Could a high-fat diet rich in unsaturated fatty acids impair the cardiovascular system?

Medei, Emiliano; Lima-Leopoldo, Ana Paula; Pereira-Junior, Pedro Paulo; Leopoldo, André Soares; Campos, Dijon Henrique Salomé de; Raimundo, Juliana Montani; Sudo, Roberto T.; Zapata‐Sudo, Gisele; Bruder‐Nascimento, Thiago; Cordellini, Sandra; Nascimento, José; Cicogna, Antônio Carlos

doi:10.1016/s0828-282x(10)70469-4

Cited by 15 publications

(16 citation statements)

References 49 publications

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“…In accordance with our echocardiographic results, Lima- observed systolic function improvement in obese rats induced by unsaturated high-fat diet (UHFD) in the period of 30 weeks; authors suggest that the increase in FS and PWSV may be related to decreased after load and improved LV contractility; in addition, Oliveira Junior et al (2013) revealed, in obese rats by UHFD during 20 weeks, improved left ventricular systolic performance assessed by FS. In opposition, studies performed in obesity induced by SHFD (Okere et al 2006;Martins et al 2015) and UHFD (Carroll et al 2006;Okere et al 2006;Medei et al 2010), which vary from 8 to 20 weeks of treatment, showed no functional changes; however, other authors reported cardiac dysfunction in mice fed with UHFD for 20 weeks (Park et al 2005;Cao et al 2016), as well as Relling et al (2006), using obese rats in 12 weeks of treatment with high-fat diet. The papillary muscle results of current investigation showed that obesity did not cause dysfunction when it was evaluated at baseline condition and on stimulation by isoproterenol.…”

Section: Discussionmentioning

confidence: 94%

“…; Medei et al. ), which vary from 8 to 20 weeks of treatment, showed no functional changes; however, other authors reported cardiac dysfunction in mice fed with UHFD for 20 weeks (Park et al. ; Cao et al.…”

Section: Discussionmentioning

confidence: 98%

“…Although the association between excess adipose tissue and deleterious effect on the heart has been wide documented (Abel et al 2008;Aurigemma et al 2013;Zeng et al 2015), experimental studies with rodents have shown controversial results for the appearance of cardiac dysfunction in models of obesity induced by high-fat diets (Carroll et al 2006;Medei et al 2010), possibly by no standardization of an appropriate model.…”

Section: Introductionmentioning

confidence: 99%

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Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial β -adrenergic system and does not compromise cardiac function

et al. 2016

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Obesity is a worldwide pandemic associated with high incidence of cardiovascular disease. The mechanisms by which the obesity leads cardiac dysfunction are not fully elucidated and few studies have evaluated the relationship between obesity and proteins involved in myocardial β‐adrenergic (βA) system. The purpose of this study was to evaluate the cardiac function and βA pathway components in myocardium of obese rats. Male Wistar rats were distributed into two groups: control (n = 17; standard diet) and obese (n = 17; saturated high‐fat diet) fed for 33 weeks. Nutritional profile and comorbidities were assessed. Cardiac structure and function was evaluated by macroscopic postmortem, echocardiographic and isolated papillary muscle analyzes. Myocardial protein expression of β 1‐ and β 2‐adrenergic receptors, Gαs protein, adenylate cyclase (AC) and protein kinase A (PKA) was performed by Western blot. Cardiac cyclic adenosine monophosphate (cAMP) levels and PKA activity were assessed by ELISA. Obese rats showed increased adiposity index (P < 0.001) and several comorbidities as hypertension, glucose intolerance, insulin resistance, and dyslipidemia compared with control rats. Echocardiographic assessment revealed increased left atrium diameter (C: 4.98 ± 0.38 vs. Ob: 5.47 ± 0.53, P = 0.024) and posterior wall shortening velocity (C: 37.1 ± 3.6 vs. Ob: 41.8 ± 3.8, P = 0.007) in obese group. Papillary muscle evaluation indicated that baseline data and myocardial responsiveness to isoproterenol stimulation were similar between the groups. Protein expression of myocardial AC was higher in obese group than in the control (C: 1.00 ± 0.21 vs. Ob: 1.25 ± 0.10, P = 0.025), whereas the other components were unchanged. These results suggest that saturated high‐fat diet‐induced obesity was not effective in triggering cardiac dysfunction and impair the beta‐adrenergic signaling.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial β -adrenergic system and does not compromise cardiac function

et al. 2016

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“…All experiments and procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals, published by the U.S. National Institutes of Health 26 , and were approved by the Botucatu Medical School Ethics Committee (UNESP, Botucatu, SP, Brazil).…”

