Cough induced by enalapril but not by captopril

Puolijoki, Hannu; Mm, Nieminen; Moilanen, E.; Siitonen, L; Lahdensuo, A; Reinikainen, Pekka; Vapaatalo, Heikki

doi:10.1183/09031936.93.02030289

Cited by 11 publications

(3 citation statements)

References 6 publications

(7 reference statements)

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“…LINDGREN [12] found that bronchial reactivity was within the nonnal range in patients with this side-effect, but that ACE inhibition caused a modest increase in bronchial reactivity. No change in bronchial reactivity on ACE inhibitors was seen in the patient reported in this issue of the Journal [31] and an earlier study found no ACE inhibitor-induced changes in bronchial reactivity in patients who coughed, even in the presence of pre-existing airflow obstruction [7]. Carefully controlled assessments of bronchial reactivity have not been done in sufficiently large numbers of patients to exclude a small effect or an effect present in only a small percentage of the population.…”

Section: Rapidly Adapting "Irritant" Receptors and Bronchial Reactivitymentioning

confidence: 98%

“…Carefully controlled assessments of bronchial reactivity have not been done in sufficiently large numbers of patients to exclude a small effect or an effect present in only a small percentage of the population. Bronchoconstriction itself can lead to cough, but several studies have shown no adverse effect of ACE inhibition on airflow, even in patients who cough [7,11,31].…”

Section: Rapidly Adapting "Irritant" Receptors and Bronchial Reactivitymentioning

confidence: 99%

“…The cough may become less troublesome particularly if the dose of ACE inhibitor is reduced, which may not necessarily lead to loss of therapeutic effect [32]. Some patients may cough less on an alternative ACE inhibitor [31], but whether this is due to a true difference in sensitivity or merely dosage differences is hard to say.…”

Section: Management Of Coughmentioning

confidence: 99%

See 2 more Smart Citations

Respiratory effects of angiotensin converting enzyme inhibition

Berkin¹

1989

Eur Respir J

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Section: Rapidly Adapting "Irritant" Receptors and Bronchial Reactivitymentioning

confidence: 98%

Section: Rapidly Adapting "Irritant" Receptors and Bronchial Reactivitymentioning

confidence: 99%

See 1 more Smart Citation

Respiratory effects of angiotensin converting enzyme inhibition

Berkin¹

1989

Eur Respir J

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Evaluation of ACE‐inhibitor (ACE‐I) associated cough using modified prescription sequence analysis (PSA)

Bowman

Carlstedt

Miller

et al. 1995

Pharmacoepidemiology and Drug

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Objective — Identify whether the prescription sequence of cough suppressant within one year following patients' first ACE‐I prescription can be used as an indicator for the occurrence of ACE‐I associated cough. Design — Observational retrospective controlled cohort design using all patients receiving ACE‐I as study cohort and patients having prescriptions for hydralazine, clonodine and prazosin as the control. Patient demographics and prescribing indications were controlled statistically using multivariate logistic regression. Setting — A large computerized clinical database encompassing the medical records of 450,000 patients seen over a 20‐year period at a county medical centre ambulatory clinic. Patients — 5373 patients exposed to any of captopril, enalapril, lisinopril, clonodine, hydralazine or prazosin. Main results — This study identified an odds ratio (OR) of 1.53 [95% confidence interal (CI) 1.17 to 2.01] for receipt of an antitussive following patients' first ACE‐I prescription. Other significant risk factors included female gender [OR = 1.52, CI 1.13 to 2.07] and diagnosis of congestive heart failure [OR = 1.47, CI 1.10 to 1.94]. Conclusion — The receipt of an antitussive following ACE‐I prescription may be used to monitor for ACE‐I associated cough, although its utility is unknown.

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Cough during Treatment with Angiotensin Converting Enzyme Inhibitors

et al. 1992

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SummaryThe role of age, gender, smoking habits and concomitant drug treatment, and type and dose of angiotensin converting enzyme (ACE) inhibitor as prognostic factors for the development of cough during ACE inhibition was investigated in a group of 1591 patients. In 117 of these patients cough was identified as drug related. Logistic regression confirmed that females, nonsmokers and patients treated with enalapril are at greater risk of developing cough. On the other hand, our data provided no evidence for a prognostic role of higher doses of the ACE inhibitor or of concomitant drug treatment; in particular, the use of tJ-adrenoceptor antagonists was not associated with a higher incidence of cough.A subset of patients treated with angiotensin converting enzyme (ACE) inhibitors develop a persistent cough, through a mechanism that is incompletely understood (Berkin 1989;Morice et al. 1989). The reported incidence of this adverse effect ranges from 0.2% (Chalmers et al. 1987;Edwards et al. 1987) to over 30% (Town et al. 1987). The true incidence of ACE inhibitor-related cough probably lies between these extremes and can be identified only by applying an appropriate methodology to collect patients' complaints and to verifY their relationship with drug treatment (Strocchi et al. 1989;Yeo & Ramsay 1990).Some evidence suggests that the occurrence of cough during treatment with ACE inhibitors is related to gender, type of inhibitor and smoking habits (Gibson 1989;Strocchi et al. 1989). The aim of this study was to investigate the incidence of cough and the prognostic value of these factors in a large population of unselected hypertensive patients treated with ACE inhibitors. Patients and MethodsA questionnaire on the use of antihypertensive drugs and the potential for subsequent development of adverse effects was sent to 2197 patients treated with ACE inhibitors during the preceding 5 years. 1591 patients (72.4%) correctly completed the questionnaire and were enrolled in this prospective nonconcurrent study (Lilienfeld 1976). Of the 214 cases of cough reported, 117 were judged to be drug related on the basis of direct patient interviews and the use of the operational identification algorithm proposed by Naranjo et al. (1981): 9 men and 37 women treated with captopril, 27 men and 32 women treated with enalapril, and 2 men and 10 women treated with both ACE inhibitors on separate occasions were identified. Further

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Cough induced by enalapril but not by captopril

Cited by 11 publications

References 6 publications

Respiratory effects of angiotensin converting enzyme inhibition

Respiratory effects of angiotensin converting enzyme inhibition

Evaluation of ACE‐inhibitor (ACE‐I) associated cough using modified prescription sequence analysis (PSA)

Cough during Treatment with Angiotensin Converting Enzyme Inhibitors

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