Cough variant asthma patients are more depressed and anxious than classic asthma patients

Saito, Norihiro; Itoga, Masamichi; Tamaki, Mami; Yamamoto, Ayako; Kayaba, Hiroyuki

doi:10.1016/j.jpsychores.2015.03.011

Cited by 26 publications

(22 citation statements)

References 50 publications

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“…A 19-country study 42 conducted on 1,860 asthmatic adults found that emotional disorders, including bipolar, panic, generalized anxiety, specific phobia, posttraumatic stress, binge eating, and alcohol abuse, were associated with subsequent adult asthma onset. Saito et al 43 found that patients with cough-variant asthma were more depressed and anxious than patients with classic asthma.…”

Section: Discussionmentioning

confidence: 99%

The impact of anxiety and depression on outpatients with asthma

Ciprandi

Schiavetti

Rindone

et al. 2015

Annals of Allergy, Asthma & Immunology

148

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Section: Discussionmentioning

confidence: 99%

The impact of anxiety and depression on outpatients with asthma

Ciprandi

Schiavetti

Rindone

et al. 2015

Annals of Allergy, Asthma & Immunology

148

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“…Wen Li 1 Wei-jie Guan 2 Min Chen 3 Chen Qiu 4 Wei Tang 5 Xiansheng Liu 6 Xudong Xiang 7 Jing Li 8 Meiling Jin 9 Yuanrong Dai 10 Ping Chen 11…”

Section: A C K N O W L E D G M E N T Smentioning

confidence: 99%

“…Similarly, Kayaba et al demonstrated that patients with CVA were more depressed and anxious than the outpatients with CA. 9 It has been demonstrated that cough, shortness of breath, or chest discomfort such as chest pain or tightness could be the isolated symptom of asthma. 10,11 Our findings reaffirmed that patients with asthma can present with a variety of symptoms.…”

mentioning

confidence: 99%

Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study

Yan

Guan

et al. 2020

Clinical & Translational Med

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Dear editor, In 2013, we have reported chest tightness being the only respiratory symptom among 24 asthmatic patients on presentation, 1 and referred to this type of asthma as chest tightness variant asthma (CTVA). Compared with patients with classic asthma (CA) or cough variant asthma (CVA), 2,3 patients with CTVA also presented with eosinophilic airway inflammation. However, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. We therefore sought to explore the therapeutic response to standard asthma treatments among 76 patients with CTVA in a 52-week multicenter, prospective, real-world study. The study was conducted in 16 centers (see Supporting Information) in mainland China. Participants were recruited between April 1, 2015 and March 31, 2018 (Figure 1). We recruited treatment-naive patients (14-80 years of age) who had a history of chest tightness for at least 6 months. The definition of CTVA was made based on the chest tightness being the sole symptom and at least one of the following conditions was met: (a) an increase of >12% and >200 mL in forced expiratory volume in 1 s (FEV 1) after inhaling salbutamol; (b) airway hyperresponsiveness as evidenced by a positive finding of bronchial provocation test; (c) a weekly variability in diurnal peak expiratory flow (PEF) of greater than 10%; and (d) a marked clinical improvement in response to β2 receptor agonists, with or without inhaled corticosteroids (ICS). All patients were treated with ICS plus long-acting β2 receptor agonist based on the Global Initiative for Asthma (GINA) guidelines. The following baseline characteristics were collected from eligible patients: age, gender, the history of atopy, smoking status, body mass index (BMI), FEV 1 (percent predicted), the ratio of FEV 1 /forced vital capacity (FVC), diurnal variation in PEF, the fraction of exhaled nitric oxide (FeNO), patient-rated anxiety scale (SAS) This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…I approached with interest the article by Saito et al [1], in which the authors compared the presence of symptoms of depression and anxiety among patients with cough-variant asthma with those presenting the classic form of asthma. At the conclusion of my reading however, I was disappointed that the authors did not cite two published studies so relevant to the topic of their own.…”

mentioning

confidence: 99%

“…As the key discriminating factor between the classic and coughvariant forms of asthma is the presence of cough as the sole or predominant symptom in the latter [4], one must reasonably conclude that chronic cough is likely the major contributor to the findings of Saito and colleagues [1]. Thus, the aforementioned studies serve to support the findings of these authors and furthermore provide a very useful reminder of the devastating effects a refractory, chronic cough can have on an individual's quality of life.…”

mentioning

confidence: 99%

Letter to the Editor on Saito et al., “Cough variant asthma patients are more depressed and anxious than classic asthma patients.”

Dicpinigaitis

2015

Journal of Psychosomatic Research

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Cough variant asthma patients are more depressed and anxious than classic asthma patients

Cited by 26 publications

References 50 publications

The impact of anxiety and depression on outpatients with asthma

The impact of anxiety and depression on outpatients with asthma

Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study

Letter to the Editor on Saito et al., “Cough variant asthma patients are more depressed and anxious than classic asthma patients.”

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