Could ferritin level be an indicator of COVID‐19 disease mortality?

Abstract

Purpose While the number of COVID‐19 cases is increasing day by day, there is limited information known about the hematological and laboratory findings of the disease. We aimed to investigate whether serum ferritin level predicts mortality, is a marker for rapid progression for inpatients. Methods Our study included 56 patients who were died due to COVID‐19 as the study group, and 245 patients who were hospitalized and recovered as the control group. The laboratory data of the patients were evaluated from the first blood tests (pre) taken from the first moment of admittion to the hospital and the blood tests taken from before the patient's discharge or exitus (post) were evaluated retrospectively. Results The mean age of the nonsurvivor group was 62.0 ± 15.7 and the mean age of the control group was 54.34 ± 13.03. Age and length of stay are significantly higher in the nonsurvivor group. When comparing the pre and post values of ferritin, according to the two groups separately, there was no significant difference in the control group and a high level of significance was observed in the nonsurvivor group (p <0.01). Conclusion COVID‐19 disease caused by SARS‐CoV‐2 causes high mortality with widespread inflammation and cytokine storm. Ferritin is a cheap and widespread available marker, ferritin, which can be used for its predictivity of the mortality and hope it would be a usefull marker for clinicians for the management of the disease. This article is protected by copyright. All rights reserved.

Risk factors for severe and critically ill COVID‐19 patients: A review

“…Elevated levels of serum ferritin were associated with mortality and the development of severe outcomes in COVID‐19. Cytokine storm syndrome can cause multiorgan failure and hyperferritinemia 137,151,231,232 . A study including 141 patients with COVID‐19 reported that hyperferritinemia (Serum ferritin > 500 μg/L) was observed in all severe patients on admission, and the mild cases had a normal mean serum ferritin level of (303 ± 224 μg/ml); moreover, severe and ICU patients had higher ferritin levels than the mild patients (2.6 times and 5.8 times, respectively) 233 .…”

Potential biomarkers for the early prediction of SARS-COV-2 disease outcome

“…In this regard, several studies reported the elevation of ferritin in COVID-19 patients. A study suggested that the median level of ferritin was significantly (p < 0.01) higher in the non-survivor group than in the control (233.3 ng/ml vs 451.25 ng/ml) with a ROC cut-off value of 304.30 [ 51 ]. Similarly, a meta-analysis study reported that the pooled mean ferritin level was 673 ng/ml (p < 0.001) [ 52 ].…”

Evaluation the relationship of&nbsp;left ventricular global longitudinal strain and laboratory parameters in discharged patients with COVID-19: A follow-up study

“…Further studies with larger sample sizes are needed to con rm our results. Pro-BNP (pg/ml) -80,9 (7,1) 56,3 (12,1) 81 (19,9) 0,654 LDH (U/l) -281,7 ± 101,7 270,3 ± 97,3 431,3 ± 245,9 0,089…”

“…It increases in in ammation and contributes to the cytokine storm [18]. Prior studies found serum ferritin levels associated with disease severity and mortality in COVID-19 infection [19,20]. Besides, Wu et al found high serum ferritin levels associated with the development of ARDS in COVID-19 [21].…”