Could be applied genetic markers to smoking cessation treatment?

Gaya, Patrícia Viviane; Scholz, Jaqueline; Santos, Juliana Rocha; Tomaz, Paulo Roberto Xavier; Abe, Tania Marie Ogawa; Jr., Miguel Nassif; Pereira, Alexandre C.; Santos, Paulo Caleb dos

doi:10.18332/tid/84277

Cited by 1 publication

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“…A recent study highlights the contribution of CHRNA4 (rs1044396 C> T) polymorphism in the choice of the best drug for anti-smoking treatment. According to this study, the effectiveness of varenicline is higher for patients with a CT or TT genotype than for those with CC 36 .…”

Section: Chrn Gene Polymorphismsmentioning

confidence: 65%

Genetic variability in the neurobiology of nicotine dependence: effects on smoking behavior

et al. 2023

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Background: Smoking dependence is a chronic disease and a public health problem. The neurobiology of nicotine addiction can explain smoking behavior. This system has genetic variability that has been associated with vulnerability to dependence. Genetic variability in the neurobiology of smoking can help to understand why individuals exposed to drugs may or may not become addicted. Objective: This study aims to address genetic variability in the neurobiology of smoking addiction with a focus on polymorphic genes related to the nicotinic response and the dopaminergic reward pathway. Method: This work involved a search of the main scientific research on genetic variability in the neurobiology of smoking and its effects on smoking behavior. One hundred and five studies were selected, most of which highlighted polymorphisms in the genes of nicotinic receptors, dopamine receptors, and nicotine metabolism. Results: The majority of studies have focused on genes related to the activation of the dopaminergic reward system by nicotine. Combinations between different polymorphisms were also highlighted, showing that interactions can determine a genetic profile of predisposition to smoking addiction. Additionally, gender and ethnicity were identified as relevant factors. Conclusion: Knowledge of the genetic bases involved in the individual response to smoking can enable a better understanding of inter-individual differences in smoking behavior, and contribute to improving the treatment of addiction.

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Section: Chrn Gene Polymorphismsmentioning

confidence: 65%