Could Ex Vivo Lung Perfusion Be a Platform to Decrease the Incidence of Chronic Lung Allograft Dysfunction?

Mohamed, Mohamed S.A.

doi:10.1016/j.arcmed.2015.03.004

Cited by 6 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cytokine production in response to the IRI may follow the following sequence of events: [5] • IRI → the activation of toll-like receptors (TLRs), the increased production of reactive oxygen species (ROS), and the inhibition of Na+/K+ ATPase and other K+ channels → the priming and activation of the graft inflammasomes → the increased production and release of IL1β and IL18, which increase the induction of IL6.…”

Section: Mini Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Shehata's solution for the ex vivo lung preservation; it sounds very good

Mohamed¹

2017

Cardiothorac Vasc Sci

View full text Add to dashboard Cite

The importance of lung transplantation is increasing, being the practical solution for the end stage pulmonary failure. Ex vivo graft preservation is an essential step in the transplantation surgery that consists of hypothermic preservation and normothermic perfusion.There are many preservation solutions that are used for the ex vivo lung preservation and are commercially available or institutionally used. Based on the clinical results, the effective preservation determines the clinical outcome of the transplantation surgery.Despite the great progress in the development of the preservation solutions, there is a continuous interest and need for further development, in order to achieve the perfectionism of the technique. This paper is an opinion article that theoretically introduces a new preservation solution, which has the potential to counteract the hazards facing the graft ex vivo and after transplantation, based on the most recently published data.

show abstract

Section: Mini Reviewmentioning

confidence: 99%

“…In addition, infliximab antagonizes TNFα. All together have the potential to significantly oppose and attenuate the IRI [5,6,15].…”

Section: Mini Reviewmentioning

confidence: 99%

Shehata's solution for the ex vivo lung preservation; it sounds very good

Mohamed¹

2017

Cardiothorac Vasc Sci

View full text Add to dashboard Cite

show abstract

“…The main injury during graft ischemia -reperfusion is mediated by the increased production of reactive oxygen species (ROS), the inhibition of the ATP-sensitive K + channels (both are involved in the activation of the graft inflammasomes, hence, the increased production of interleukins 1ß, 18 & 6), and the increased production of TNFα [11]. Glutathion and vitamin C provide potent antioxidant function, antagonizing ROS [12].…”

Section: The Innovation In This Solutionmentioning

confidence: 99%

“…Glutathion and vitamin C provide potent antioxidant function, antagonizing ROS [12]. Vitamin C and Pinacidil activate the ATPsensitive K + channels [11,13]. In addition, infliximab antagonizes TNFα [11].…”

Section: The Innovation In This Solutionmentioning

confidence: 99%

See 1 more Smart Citation

A cocktail solution for the ex vivo preservation and perfusion of the lung; Shehata solution

Mohamed¹

2016

Trends in Transplant

View full text Add to dashboard Cite

The importance of lung transplantation is increasing, being the practical solution for the end stage pulmonary failure. ex vivo graft preservation is an essential step in the transplantation surgery that consists of hypothermic preservation and or normothermic perfusion.There are many preservation solutions that are used for the ex vivo lung preservation and are commercially available or institutionally used. Based on the clinical results, the effective preservation determines the clinical outcome of the transplantation surgery.Despite the great progress in the development of the preservation solutions, there is a continuous interest at further development in order to achieve the perfectionism of the technique. This paper describes an innovative solution to be used for the hypothermic graft preservation and the ex vivo lung perfusion, trying to apply the advantages of the other solutions, while avoiding the disadvantages, based on the translational medical knowledge.Correspondence to: Mohamed S. A. Mohamed.

show abstract

Insulin Supplementation of the Lung Graft Cold Preservation Solution

Mohamed

2016

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

Could Ex Vivo Lung Perfusion Be a Platform to Decrease the Incidence of Chronic Lung Allograft Dysfunction?

Cited by 6 publications

References 20 publications

Shehata's solution for the ex vivo lung preservation; it sounds very good

Shehata's solution for the ex vivo lung preservation; it sounds very good

A cocktail solution for the ex vivo preservation and perfusion of the lung; Shehata solution

Insulin Supplementation of the Lung Graft Cold Preservation Solution

Contact Info

Product

Resources

About