Cough Triggers and Their Pathophysiology in Patients with Prolonged or Chronic Cough

Matsumoto, Hisako; Tabuena, Rollin P.; Niimi, Akio; Inoue, Hideki; Ito, Isao; Yamaguchi, Masafumi; Otsuka, Kojiro; Takeda, Takumi; Oguma, Tsuyoshi; Nakaji, Hitoshi; Tajiri, Tomoko; Iwata, Toshiyuki; Nagasaki, Tadao; Jinnai, Makiko; Matsuoka, Hiroaki; Mishima, Michiaki

doi:10.2332/allergolint.10-oa-0295

Cited by 47 publications

(35 citation statements)

References 31 publications

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“…Chronic cough can result from hypersensitivity to environmental factors, such as chemicals, scents, cold air, and smoke [125], but there are only two reports of an association between Asian dust and chronic cough symptoms. The preliminary study from Higashi et al [126] indicates that Asian dust triggers cough and allergic symptoms in adult patients suffering from chronic cough.…”

Section: Desert Dust and Other Respiratory Diseasesmentioning

confidence: 99%

A Systematic Review of Global Desert Dust and Associated Human Health Effects

et al. 2016

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Dust storms and sandy dust events originating in arid and semi-arid areas can transport particulate material, pollutants, and potential transport long distances from their sources. Exposure to desert dust particles is generally acknowledged to endanger human health. However, most studies have examined anthropogenic particulate sources, with few studies considering contributions from natural desert dust. A systematic literature review was undertaken using the ISI Web of Knowledge and PubMed databases with the objective of identifying all studies presenting results on the potential health impact from desert dust particles across the world. This review reveals an imbalance between the areas most exposed to dust and the areas most studied in terms of health effects. Among the human health effects of dust storms are mortality and morbidity, arising from respiratory system, circulatory system, and other diseases. We summarize the quantitative results of current scientific health research and possible pathological mechanisms, and describe some of the many challenges related to understanding health effects from exposures to desert dust particles. Overall, for respiratory and circulatory mortality, both positive and negative associations have been reported for PM 10 of desert dust, but only a positive relationship was reported between PM 2.5-10 and mortality, and a positive relationship was also reported between PM 2.5 and human mortality. Future pathological studies should continue to focus on those mechanisms causing the most harmful effect of desert dust on respiratory and cardiovascular diseases. More attention should also be paid to the association between desert dust and the morbidity of other diseases, such as those affecting the reproductive system and nervous system.

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Section: Desert Dust and Other Respiratory Diseasesmentioning

confidence: 99%

A Systematic Review of Global Desert Dust and Associated Human Health Effects

et al. 2016

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“…Exposure to environmental irritants, including ambient pollutants known to trigger cough both in children and adults, has been reviewed [8,9,10]. In addition, there is evidence from cross-sectional studies that have shown the association in adults [11,12]. Although longitudinal studies have also been performed in Europe and North America [13,14] with some inconsistent results, few have specifically studied ambient polycyclic aromatic hydrocarbons (PAH) among adults [15,16].…”

Section: Introductionmentioning

confidence: 99%

Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study

Anyenda

Higashi

Kambayashi

et al. 2016

IJERPH

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Information on potential cough triggers including environmental irritants is vital for successful management of chronic cough in patients. We investigated the relationship between ambient levels of particulate polycyclic aromatic hydrocarbons (PAH), nitrogen dioxide (NO2) and sulphur dioxide (SO2) exposures with cough prevalence. Eighty-three adult patients, who had been physician diagnosed with at least asthma, cough variant asthma and/or atopic cough, were divided into asthma and non-asthma groups. They recorded daily cough symptoms during 4 January–30 June 2011 study period while daily samples of total suspended particles were simultaneously collected by use of glass fiber filters and the particulate PAH content determined by high performance liquid chromatography coupled with a fluorescence detector. Ambient concentrations of NO2 and SO2 were obtained from a local monitoring site. Logistic regression models using generalized estimating equations were used to determine population-averaged estimates of association between cough prevalence and ambient pollutant exposures for the two groups. Fully adjusted odds ratios from single pollutant models were 1.083 (95% confidence interval (CI): 1.029, 1.140) and 1.097 (95% CI: 1.016, 1.185) per 0.57 ng/m3 for lag2 PAH exposure, while only for asthma group had significant associations with NO2 and SO2 exposures for both lag2 and lag02. Similar associations were observed in multipollutant models. This finding suggests that ambient PAH, NO2, and SO2 exposure even at low levels is related to cough prevalence in adult chronic cough patients and may be considered as aggravating factor during clinical management of the condition.

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“…7 A Japanese group evaluated the association of patient reported triggers with cough, including GERD induced symptoms. 8 Of 194 patients, only 19 had GERD as defined by questionnaire scores (Frequency Scale for Symptoms of GERD and QUEST – questionnaire for the diagnosis of reflux disease). These patients were more likely to report “spices” and “meals” as triggering cough and higher questionnaire scores were independently associated with cough symptoms.…”

Section: Approach To Diagnosis In Gastroenterologymentioning

confidence: 99%

Chronic cough

Gawron¹,

Kahrilas²,

Pandolfino³

2013

Current Opinion in Otolaryngology & Head and Neck Surgery

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Purpose of review The purpose of this review is to highlight recent work and provide recommendations on the approach for diagnosis and management of chronic cough in a gastroenterology clinic. Recent findings Chronic cough is a burdensome symptom affecting a large number of patients and contributes significant cost to the healthcare system. Recent work has shown that select patients may benefit from acid suppressive therapy and even surgery when there is true pathologic evidence of reflux disease with cough. However, judicious use and proper interpretation of diagnostic testing for gastroesophageal reflux in the setting of cough is important to avoid unnecessary or inappropriate therapy. Summary Chronic cough remains a vexing problem for many physicians, including gastroenterologists. It is important that physicians approach refractory cough in a multi-disciplinary manner. Future research is needed to better understand the likely central hypersensitivity response mediating reflux related cough and potential alternative approaches to therapy.

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Cough Triggers and Their Pathophysiology in Patients with Prolonged or Chronic Cough

Abstract: Several cough triggers may reflect the pathophysiology of prolonged or chronic cough.

Cited by 47 publications

References 31 publications

A Systematic Review of Global Desert Dust and Associated Human Health Effects

A Systematic Review of Global Desert Dust and Associated Human Health Effects

Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study

Chronic cough

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