Section: Methodsmentioning

confidence: 99%

Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway

Campos

Leopoldo

Nascimento

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundObesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished.ObjectiveStudy the energy balance of the myocardium with the hypothesis that the increase in fatty acid oxidation and reduced glucose leads to cardiac dysfunction in obesity.Methods30-day-old male Wistar rats were fed standard and hypercaloric diet for 30 weeks. Cardiac function and morphology were assessed. In this paper was viewed the general characteristics and comorbities associated to obesity. The structure cardiac was determined by weights of the heart and left ventricle (LV). Myocardial function was evaluated by studying isolated papillary muscles from the LV, under the baseline condition and after inotropic and lusitropic maneuvers: myocardial stiffness; postrest contraction; increase in extracellular Ca2+ concentration; change in heart rate and inhibitor of glycolytic pathway.ResultsCompared with control group, the obese rats had increased body fat and co-morbities associated with obesity. Functional assessment after blocking iodoacetate shows no difference in the linear regression of DT, however, the RT showed a statistically significant difference in behavior between the control and the obese group, most notable being the slope in group C.ConclusionThe energy imbalance on obesity did not cause cardiac dysfunction. On the contrary, the prioritization of fatty acids utilization provides protection to cardiac muscle during the inhibition of glycolysis, suggesting that this pathway is fewer used by obese cardiac muscle.

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“…Recent studies have shown that high fat diets, with high levels of unsaturated [11-13] and/or saturated fatty acids [14-18], induce fat accumulation, metabolic disorders, and cardiac remodeling. Similarly, sugar intake, per se, has been associated with insulin resistance, hypertension, and cardiac effects in rats [19].…”

Section: Introductionmentioning

confidence: 99%

Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis

Oliveira

Padovani

Rodriguês

et al. 2013

Cardiovasc Diabetol

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BackgroundAlthough hypercaloric interventions are associated with nutritional, endocrine, metabolic, and cardiovascular disorders in obesity experiments, a rational distinction between the effects of excess adiposity and the individual roles of dietary macronutrients in relation to these disturbances has not previously been studied. This investigation analyzed the correlation between ingested macronutrients (including sucrose and saturated and unsaturated fatty acids) plus body adiposity and metabolic, hormonal, and cardiovascular effects in rats with diet-induced obesity.MethodsNormotensive Wistar-Kyoto rats were submitted to Control (CD; 3.2 Kcal/g) and Hypercaloric (HD; 4.6 Kcal/g) diets for 20 weeks followed by nutritional evaluation involving body weight and adiposity measurement. Metabolic and hormonal parameters included glycemia, insulin, insulin resistance, and leptin. Cardiovascular analysis included systolic blood pressure profile, echocardiography, morphometric study of myocardial morphology, and myosin heavy chain (MHC) protein expression. Canonical correlation analysis was used to evaluate the relationships between dietary macronutrients plus adiposity and metabolic, hormonal, and cardiovascular parameters.ResultsAlthough final group body weights did not differ, HD presented higher adiposity than CD. Diet induced hyperglycemia while insulin and leptin levels remained unchanged. In a cardiovascular context, systolic blood pressure increased with time only in HD. Additionally, in vivo echocardiography revealed cardiac hypertrophy and improved systolic performance in HD compared to CD; and while cardiomyocyte size was unchanged by diet, nuclear volume and collagen interstitial fraction both increased in HD. Also HD exhibited higher relative β-MHC content and β/α-MHC ratio than their Control counterparts. Importantly, body adiposity was weakly associated with cardiovascular effects, as saturated fatty acid intake was directly associated with most cardiac remodeling measurements while unsaturated lipid consumption was inversely correlated with these effects.ConclusionHypercaloric diet was associated with glycemic metabolism and systolic blood pressure disorders and cardiac remodeling. These effects directly and inversely correlated with saturated and unsaturated lipid consumption, respectively.

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Could a high-fat diet rich in unsaturated fatty acids impair the cardiovascular system?

Cited by 15 publications

References 49 publications

Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial β -adrenergic system and does not compromise cardiac function

Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial β -adrenergic system and does not compromise cardiac function

Obesity Preserves Myocardial Function During Blockade of the Glycolytic Pathway

Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis

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