Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors

Materazzi, Serena; Nassini, Romina; Gatti, Raffaele; Trevisani, Marcello; Geppetti, Pierangelo

doi:10.1007/978-3-540-79842-2_3

Cited by 30 publications

(23 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Environmental particles, such as cigarette smoke, wood smoke, or air pollution, also contain TRPA1 agonists (e.g., acrolein, crotonaldehyde), which cause reflex cough or bronchoconstriction (Grace and Belvisi, 2011). In contrast, substances such as menthol (TRPM8) are reported to inhibit cough and elicit bronchodilation (Materazzi et al, 2009). Much of what we know about TRP channels in the lung has been inferred from studies investigating the pain pathway.…”

Section: B the G Protein-coupled Receptor-transient Receptor Potentimentioning

confidence: 99%

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

Veldhuis¹,

Poole²,

Grace³

et al. 2014

Pharmacol Rev

136

135

View full text Add to dashboard Cite

Section: B the G Protein-coupled Receptor-transient Receptor Potentimentioning

confidence: 99%

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

Veldhuis¹,

Poole²,

Grace³

et al. 2014

Pharmacol Rev

136

135

View full text Add to dashboard Cite

“…subset of airway sensory nerves (Materazzi et al, 2009) and is commonly used to study cough in animals and humans and to assess cough reflex sensitivity in patients with airways diseases. The utility of this stimulus is that, when inhaled, capsaicin evokes both coughing and the associated urge to cough (Davenport et al, 2002;Mazzone et al, 2007).…”

Section: Supramedullary Activations After Capsaicin Challengementioning

confidence: 99%

Investigation of the Neural Control of Cough and Cough Suppression in Humans Using Functional Brain Imaging

et al. 2011

View full text Add to dashboard Cite

Excessive coughing is one of the most common reasons for seeking medical advice, yet the available therapies for treating cough disorders are inadequate. Humans can voluntarily cough, choose to suppress their cough, and are acutely aware of an irritation that is present in their airways. This indicates a significant level of behavioral and conscious control over the basic cough reflex pathway. However, very little is known about the neural basis for higher brain regulation of coughing. The aim of the present study was to use functional brain imaging in healthy humans to describe the supramedullary control of cough and cough suppression. Our data show that the brain circuitry activated during coughing in response to capsaicin-evoked airways irritation is not simply a function of voluntarily initiated coughing and the perception of airways irritation. Rather, activations in several brain regions, including the posterior insula and posterior cingulate cortex, define the unique attributes of an evoked cough. Furthermore, the active suppression of irritant-evoked coughing is also associated with a unique pattern of brain activity, including an involvement of the anterior insula, anterior mid-cingulate cortex, and inferior frontal gyrus. These data demonstrate for the first time that evoked cough is not solely a brainstem-mediated reflex response to irritation of the airways, but rather requires active facilitation by cortical regions, and is further regulated by distinct higher order inhibitory processes.

show abstract

“…TRPA1, a member of the TRP family of ion channels, is expressed in LVCF sensory terminals (4,37,38) and may be a major oxidant sensor in the lungs (4,52). TRPA1 can be activated by various chemical stimulants, including ROS (5,48).…”

Section: Discussionmentioning

confidence: 99%

Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1

Shen

Luo

Yang

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1. Am J Physiol Regul Integr Comp Physiol 303: R1175-R1185, 2012. First published October 17, 2012 doi:10.1152/ajpregu.00227.2012.-Obstructive sleep apnea, manifested by intermittent hypoxia and excess production of reactive oxygen species (ROS) in airways, is associated with hyperreactive airway diseases, but the mechanism remains unclear. Sensitization of lung vagal C fibers (LVCFs) contributes to the airway hypersensitivity. We investigated the mechanisms underlying the sensitization of LVCFs with acute intermittent hypoxia (AIH), by 10 episodes of exposure to 30 s of hypoxic air (0%, 5%, or 10% O 2) followed by 30 s of room air in anesthetized, open-chest, and artificially ventilated rats. Reflex apneic response to intravenous capsaicin (an LVCF stimulant), as measured by phrenic nerve activity, was concentration dependently augmented by AIH. Similarly, reflex apneic response to intravenous ␣,␤-methylene-ATP (another LVCF stimulant) was augmented by AIH (0% O 2). The reflex apnea evoked by these two stimulants was abolished by bilateral vagotomy, which suggests the involvement of lung vagal afferents. The AIH-augmented apneic response to these two stimulants was prevented by pretreatment with dimethylthiourea (a hydroxyl radical scavenger), N-acetyl-L-cysteine (an antioxidant) and HC-030031 [a transient receptor potential ankyrin 1 (TRPA1) receptor antagonist]. Consistently, electrophysiological study revealed the afferent responses of LVCFs to capsaicin or ␣,␤-methylene-ATP were augmented by AIH, and this sensitization of LVCFs was prevented by dimethylthiourea, N-acetyl-L-cysteine, and HC-030031. In contrast, AIH did not alter the afferent response of LVCFs to mechanical stimulation by lung hyperinflation. We concluded that AIH sensitizes LVCFs in rats, thus resulting in exaggerated airway reflexogenic responses to chemical stimulants, possibly by ROS action and activation of TRPA1 receptors. intermittent hypoxia; lung vagal C fibers; reactive oxygen species; transient receptor potential ankyrin 1 receptors OBSTRUCTIVE SLEEP APNEA (OSA), characterized by intermittent hypoxia during sleep, is associated with several hyperreactive airway diseases, including nocturnal asthma (6, 9), chronic nocturnal cough (10), and bronchial hyperreactivity (32). Patients with OSA generally show airway inflammation (47). Airway hypersensitivity is among the major mechanisms contributing to hyperreactive airways and is manifested by augmented sensory and reflexogenic responses to inhaled irritants or circulating mediators; the hypersensitivity is a prominent pathophysiological feature of airway inflammatory diseases (30, 31). The possible role of sensitization of airway afferents in the OSA-related hyperreactive airway diseases has not been explored.Lung vagal C fibers (LVCFs) are nociceptive-like free nerve endings that are sensitive to various chemicals or inhaled irritants, which leads to activation of various air...

show abstract

Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors

Cited by 30 publications

References 96 publications

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

The G Protein–Coupled Receptor–Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

Investigation of the Neural Control of Cough and Cough Suppression in Humans Using Functional Brain Imaging

Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1

Contact Info

Product

Resources

About