Could IFN-γ predict the development of residual pleural thickening in tuberculous pleurisy?

Gerogianni, Irini; Papala, Maria; Tsopa, Paschalina; Zigoulis, Paris; Dimoulis, Andreas; Κostikas, Κonstantinos; Kiropoulos, Theodoros; Gourgoulianis, K.

doi:10.4081/monaldi.2008.407

Cited by 6 publications

(9 citation statements)

References 23 publications

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“…We have previously emphasized the benefits of this biomarker along with other biological parameters, confirming the diagnostic significance of ADA measurement in diagnosis and management of lymphocytic PEs in intermediate and high TB prevalence areas [2][3][4][5][6][7].…”

Section: To the Editormentioning

confidence: 76%

Necessity of co-operation between pulmonologists and internists in tuberculous pleurisy diagnosis

Zouridis

Kotsiou

Gerogianni

et al. 2019

Expert Review of Respiratory Medicine

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Section: To the Editormentioning

confidence: 76%

Necessity of co-operation between pulmonologists and internists in tuberculous pleurisy diagnosis

Zouridis

Kotsiou

Gerogianni

et al. 2019

Expert Review of Respiratory Medicine

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“…Other studies showed that high levels of IFN-γ, TGF-β and lower glucose in pleural effusion were correlated with the occurrence of pleural thickness in PT [29], and they thought that pleural thickness and loculation of pleural effusion were related to local pleural immune response associated with cytokines. Other researchers found pleural thickness was related to the imbalance of PAI-1 and t-PA in pleural effusion and PAI-1 increased, the t-PA decreased in PT patients with pleural thickness while decreased PAI-1, increased t-PA was found in patients with sufficient drainage of pleural effusions, therefore, PAI-1 and t-PA may be predictors of pleural thickness in PTM [9,18,27,29]. Our study had proved these changes of PAI-I and t-PA in PTM patients.…”

Section: Discussionmentioning

confidence: 89%

“…For cytokines tested in pleural effusion, their change of expression had been associated with immune response in patients with PT. With the development of immunological reaction in host, the immune factors in pleural effusion might be predictors of pleural thickness, packaged pleural effusion which could be quantitatively analyzed [23,27,28]. According to Chung [9], it was reported that the fibrinolytic activity was depressed in packaged pleural effusions compared with free-flowing effusions.…”

Section: Discussionmentioning

confidence: 99%

Predictive Risk Factors of Pleural Tuberculoma Occurrence on Patients with Pleural Tuberculosis

Dong¹,

Zhang²,

Wu³

et al. 2019

Preprint

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Background: Pleural tuberculoma (PTM) had been observed more and more frequently on patients with pleural tuberculosis (PT). The occurrence of PTM is not favorable for the treatment outcome of PT. However, its predictive risk factors had not been clarified. This study was to explore the predictive risk factors of PTM occurrence on the patients with PT. Methods: From January 2017 to June 2018, patients diagnosed as PT were enrolled prospectively into the study. All clinical characteristics and pleural changes during the chemotherapy were recorded and adenosine aminase (ADA)、 lactate dehydrogenase (LDH)、glucose and protein of pleural fluid were quantified. Interferon-gamma (IFN- γ)、 transforming growth factor -beta (TGF-β), plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) of pleural fluid were tested before chemotherapy by enzyme-linked immunosorbent assay (ELISA). Results: A total of 162 patients with PT were enrolled. 82 patients (51.3%, 82/162) developed PTM during chemotherapy. We found the probability of PT to develop PTM reached 99.5% when the patients with pleural thickness, packaged plural effusion, LDH>461.5 IU/L , ADA>62.9 IU/L , GLU<4.75 mmol/L and age>32.5 years old. The probability to develop PTM was as low as 1.4% when these 6 indices were in the opposite trend to the conditions list above. Using tested cytokines in pleural fluid from 76 cases, the probability of PTM if patients satisfied 3 indexes including increased TGF-β(>15.235 μ g/L) , increased PAI-1(>180.720 μ g/L) and decreased t-PA(<2.875 μ g/L ) was 78%, and the probability to develop PTM was only as low as 2.7% when these 3 cytokines were in the opposite trend. Conclusions: Age, pleural thickness, packaged pleural fluid, increased ADA, LDH, TGF-β, PAI-1 and decreased glucose and t-PA might be predictive risk factors of developing PTM for patients with PT, clinicians should take deep consideration if patients had above factors.

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“…However, the predictors affecting the development of RPT in patients with TBPE remain elusive. Previous studies reported that the concentrations of C-reactive protein, IL-1, IL-8, tumor necrosis factor- α , transforming growth factor- β 1, interferon- γ , and PAI-1 were significantly higher and the values of pH, glucose, and tPA were significantly lower in TBPE complicated with RPT than those without [ 6 , 26 – 30 ]. Moreover, pleural fluid loculation or fibrin septation detected by chest US as an initial presentation may be of value in predicting the development or occurrence of RPT in TBPE following completion of anti-TB medication [ 6 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion

Bien

Chen

et al. 2015

The Scientific World Journal

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Objective. To investigate the relationship among angiogenic cytokines, inflammatory markers, and fibrinolytic activity in tuberculous pleural effusion (TBPE) and their clinical importance. Methods. Forty-two patients diagnosed with TBPE were studied. Based on chest ultrasonography, there were 26 loculated and 16 nonloculated TBPE patients. The effusion size radiological scores and effusion vascular endothelial growth factor (VEGF), interleukin- (IL-) 8, plasminogen activator inhibitor type-1 (PAI-1), and tissue type plasminogen activator (tPA) were measured. Treatment outcome and pleural fibrosis, defined as radiological residual pleural thickening (RPT), were assessed at 6-month follow-up. Results. The effusion size and effusion lactate dehydrogenase (LDH), VEGF, IL-8, PAI-1, and PAI-1/tPA ratio were significantly higher, while effusion glucose, pH value, and tPA were significantly lower, in loculated than in nonloculated TBPE. VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE. Patients with higher VEGF or greater effusion size were prone to develop RPT (n = 14; VEGF, odds ratio 1.28, P = 0.01; effusion size, odds ratio 1.01, P = 0.02), and VEGF was an independent predictor of RPT in TBPE (receiver operating characteristic curve AUC = 0.985, P < 0.001). Conclusions. Effusion VEGF correlates with pleural inflammation and fibrosis and may be targeted for adjunct therapy for TBPE.

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Could IFN-γ predict the development of residual pleural thickening in tuberculous pleurisy?

Abstract: Pleural fluid IFN-gamma may deserve further investigation in order to build up preventive and therapeutic strategies against RPT and its clinical complications.

Cited by 6 publications

References 23 publications

Necessity of co-operation between pulmonologists and internists in tuberculous pleurisy diagnosis

Necessity of co-operation between pulmonologists and internists in tuberculous pleurisy diagnosis

Predictive Risk Factors of Pleural Tuberculoma Occurrence on Patients with Pleural Tuberculosis

VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion

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