our dataset (64.8% of the variance). High Cronbach alpha was found (.85). The BACS composite scores were significantly correlated with the standard battery composite scores in patients (r = .78, p < .001) and healthy controls (r = .77, p < .001). Also, correlation analysis between the BACS sub-scores and the standard battery sub-scores showed significant results (p < .05). The Arabic-BACS demonstrated high ability to discriminate patients with schizophrenia from healthy controls.Conclusion Results showed that the Arabic version of the BACS is a useful tool for assessing cognition in patients with schizophrenia and could be used in clinical practice in Lebanon.

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Could Infection Effect Cognitive Function in Schizophrenia ? : One Egyptian Center Study

Cited by 3 publications

References 27 publications

Cross-cultural adaptation and validation of the Arabic version of the BACS scale (the brief assessment of cognition in schizophrenia) among chronic schizophrenic inpatients

Cross-cultural adaptation and validation of the Arabic version of the BACS scale (the brief assessment of cognition in schizophrenia) among chronic schizophrenic inpatients

Association of Toxoplasma gondii Seropositivity With Cognitive Function in Healthy People

Cross-cultural Adaptation and Validation of the Lebanese Arabic version of the BACS scale (the Brief Assessment of Cognition in Schizophrenia) among stable schizophrenic inpatients

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